DOI QR코드

DOI QR Code

In vitro cytotoxic activity of ginseng leaf/stem extracts obtained by subcritical water extraction

  • Lee, Kyoung Ah (Department of Food Science and Biotechnology of Animal Resources, Konkuk University) ;
  • Kim, Kee-Tae (Bio/Molecular Informatics Center, Konkuk University) ;
  • Chang, Pahn-Shik (Department of Agricultural Biotechnology, Seoul National University) ;
  • Paik, Hyun-Dong (Department of Food Science and Biotechnology of Animal Resources, Konkuk University)
  • Received : 2013.11.29
  • Accepted : 2014.05.22
  • Published : 2014.10.15

Abstract

Ginseng leaf/stem extract produced by subcritical water extraction at high temperature ($190^{\circ}C$) posses higher cytotoxic activity against human cancer cell lines than ethanol extract. Subcritical water extraction can be a great candidate for extraction of functional substance from ginseng leaves/stems.

Keywords

References

  1. Lee HJ, Lee H-S, Cho HJ, Kim SY, Suh HJ. Utilization of hydrolytic enzymes for the extraction of ginsenosides from Korean ginseng leaves. Process Biochem 2012;47:538-43. https://doi.org/10.1016/j.procbio.2011.12.004
  2. Jung CH, Seog H-M, Choi I-W, Cho HY. Antioxidant activities of cultivated and wild Korean ginseng leaves. Food Chem 2005;92:535-40. https://doi.org/10.1016/j.foodchem.2004.08.021
  3. Sun Y. Structure and biological activities of the polysaccharides from the leaves, roots and fruits of Panax ginseng C.A. Meyer: an overview. Carbohydr Polym 2011;85:490-9. https://doi.org/10.1016/j.carbpol.2011.03.033
  4. Wu J, Zhong J-J. Production of ginseng and its bioactive components in plant cell culture: current technological and applied aspects. J Biotechnol 1999;68:89-99. https://doi.org/10.1016/S0168-1656(98)00195-3
  5. Jung C-H, Seog H-M, Choi I-W, Park M-W, Cho H-Y. Antioxidant properties of various solvent extracts from wild ginseng leaves. LWT Food Sci Tehnol 2006;39:266-74. https://doi.org/10.1016/j.lwt.2005.01.004
  6. Galkin AA, Lunin VV. Subcritical and supercritical water: a universal medium for chemical reactions. Russ Chem Rev 2005;74:21-35. https://doi.org/10.1070/RC2005v074n01ABEH001167
  7. Pourali O, Asgharib FS, Yoshida H. Production of phenolic compounds from rice bran biomass under subcritical water conditions. Chem Eng J 2010;160:259-66. https://doi.org/10.1016/j.cej.2010.02.057
  8. Aliakbarian B, Fathi A, Perego P, Dehghani F. Extraction of antioxidants from winery wastes using subcritical water. J Supercrit Fluids 2012;65:18-24. https://doi.org/10.1016/j.supflu.2012.02.022
  9. Hassas-Roudsari M, Chang PR, Pegg RB, Tyler RT. Antioxidant capacity of bioactives extracted from canola meal by subcritical water, ethanolic and hot water extraction. Food Chem 2009;114:717-26. https://doi.org/10.1016/j.foodchem.2008.09.097
  10. Wang X, Wei Y, Yuan S, Liu G, Zhang YLJ, Wang W. Potential anticancer activity of litchi fruit pericarp extract against hepatocellular carcinoma in vitro and in vivo. Cancer Lett 2006;239:144-50. https://doi.org/10.1016/j.canlet.2005.08.011
  11. Nuutila AM, Kammiovirta K, Oksman-Caldentey KM. Comparison of methods for the hydrolysis of flavonoids and phenolic acids from onion and spinach for HPLC analysis. Food Chem 2002;76:519-25. https://doi.org/10.1016/S0308-8146(01)00305-3
  12. Bae HJ, Jayapraksha GK, Jifon J, Patil BS. Extraction efficiency and validation of an HPLC method for flavonoid analysis. Food Chem 2012;130:751-8. https://doi.org/10.1016/j.foodchem.2011.07.041
  13. Li B, Wang C-Z, He T-C, Yuan C-S, Wei D. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett 2010;289:62-70. https://doi.org/10.1016/j.canlet.2009.08.002

Cited by

  1. Dissipation, residues, and safety evaluation of trifloxystrobin and tebuconazole on ginseng and soil vol.187, pp.6, 2015, https://doi.org/10.1007/s10661-015-4591-6
  2. Comparative analysis of the antioxidant and anticancer activities of chestnut inner shell extracts prepared with various solvents vol.96, pp.6, 2014, https://doi.org/10.1002/jsfa.7324
  3. Subcritical Water Extraction of Biological Materials vol.46, pp.1, 2017, https://doi.org/10.1080/15422119.2016.1170035
  4. Subcritical water extraction of bioactive components from ginseng roots (Panax ginseng C.A. Mey) vol.117, pp.None, 2014, https://doi.org/10.1016/j.indcrop.2018.02.079
  5. Compuestos fenólicos y actividad antioxidante de los extractos de la hoja de chirimoya (Annona cherimola Mill) vol.48, pp.2, 2019, https://doi.org/10.15446/rev.colomb.quim.v48n2.76029
  6. The content of triterpene saponins and phenolic compounds in American ginseng hairy root extracts and their antioxidant and cytotoxic properties vol.138, pp.2, 2019, https://doi.org/10.1007/s11240-019-01633-3
  7. A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng vol.68, pp.6, 2014, https://doi.org/10.1007/s00005-020-00597-z
  8. Saponins derived from the stems and leaves of Panax ginseng attenuate scrotal heat‐induced spermatogenic damage via inhibiting the MAPK mediated oxidative stress and apoptosis in mice vol.35, pp.1, 2021, https://doi.org/10.1002/ptr.6801