Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antimicrobial Constituents from the Bacillus megaterium LC Isolated from Marine Sponge Haliclona oculata

  • Pham, Viet Cuong (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Nguyen, Thi Kim Cuc (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Vu, Thi Quyen (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Pham, Thanh Binh (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Phan, Van Kiem (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Nguyen, Hoai Nam (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)) ;
  • Nguyen, Tien Dat (Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST))
  • Received : 2014.04.02
  • Accepted : 2014.07.04
  • Published : 2014.09.30
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Abstract

Three compounds including 7,7-bis(3-indolyl)-p-cresol (1), cyclo-(S-Pro-R-Leu) (2) and cyclo-(S-Pro-R-Val) (3) were isolated from the strain of Bacillus megaterium LC derived from the marine sponge Haliclona oculata. All the isolated compounds showed antimicrobial activity at MIC values ranging from 0.005 to $5{\mu}g/mL$ against Gram-negative bacteria Vibrio vulnificus and V. parahaemolyticus, gram-positive bacteria Bacillus cereus and Micrococcus luteus, and the dermatophyte Trichophyton mentagrophytes. The results suggested that these compounds might have potential to be developed as agents treating dermatosis and controlling vibriosis in aquaculture.

Keywords

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