DOI QR코드

DOI QR Code

Can we more efficiently save patients with vitamin K-dependent coagulopathy caused by superwarfarin intoxication?

  • Park, Jinny (Division of Hematology and Oncology, Department of Internal Medicine, Gachon University Gil Medical Center)
  • Received : 2014.06.13
  • Accepted : 2014.06.17
  • Published : 2014.07.01

Abstract

Keywords

References

  1. Hadler MR, Shadbolt RS. Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature 1975;253:275-277. https://doi.org/10.1038/253275a0
  2. Berry RG, Morrison JA, Watts JW, Anagnost JW, Gonzalez JJ. Surreptitious superwarfarin ingestion with brodifacoum. South Med J 2000;93:74-75. https://doi.org/10.1097/00007611-200093010-00017
  3. Watson WA, Litovitz TL, Klein-Schwartz W, et al. 2003 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 2004;22:335-404. https://doi.org/10.1016/j.ajem.2004.06.001
  4. Spahr JE, Maul JS, Rodgers GM. Superwarfarin poisoning: a report of two cases and review of the literature. Am J Hematol 2007;82:656-660. https://doi.org/10.1002/ajh.20784
  5. Waien SA, Hayes D Jr, Leonardo JM. Severe coagulopathy as a consequence of smoking crack cocaine laced with rodenticide. N Engl J Med 2001;345:700-701.
  6. Laposata M, Van Cott EM, Lev MH. Case records of the Massachusetts General Hospital: case 1-2007: a 40-yearold woman with epistaxis, hematemesis, and altered mental status. N Engl J Med 2007;356:174-182. https://doi.org/10.1056/NEJMcpc069032
  7. Bachmann KA, Sullivan TJ. Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin- sensitive rats. Pharmacology 1983;27:281-288. https://doi.org/10.1159/000137881
  8. Weitzel JN, Sadowski JA, Furie BC, et al. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases. Blood 1990;76:2555-2559.
  9. Lipton RA, Klass EM. Human ingestion of a 'superwarfarin' rodenticide resulting in a prolonged anticoagulant effect. JAMA 1984;252:3004-3005. https://doi.org/10.1001/jama.1984.03350210052030
  10. Misra D, Bednar M, Cromwell C, Marcus S, Aledort L. Manifestations of superwarfarin ingestion: a plea to increase awareness. Am J Hematol 2010;85:391-392.
  11. Pavlu J, Harrington DJ, Voong K, Savidge GF, Jan-Mohamed R, Kaczmarski R. Superwarfarin poisoning. Lancet 2005;365:628. https://doi.org/10.1016/S0140-6736(05)17916-1
  12. Sharma P, Bentley P. Of rats and men: superwarfarin toxicity. Lancet 2005;365:552-553. https://doi.org/10.1016/S0140-6736(05)17923-9
  13. Rost S, Fregin A, Ivaskevicius V, et al. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004;427:537-541. https://doi.org/10.1038/nature02214
  14. Hong J, Yhim HY, Bang SM, et al. Korean patients with superwarfarin intoxication and their outcome. J Korean Med Sci 2010;25:1754-1758. https://doi.org/10.3346/jkms.2010.25.12.1754
  15. Lee HJ, You MR, Moon WR, et al. Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum. Korean J Intern Med 2014;29:498-508. https://doi.org/10.3904/kjim.2014.29.4.498

Cited by

  1. Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period vol.95, pp.51, 2014, https://doi.org/10.1097/md.0000000000005461
  2. Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study vol.468, pp.None, 2014, https://doi.org/10.1016/j.jcis.2016.01.056