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Remineralization effect of casein phosphopeptide-amorphous calcium fluoride phosphate on the tooth enamel according to the etching time and frequency of application

산부식 시간과 도포 횟수에 따른 불화 카제인포스포펩타이드-아모르포우스칼슘포스페이트의 치아 법랑질 재광화 효과

  • Jung, Su-Jin (Dept. of Dental Hygiene, Konyang University) ;
  • Lee, Mi-Ra (Dept. of Dental Hygiene, Baekseok Culture University)
  • Received : 2014.04.17
  • Accepted : 2014.09.11
  • Published : 2014.09.30

Abstract

This study examined the remineralization effect of CPP-ACFP according to the etching time and the frequency of application. A CPP-ACFP paste was formed from a combination of CPP-ACP paste and fluorine. The remineralization effect of CPP-ACFP was measured according to the etching time and the frequency of applications of CPP-ACFP. The microhardness of 64 teeth was measured as the sound sample and observed by scanning electron microscopy. As a result, the effect on remineralization of the enamel increased with increasing etching time and frequency of application. Therefore, a CPP-ACP paste combination to fluorine in the tooth mineral CPP-ACFP paste fluoride application can be supplied with the material-advisable enamel remineralization.

본 연구는 카제인포스포펩타이드-아모르포우스칼슘포스포페이트(CPP-ACP)에 불소이온을 결합시킨 불화 카제인포스포펩타이드-아모르포우스칼슘포스페이트(CPP-ACFP)제제의 법랑질 재광화 정도를 알아보기 위한 실험으로 법랑질 표면에 산부식 시간을 달리한 후 CPP-ACFP제제를 같은 횟수로 도포했을 때의 재광화 정도와 CPP-ACFP제제의 도포 횟수가 법랑질의 재광화에 미치는 영향을 알아보고자 건전한 치아 64개를 대상으로 미세경도측정, 주사전자현미경 관찰 실험을 하였다. 그 결과 산부식 시간이 길어질수록, CPP-ACFP제제의 도포 횟수를 증가시킬수록 법랑질의 재광화가 더 잘 일어나는 것을 관찰할 수 있었다. 그러므로 CPP-ACP에 불소이온을 결합시켜 치아에 무기질 공급과 불소도포를 한 번에 할 수 있는 CPP-ACFP제제는 법랑질 재광화 물질로 권장할 만하다고 하겠다.

