The Korean journal of internal medicine

  • 제29권4호
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  • Pages.482-488
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  • 2014
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Effects of pretransplant plasmapheresis and rituximab on recurrence of focal segmental glomerulosclerosis in adult renal transplant recipients

  • Park, Hoon Suk (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Hong, Yuah (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Sun, In O (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Chung, Byung Ha (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Hyung Wook (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Choi, Bum Soon (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Park, Cheol Whee (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Jin, Dong Chan (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Yong Soo (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Yang, Chul Woo (Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 투고 : 2013.07.09
  • 심사 : 2013.09.23
  • 발행 : 2014.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: Recurrent focal segmental glomerulosclerosis (FSGS) following renal transplantation is relatively common. However, the risk factors and optimal pretransplant treatment preventing recurrence of FSGS remain controversial. Methods: We retrospectively reviewed 27 adult renal transplant recipients with FSGS over a period of 10 years. We first compared possible risk factors for FSGS recurrence between the recurrence and nonrecurrence groups. Then we evaluated the effect of pretransplant plasmapheresis (PP; n = 4) and PP with rituximab (PP + RTX; n = 5) on recurrence of FSGS after transplantation compared to control patients that were not treated with these modalities. Results: There were seven recurrences in 27 patients (25.9%), but there were no significant differences in possible risk factors for FSGS recurrence between the two groups. Recurrence rates between patients with pretransplant PP or PP + RTX and control patients were not significantly different (22.2% vs. 27.7%, p > 0.05). There was also no significant difference in recurrence between the pretransplant PP and PP + RTX groups (25% vs. 20%, p > 0.05). Conclusions: Pretransplant PP or PP + RTX do not significantly decrease the recurrence of FSGS in adult renal transplant candidates.

키워드

참고문헌

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  8. Recurrent Focal Segmental Glomerulosclerosis After Kidney Transplantation in African Americans: Review of the Current Evidence vol.19, pp.12, 2014, https://doi.org/10.6002/ect.2020.0542
  9. Management of recurrent focal segmental glomerulosclerosis (FSGS) post renal transplantation vol.36, pp.1, 2014, https://doi.org/10.1016/j.trre.2021.100675
  10. Kidney Transplantation for Focal Segmental Glomerulosclerosis: Can We Prevent Its Recurrence? Personal Experience and Literature Review vol.11, pp.1, 2014, https://doi.org/10.3390/jcm11010093