DOI QR코드

DOI QR Code

Development of Cardiovascular Simulator with Control of Pulse Pressure for Pulse Wave Study

맥압조절이 가능한 맥파 연구용 심혈관계 시뮬레이터 개발

  • 이주연 (상지대학교 동서의료공학과) ;
  • 김재욱 (한국한의학연구원) ;
  • 신상훈 (상지대학교 한방의료공학과)
  • Received : 2014.08.20
  • Accepted : 2014.09.30
  • Published : 2014.10.25

Abstract

The purpose of this study is to produce a simulator that can control a pulse pressure keeping the pulse wave transfer phenomenon. For this, the elastic tube is combined with a compliance chamber for the vessel part. The simulator is comprised of four parts; a pressure generation part with slider-crank mechanism, a vessel part with resistance controller, water reservoirs and a measurement part. The changes of waveform depending on the location of a chamber is examined to determine the position of a chamber. The effects of a chamber on the pulse pressure and the pulse wave transfer phenomenon were investigated. It showed that the simulator which had the chamber in upstream of tube produces pressure wave, being more similar to the clinical waveform than in downstream of tube. Furthermore, with the chamber, the simulator generates a pulse pressure, being more similar to the normal physiological values than without one. The chamber had little effect on the pulse wave velocity.

본 논문은 맥파전달현상을 유지하며 맥압을 조절할 수 있는 시뮬레이터를 제작하는 것이 목적이다. 이를 위해 탄성튜브와 컴플라이언스 챔버를 융합하였다. 본 시뮬레이터는 슬라이더-크랭크로 구성된 압력발생부, 저항조절부를 포함한 혈관부, 수조 그리고 측정부로 구성되어있다. 챔버의 위치선정을 위해 챔버의 위치에 따른 맥파의 변화를 실험하였다. 또한 챔버가 맥압에 미치는 영향을 보기 위해 챔버의 유무에 따른 맥압의 변화를 비교하였다. 챔버의 유무가 맥파전달현상에 미치는 영향을 조사하였다. 실험결과, 튜브의 상류지점에 챔버를 설치할 때가 하류지점에 설치할 때 보다 인체와 더 유사한 압력파형을 나타냈다. 챔버를 설치하였을 때가 설치하지 않았을 때보다 인체와 유사한 맥압을 생성하였다. 챔버의 설치여부에 따른 맥파 전달 속도는 큰 변화가 없었다.

