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Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells

  • Lee, Ye Eun (Department of Bioinformatics and Life Science, Soongsil University) ;
  • Kim, Soochan (Department of Bioinformatics and Life Science, Soongsil University) ;
  • Jung, Woong-Jae (Department of Bioinformatics and Life Science, Soongsil University) ;
  • Lee, Hyung Soo (Department of Bioinformatics and Life Science, Soongsil University) ;
  • Kim, Mi-Yeon (Department of Bioinformatics and Life Science, Soongsil University)
  • Received : 2014.09.17
  • Accepted : 2014.10.14
  • Published : 2014.10.31
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Abstract

ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, immunomodulatory effects of ZYM-201 on B cells were examined in vitro and in vivo. When splenocytes were activated with lipopolysaccharide (LPS), the major population which had shown an increase in cell numbers was B cells. However, when the B cells were treated with ZYM-201 after LPS activation, their cell numbers and the expression of major costimulatory molecules, CD80 and CD86, were decreased. Furthermore, the effect of LPS, which induces activation of NF-${\kappa}B$, was abolished by ZYM-201: LPS-stimulated B cells showed decrease of phosphorylation after treatment of ZYM-201. The same results were shown in vivo experiments. These results suggest that ZYM-201 may play a role in the modulation of inflammatory responses through inhibiting NF-${\kappa}B$ activation and downregulating the expression of costimulatory molecules on B cells.

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References

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