Bulletin of the Korean Chemical Society

  • 제35권11호
  • /
  • Pages.3224-3226
  • /
  • 2014
  • /
  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
권호 표지
DOI QR코드

DOI QR Code

Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer

  • Yang, Ning-Ning (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Ma, Qing-Yun (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Huang, Sheng-Zhuo (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Dai, Hao-Fu (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Guo, Zhi-Kai (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS) ;
  • Yu, Zhi-Fang (College of Food Science and Technology, Nanjing Agriculture University) ;
  • Zhao, You-Xing (Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, CATAS)
  • 투고 : 2014.06.09
  • 심사 : 2014.07.05
  • 발행 : 2014.11.20
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.

키워드

참고문헌

  1. Mao, X. L. Macromycetes of China; Science Press: Beijing, China, 2009; Vol. 1, p 190.
  2. Jarrah, M. Y.; Thaller, V. J. Chem. Soc. Perkin Trans. 1983, 1, 1719.
  3. Holroyde, J. K.; Orr, A. F.; Thaller, V. J. C. S. Chem. Comm. 1976, 7, 242.
  4. Holroyde, J. K.; Orr, A. F.; Thaller, V. J. Chem. Soc. Perkin Trans. 1 1978, 12, 1490.
  5. Ellman, G. L.; Courtney, K. D.; Featherstone, R. M. Biochem. Pharmacol. 1961, 7, 88. https://doi.org/10.1016/0006-2952(61)90145-9
  6. Martin, M. B.; Mateos, A. F.; Gonzalez, R. R. J. Chem. Soc. Perkin Trans. 1 1995, 5, 569.
  7. Wu, S. H.; Chen, Y. W.; Miao, C. P. Isopimaric Diterpene Compounds and its Application: 201310298815.8, 2013.
  8. Wang, X. N.; Bashyal, B. P.; Wijeratne, E. M.; U'Ren, J. M.; Liu, M. X.; Gunatilaka, M. K.; Arnold, A. E.; Gunatilaka, A. A. J. Nat. Prod. 2011, 74, 2052. https://doi.org/10.1021/np2000864

피인용 문헌

  1. ChemInform Abstract: Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer. vol.46, pp.14, 2015, https://doi.org/10.1002/chin.201514257