Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer

  • Yang, Ning-Ning (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Ma, Qing-Yun (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Huang, Sheng-Zhuo (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Dai, Hao-Fu (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Guo, Zhi-Kai (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Yu, Zhi-Fang (College of Food Science and Technology, Nanjing Agriculture University) ;
  • Zhao, You-Xing (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
  • Received : 2014.06.09
  • Accepted : 2014.07.05
  • Published : 2014.11.20
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Abstract

A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.

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References

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Cited by

  1. ChemInform Abstract: Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer. vol.46, pp.14, 2015, https://doi.org/10.1002/chin.201514257