Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
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Ameliorating Effect of Selenium against Arsenic Induced Male Reproductive Toxicity in Rats

  • Jalaludeen, Abdulkadhar Mohamed (Department of Animal Science, College of Natural Science, Konkuk University) ;
  • Lee, Ran (Department of Animal Science, College of Natural Science, Konkuk University) ;
  • Lee, Won Young (Department of Animal Science, College of Natural Science, Konkuk University) ;
  • Kim, Dong Hoon (Animal Biotechnology Division, National Institute of Animal Science, RDA) ;
  • Song, Hyuk (Department of Animal Science, College of Natural Science, Konkuk University)
  • Received : 2014.09.01
  • Accepted : 2014.09.16
  • Published : 2014.09.30
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Abstract

Oral exposure of humans by excess amounts of arsenic may cause disturbances of the reproductive system. In the present study, such exposure was modelled in rats, with the support of sperm principal parameters and histopathological observations. Male Sprague-Dawley rats were randomly divided into three groups where the group I was served as a normal control, group II was received sodium meta-arsenite as arsenic (10 mg/kg b.w/day) and a combination of sodium meta-arsenite and sodium selenite (3 mg/kg b.w/day) in group III. After 6 weeks, there was no significant change in testis weight and in total motility of all the three experimental groups, whereas, rapid moving spermatozoa, moderately moving spermatozoa and slow moving spermatozoa were significantly decreased in arsenic treated rats as compared to control rats. The other sperm principal parameters like progressiveness, average path velocity, straightness linear velocity (VSL), curvilinear velocity (VCL), straightness, linearity sperm head elongation ratio, area, linearity amplitude of lateral head department (ALH) and beat cross frequency (BCF) were found to be reduced in arsenic intoxicated rats. These results are not correlated with the histological studies. On oral administration of selenium ameliorated the adverse effects of arsenic as compared to arsenic alone treated rats. Our findings clearly demonstrate that administration of selenium could prevent some of the deleterious effects of arsenic in the testis.

Keywords

References

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