Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet

  • Choi, Ha-Neul (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University) ;
  • Kang, Min-Jung (Food & Nutrition Research Team, Hurom Co., Ltd.) ;
  • Lee, Soo-Jin (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University) ;
  • Kim, Jung-In (Department of Smart Foods and Drugs, School of Food and Life Science, Inje University)
  • Received : 2014.02.04
  • Accepted : 2014.06.13
  • Published : 2014.10.01
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Abstract

BACKGROUND/OBJECTIVES: Obesity-associated insulin resistance is a strong risk factor for type 2 diabetes mellitus. The aim of this study was to investigate the effect of myricetin on adiposity, insulin resistance, and inflammatory markers in mice with diet-induced insulin resistance. MATERIALS/METHODS: Five-week-old male C57BL/6J mice were fed a basal diet, a high-fat, high-sucrose (HFHS) diet, or the HFHS diet containing 0.06% myricetin or 0.12% myricetin for 12 weeks after a 1-week adaptation, and body weight and food intake were monitored. After sacrifice, serum lipid profiles, glucose, insulin, adipocyte-derived hormones, and proinflammatory cytokines were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was determined. RESULTS: Myricetin given at 0.12% of the total diet significantly reduced body weight, weight gain, and epidydimal white adipose tissue weight, and improved hypertriglyceridemia and hypercholesterolemia without a significant influence on food intake in mice fed the HFHS diet. Serum glucose and insulin levels, as well as HOMA-IR values, decreased significantly by 0.12% myricetin supplementation in mice fed the HFHS diet. Myricetin given at 0.12% of the total diet significantly reduced serum levels of leptin, tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-6 (IL-6) in mice fed the HFHS diet. CONCLUSIONS: These findings suggest that myricetin may have a protective effect against diet-induced obesity and insulin resistance in mice fed HFHS diet, and that alleviation of insulin resistance could partly occur by improving obesity and reducing serum proinflammatory cytokine levels.

Keywords

References

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