Journal of The Korean Dental Society of Anesthesiology (대한치과마취과학회지)

The Korean Dental Society of Anesthsiology (대한치과마취과학회)
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Effect of Age on Optimal Clinical Dose of Dexmedetomidine Sedation

덱스메데토미딘의 임상 용량의 나이에 따른 변화

  • Choi, Yoon Ji (Department of Dental Anesthesiology, Seoul National University Dental Hospital) ;
  • Baik, Jae Won (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ro, Young Jin (Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 최윤지 (서울대학교 치과병원 치과마취과) ;
  • 백재원 (서울아산병원 마취통증의학과) ;
  • 노영진 (서울아산병원 마취통증의학과)
  • Received : 2014.08.19
  • Accepted : 2014.10.02
  • Published : 2014.09.30
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Abstract

Background: Dexmedetomidine is known to be administered for sedation safely even in a very elderly patient. The purpose of this study was to determine the effect of age on clinically optimal dose of dexmedetomidine for sedation. Methods: We enrolled 50 patients ASA class I and II, scheduled for lower extremity surgery that need. They were classified into a young group (n = 26), aged below 75 and an old group (n = 24), aged above 75. Dexmedetomidine was continuously infused $0.5{\mu}g/kg$ within 10 min, followed by maintenance at a dose of $0.5{\mu}g/kg/min$, initially. The next dose was selected using the Dixon's up-and-down method. Results: The cED50 of dexmedetomidine required to maintain optimal sedation level in young and old group were 0.50 and $0.48{\mu}g/kg$, respectively. With isotonic regression, cED95 of dexmedetomidine was $0.71{\mu}g/kg$ (95% confidence intervals $0.57-1.06{\mu}g/kg$) and $0.58{\mu}g/kg$ (95% confidence intervals $0.51-0.67{\mu}g/kg$). There were no significant differences in cED50 (P = 0.21), recovery variables, or incidence of side effects between the two groups. Conclusions: Clinically optimal dose of dexmedetomidine was not affected to the age during sedation.

Keywords

References

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