Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Evaluation of the Antioxidant Activities of Natural Components of Artemisia iwayomogi

  • Yan, Xi-Tao (College of Pharmacy, Chungnam National University) ;
  • Ding, Yan (School of Food Science and Technology, Dalian Polytechnic University) ;
  • Lee, Sang Hyun (Department of Food and Nutrition, Hannam University) ;
  • Li, Wei (School of Biotechnology, Yeungnam University) ;
  • Sun, Ya-Nan (College of Pharmacy, Chungnam National University) ;
  • Yang, Seo Young (College of Pharmacy, Chungnam National University) ;
  • Jang, Hae Dong (Department of Food and Nutrition, Hannam University) ;
  • Kim, Young Ho (College of Pharmacy, Chungnam National University)
  • Received : 2014.03.25
  • Accepted : 2014.05.08
  • Published : 2014.09.30
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초록

The antioxidant activities of 29 components isolated from the aerial parts of Artemisia iwayomogi were evaluated in vitro and in cell culture. Among the tested compounds, 2, 6, 8, 10, 13, and 14 exhibited the greatest peroxyl radical-scavenging activities in the oxygen radical absorbance capacity (ORAC) assay, and 2, 10, and 14 also showed significant reducing capacities. However, all compounds showed weak metal chelating activities. Their cellular antioxidant activities were evaluated in HepG2 cells. At $10{\mu}M$, compounds 6, 8, and 14 exhibited stronger protection against 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced oxidative stress than compounds 2, 10, and 13. Moreover, Compounds 2 and 8 were more effective in protecting against $Cu^{2+}$-induced oxidative stress than compounds 6, 10, 13, and 14 at $10{\mu}M$. These results suggest that the phenolic compounds in A. iwayomogi have the potential to be developed as natural antioxidants for the treatment of oxidative stress-related diseases.

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