Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Hypoglycemic Effect of Paeonia lactiflora in High Fat Diet-Induced Type 2 Diabetic Mouse Model

고지방식이 유발 제2형 당뇨모델 마우스에서 작약의 혈당강하 효능

  • Yoon, In-Soo (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Jung, Yujung (Natural Medicine Center, KIST Gangneung Institute) ;
  • Kim, Hyun Jung (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Lim, Hyun Jin (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Cho, Seung-Sik (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Shim, Jung-Hyun (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University) ;
  • Kang, Bok Yun (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Cheon, Seung Hoon (College of Pharmacy and Research Institute of Drug Development, Chonnam National University) ;
  • Kim, Su-Nam (Natural Medicine Center, KIST Gangneung Institute) ;
  • Yoon, Goo (College of Pharmacy and Natural Medicine Research Institute, Mokpo National University)
  • 윤인수 (목포대학교 약학대학) ;
  • 정유정 (한국과학기술연구원 천연의약센터) ;
  • 김현정 (목포대학교 약학대학) ;
  • 임현진 (목포대학교 약학대학) ;
  • 조승식 (목포대학교 약학대학) ;
  • 심정현 (목포대학교 약학대학) ;
  • 강복윤 (전남대학교 약학대학) ;
  • 천승훈 (전남대학교 약학대학) ;
  • 김수남 (한국과학기술연구원 천연의약센터) ;
  • 윤구 (목포대학교 약학대학)
  • Received : 2014.06.17
  • Accepted : 2014.09.04
  • Published : 2014.09.30
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Abstract

The roots of Paeonia lactiflora (PL) has been traditionally used as analgesic, spasmolytic and tonic in Korea, China, and Japan. As part of a search for herbal medicine to treat diabetes and obesity, we confirmed hypoglycemic effect of PL through high fat diet-induced obese and diabetic mice experiments in vivo. Treatment of ethanolic extract from PL led to a significant decrease in glucose level, which is comparable to that of an antidiabetic drug metformin. In addition, PL selectively stimulates the transcriptional activities of both peroxisome proliferator-activated receptor $(PPAR){\alpha}$ and ${\gamma}$, and inhibits enzymatic activity of protein tyrosine phosphatase 1B (PTP1B), which are predicted to be therapeutic target in treatment of type2 diabetes and obesity. Especially, the n-hexane fraction (Hx) from PL ethanol extract showed more potent activities on $PPAR{\alpha}$ and than others and exihibited moderate inhibitory activity against PTP1B.

Keywords

References

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