Keywords

References

  1. J. D. Featherstone. "The continuum of dental caries evidence for a dynamic disease process", J Dent Res, 83, Spec No C:C39-42, 2004. https://doi.org/10.1177/154405910408301S08
  2. J. S. Kang, S. H. Lee, N. Y. Lee. "Remineralization effects by APF gel and CPP-ACP paste on incipient artificial caries enamel", J Korean Acad Pediatr Dent, 35(4), pp 684-691, 2008.
  3. G. B. Kim, N. G. Choi, S. M. Kim, K. H. Yang. "Comparative study of the remineralization effects using CPP-ACP and fluoride on the artificial enamel lesion", J Korean Acad Pediatr Dent, 36(1), pp 38-45, 2009.
  4. A. J. Roberts. "Role of models in assessing new agents for caries prevention - non-fluoride systems", Adv Dent Res, 9, pp 304-311, 1995. https://doi.org/10.1177/08959374950090031601
  5. R. K. Rose. "Binding characteristics of Streptococcus mutans for calcium and casein phosphopeptide", Caries Res, 34, pp 427-431, 2000. DOI: http://dx.doi.org/10.1159/000016618
  6. R. K. Rose. "Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques", Arch Oral Biol, 45, pp 569-575, 2000. DOI: http://dx.doi.org/10.1016/S0003-9969(00)00017-0
  7. Pediatric dentistry, The Korean Academy of Pediatric Dentistry, 4th ed, Seoul: Shinhung Internationale, pp 160-174, 2007.
  8. J. M. Graham, W. R. Hume. "Preservation and restoration tooth structure", Knowledge books and software queensland, pp 21-118, 2004.
  9. E. C. Reynolds. "Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions", J Dent Res, 76, pp 1587-1595, 1997. DOI: http://dx.doi.org/10.1177/00220345970760091101
  10. E. C. Reynolds. "Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides a review", Spec Care Dentist, 18, pp 8-16, 1998. DOI: http://dx.doi.org/10.1111/j.1754-4505.1998.tb01353.x
  11. B. I. Kim. "CPP-ACP introduction and clinical leverage", J Kor Dent Assoc, 46(3), pp 139-145, 2008.
  12. R. Z. LeGeros. "Calcium phosphate in oral biology and medicine", 1st ed. New York:Karger, pp 68-71, 1991.
  13. E. C. Reynolds, F. Cai, P. Shen and G. D. Walker. "Retention in plaque and remineralization of enamel lesion by various forms of calcium in mouthrinse or sugar-free chewing gum", J Dent Res, 82, pp 206-211, 2003. DOI: http://dx.doi.org/10.1177/154405910308200311
  14. P. Shen, F. Cai, A. Nowicki, J. Vincent and E. C. Reynolds. "Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate", J Dent Res, 80, pp 2066-2070, 2001. DOI: http://dx.doi.org/10.1177/00220345010800120801
  15. Y. Iijima, F. Cai, P. Shen, C. Reynolds, EC. Reynolds. "Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate", Caries Res, 38(6), pp 551-556, 2004. DOI: http://dx.doi.org/10.1159/000080585
  16. G. Walker, F. Cai, P. Shen, C. Reynolds, B. Ward, C. Fone. "Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate", J Dent Res, 73(1), pp 74-78, 2006.
  17. M. R. Lee, C. J. Lee, J. H. Park. "The Roughness & micro-hardness on the deciduous teeth according to formula milk or human milk", Int J Clin Prev Dent, 7(4), pp 179-188, 2011.
  18. Y. H. Kim, J. Y. Lee, M. K. Jeong. "The Erosion of the tooth enamel and the cementum by carbonate beverage", Int J Clin Prev Dent, 7(1), pp 1-13, 2011.
  19. S. Katz, K. K. Park and G. K. Stookey. "Development and initial testing of a model for in vitro formation of pit and fissure caries", Caries Res, 34, pp 424-428, 1986. DOI: http://dx.doi.org/10.1159/000260968
  20. N. J. Cochrane, S. Saranathan, F. Cai, K. J. Cross and E. C. Reynolds. "Enamel sub-surface lesion remineralization with casein phosphopeptide stabilised solutions of calcium, phosphate and fluoride", Caries Res, 42, pp 88-97, 2008. DOI: http://dx.doi.org/10.1159/000113161
  21. Y. S. Kim. "CPP-ACP of artificially demineralized enamel surface and remineralization of material containing nano-sized carbonated apatite", J Dent Hyg Soci, 8(1), pp 13-22, 2008.
  22. I. Zalizniak, J. E. A. Palamara, R. H. K. Wong, N. J. Cochrane, M. F. Burrow, E. C. Reynolds. "Ion release and physical properties of CPP-ACP modified GIC in acid solutions", J Dent Res, 41(5), pp 449-454, 2012. DOI: http://dx.doi.org/10.1016/j.jdent.2013.02.003
  23. C. P. Wang, S. B. Huang, Y. Liu, J. Y. Li, H. Y. Yu. "The CPP-ACP relieved enamel erosion from a carbonated soft beverage: An in vitro AFM and XRD study", Arch Oral Biol, 59(3), pp 277-282, 2013. DOI: http://dx.doi.org/10.1016/j.archoralbio.2013.11.018
  24. H. Hamba, T. Nikaido, G. Inoue, A. Sadr, J. Tagami. "Effects of CPP-ACP with sodium fluoride on inhibition of bovine enamel demineralization: A quantitative assessment using micro-computed tomography", J Dent Res, 39(6), pp 405-413, 2011. DOI: http://dx.doi.org/10.1016/j.jdent.2011.03.005
  25. M. J. Kim, S. H. Lee, N. Y. Lee, S. H. Park. "In vitro evaluation of experimental fluoride tape in inhibition of enamel dmineralization", J Korean Acad Pediatr Dent, 39(2), pp 129-138, 2012. DOI: http://dx.doi.org/10.5933/JKAPD.2012.39.2.129