Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Whitening Efficacy of Water Soluble Royal Jelly Removed Allergenic Protein

알러지 유발 단백질이 제거된 수용성 로열젤리의 피부미백 효과

  • Han, Sang Mi (National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Jung Min (National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Se Gun (National Academy of Agricultural Science, Rural Development Administration) ;
  • Jang, Hye Ri (National Academy of Agricultural Science, Rural Development Administration) ;
  • Yeo, Joo Hong (National Academy of Agricultural Science, Rural Development Administration) ;
  • Hong, In Pyo (National Academy of Agricultural Science, Rural Development Administration) ;
  • Woo, Soon Ok (National Academy of Agricultural Science, Rural Development Administration)
  • 한상미 (농촌진흥청 국립농업과학원) ;
  • 김정민 (농촌진흥청 국립농업과학원) ;
  • 김세건 (농촌진흥청 국립농업과학원) ;
  • 장혜리 (농촌진흥청 국립농업과학원) ;
  • 여주홍 (농촌진흥청 국립농업과학원) ;
  • 홍인표 (농촌진흥청 국립농업과학원) ;
  • 우순옥 (농촌진흥청 국립농업과학원)
  • Received : 2014.09.01
  • Accepted : 2014.09.23
  • Published : 2014.09.30
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Abstract

Royal jelly composes of many components, especially protein. Protein is a major factor which cause allergy. We focused on water soluble royal jelly (WSRJ) that was removed allergy - inducing protein. 10-hyroxy-2-decenoic acid content of WSRJ is 2.42 g/100 g, which is double compared to that of lypophilized RJ. To further access WSRJ as a cosmetic ingredient and potential external treatment for topical use, we investigated its ability to inhibit tyrosinase activity and melanin biosynthesis on melanogenesis in B16F1 melanoma cells. We found that WSRJ increased the cell viability in B16F1 melanoma cell and WSRJ (1~10 mg/ml) inhibited melanin synthesis in with 10 nM ${\alpha}$-melanocyte-stimulating hormone (${\alpha}$-MSH) for 48 h. WSRJ inhibited direct tyrosinase activity, which decreased melanin synthesis in ${\alpha}$-MSH stimulated B16F1 melanoma cells. Thease findings suggest that WSRJ induces the down regulation of melanogenesis by inhibiting tyrosinase activation.

Keywords

References

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