Keywords

References

  1. D. Timms, M. Hayne, K. McNeil, and A. Galbraith, "A complete mock circulation loop for the evaluation of left-rightand biventricular assist devices," Artif Organs, vol. 29, no. 7, pp. 564-571, 2005. https://doi.org/10.1111/j.1525-1594.2005.29094.x
  2. S. Vandenberghe, F. Shu, D. K. Arnold and J. F. Antaki, "A simple, economical, and effective portable paediatric mock circulatory system," Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine., Vol. 225, no. 7, pp. 648-656, 2011. https://doi.org/10.1177/0954411911402287
  3. G. M. Pantalos, S. C. Koenig, K. J. Gillars, G. A. Giridharan and D. L. Ewert, "Characterization of an adult mock circulation for testing cardiac support devices," ASAIO J, vol. 50, no. 1, pp. 37-46, 2004. https://doi.org/10.1097/01.MAT.0000104818.70726.E6
  4. C. H. Kim, K. W. Lee, K. G. Nam and G. R. Jean, "Implementation of The Fluid Circulation Blood Pressure Simulator," Journal of Biomedical Engineering Research., Vol. 28, No. 6, pp.768-776, Dec 2007.
  5. S. H. Kim, W. K. Kim, B. C. Chang, and B. K. Cho, "In Vitro Test of a Monoleaflet Polymer Valve," IEIE Conference Vol. 15, No. 1, pp. 51-53, 1993.
  6. S. M. Kang, S. W. Choi "Optimal Control for Flow Rate Improvement in Conduit Shape Pulsatile Ventricular Assist Device," IEIE Summer Conference, Vol. 34, No. 1, pp. 1310-1313, 2011.
  7. J. Y. Lee, M. Jang and S. H. Shin, "Development of a Cardiovascular Simulator Focused on the Pressure Wave," Journal of Biomedical Engineering Research., Vol. 34, No. 1, pp. 40-45 2013. https://doi.org/10.9718/JBER.2013.34.1.40
  8. S. D. Gregory, M. Stevens, D. Timms and M. Pearcy, "Replication of the Frank-Starling response in a mock circulation loop," In Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, pp. 6825-6828, August 2011.
  9. H. A. Khalil, D. T. Kerr, M. A. Schusterman II, W. E. Cohn, O. H. Frazier and B. Radovancevic, "Induced pulsation of a continuous-flow total artificial heart in a mock circulatory system," The Journal of Heart and Lung Transplantation, Vol. 29, No. 5, pp. 568-573, 2010 https://doi.org/10.1016/j.healun.2009.12.004
  10. N. Westerhof, J. W. Lankhaar and B. E. Westerhof, "The arterial windkessel," Medical & biological engineering & computing, Vol. 47, No. 2, pp. 131-141, 2009. https://doi.org/10.1007/s11517-008-0359-2
  11. G. M. Pantalos, S. C. Koenig, K. J. Gillars, G. A. Giridharan and D. L. Ewert, "Characterization of an adult mock circulation for testing cardiac support devices," ASAIO journal, Vol. 50, No. 1, 37-46, 2004. https://doi.org/10.1097/01.MAT.0000104818.70726.E6
  12. Segers. P, Dubois. F, De Wachter. D and Verdonck. P, "Role and relevancy of a cardiovascular simulator," Cardiovascular Engineering, Vol. 3, No. 1, pp. 48-56, 1998.
  13. J. Y. Lee and S. H. Shin, "Development of the Cardiovascular Simulator for Pulse Diagnosis Study," The Journal Of The Korea Institute Of Oriental Medical Diagnostics, vol. 16, no. 1, pp. 19-26, 2012.
  14. N. Westerhof, N. Stergiopulos and M. I. Noble, Snapshots of hemodynamics: an aid for clinical research and graduate education, Springer, pp. 22, 2010
  15. R. J. Rodeheffer, G. Gerstenblith, L.C. Becker, J.L. Fleg, M.L. and Weisfeldt, "Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate," Circulation, Vol. 69, No. 2, pp. 203-213, 1984. https://doi.org/10.1161/01.CIR.69.2.203
  16. A. P. Avolio. "Multi-branched model of the human arterial system," Medical and Biological Engineering and Computing, Vol. 18, No. 6, pp. 709-718, 1980. https://doi.org/10.1007/BF02441895
  17. D. J. Patel, J. S. Janicki, and T. E. Carew, "Static anisotropic elastic properties of the aorta in living dogs," Circulation Research, Vol. 25, pp. 765-779. 1969. https://doi.org/10.1161/01.RES.25.6.765
  18. A. C. Pearson, R. Guo, D. A. Orsinelli, PF. Binkley and TJ. Pasierski, "Transesophageal echocardiographic assessment of the effects of age, gender, and hypertension on thoracic aortic wall size, thickness, and stiffness," American Heart Journal, Vol. 128, pp. 344-351, 1994. https://doi.org/10.1016/0002-8703(94)90488-X
  19. B. M. Pannier, A. P. Avolio, A. Hoeks, G. Mancia and K. Takazawa, "Methods and devices for measuring arterial compliance in humans," American journal of hypertension, Vol. 15, No. 8, pp. 743-753, 2002. https://doi.org/10.1016/S0895-7061(02)02962-X
  20. M. F. O'Rourke, R. P. Kelly, A. P. Avolio, The arterial pulse, Lea & Febiger, 1992, pp. 57.
  21. M. Zamir, The physics of pulsatile flow, Springer, 2000, pp. 163.