Journal of Periodontal and Implant Science

  • 제44권4호
  • /
  • Pages.207-213
  • /
  • 2014
  • /
  • 2093-2278(pISSN)
  • /
  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지
DOI QR코드

DOI QR Code

Micronutrients and superoxide dismutase in postmenopausal women with chronic periodontitis: a pilot interventional study

  • Daiya, Sunita (Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences) ;
  • Sharma, Rajinder Kumar (Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences) ;
  • Tewari, Shikha (Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences) ;
  • Narula, Satish Chander (Department of Periodontics and Oral Implantology, Post Graduate Institute of Dental Sciences) ;
  • Sehgal, Paramjeet Kumar (Department of Blood & Transfusion Medicine, Pandit Bhagwat Dayal Sharma University of Health Sciences)
  • 투고 : 2014.03.18
  • 심사 : 2014.08.13
  • 발행 : 2014.08.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: The study was aimed at investigating changes in periodontal parameters and superoxide dismutase activity triggered by root surface debridement with and without micronutrient supplementation in postmenopausal women. Methods: Forty-three postmenopausal chronic periodontitis patients were divided into two groups: group 1 (n=22) were provided periodontal treatment in the form of scaling and root planing (SRP) and group 2 (n=21) patients received SRP along with systemic administration of micronutrient antioxidants. Patients in both groups were subjected to root surface debridement. Group 2 patients also received adjunctive micronutrient antioxidant supplementation. Serum and salivary superoxide dismutase (SOD) activity along with periodontal parameters were recorded at baseline and 3 months after therapy. Results: Salivary and serum SOD values significantly (P<0.05) improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group 2 as compared to group 1. Conclusions: Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women.

키워드

참고문헌

  1. Hopps E, Noto D, Caimi G, Averna MR. A novel component of the metabolic syndrome: the oxidative stress. Nutr Metab Cardiovasc Dis 2010;20:72-7. https://doi.org/10.1016/j.numecd.2009.06.002
  2. Iyer A, Fairlie DP, Prins JB, Hammock BD, Brown L. Inflammatory lipid mediators in adipocyte function and obesity. Nat Rev Endocrinol 2010;6:71-82. https://doi.org/10.1038/nrendo.2009.264
  3. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622. https://doi.org/10.1210/er.2001-0039
  4. Hadjigogos K. The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva Med 2003;45:7-13.
  5. Augustin AJ, Kirchhof J. Inflammation and the pathogenesis of age-related macular degeneration. Expert Opin Ther Targets 2009;13:641-51. https://doi.org/10.1517/14728220902942322
  6. Van der Velden U, Kuzmanova D, Chapple IL. Micronutritional approaches to periodontal therapy. J Clin Periodontol 2011;38 Suppl 11:142-58.
  7. Chapple IL. Potential mechanisms underpinning the nutritional modulation of periodontal inflammation. J Am Dent Assoc 2009;140:178-84. https://doi.org/10.14219/jada.archive.2009.0131
  8. Baltacioglu E, Akalin FA, Alver A, Balaban F, Unsal M, Karabulut E. Total antioxidant capacity and superoxide dismutase activity levels in serum and gingival crevicular fluid in post-menopausal women with chronic periodontitis. J Clin Periodontol 2006;33:385-92. https://doi.org/10.1111/j.1600-051X.2006.00923.x
  9. Vural P, Akgul C, Canbaz M. Effects of menopause and tibolone on antioxidants in postmenopausal women. Ann Clin Biochem 2005;42(Pt 3):220-3. https://doi.org/10.1258/0004563053857941
  10. Bednarek-Tupikowska G, Tupikowski K, Bidzinska B, Bohdanowicz-Pawlak A, Antonowicz-Juchniewicz J, Kosowska B, et al. Serum lipid peroxides and total antioxidant status in postmenopausal women on hormone replacement therapy. Gynecol Endocrinol 2004;19:57-63. https://doi.org/10.1080/09513590412331272328
  11. Brock GR, Butterworth CJ, Matthews JB, Chapple IL. Local and systemic total antioxidant capacity in periodontitis and health. J Clin Periodontol 2004;31:515-21. https://doi.org/10.1111/j.1600-051X.2004.00509.x
  12. Enwonwu CO, Ritchie CS. Nutrition and inflammatory markers. J Am Dent Assoc 2007;138:70-3. https://doi.org/10.14219/jada.archive.2007.0023
  13. Fredriksson M, Gustafsson A, Asman B, Bergstrom K. Hyper-reactive peripheral neutrophils in adult periodontitis: generation of chemiluminescence and intracellular hydrogen peroxide after in vitro priming and FcgammaR-stimulation. J Clin Periodontol 1998; 25:394-8. https://doi.org/10.1111/j.1600-051X.1998.tb02461.x
  14. Petelin M, Pavlica Z, Ivanusa T, Sentjurc M, Skaleric U. Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles. J Clin Periodontol 2000;27:918-25. https://doi.org/10.1034/j.1600-051x.2000.027012918.x
  15. Chapple IL. Oxidative stress, nutrition and neutrogenomics in periodontal health and disease. Int J Dent Hyg 2006;4 Suppl 1:15-21.
  16. Chapple IL, Milward MR, Ling-Mountford N, Weston P, Carter K, Askey K, et al. Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. J Clin Periodontol 2012;39:62-72. https://doi.org/10.1111/j.1600-051X.2011.01793.x
  17. Page RC, Eke PI. Case definitions for use in population-based surveillance of periodontitis. J Periodontol 2007;78(7 Suppl):1387-99. https://doi.org/10.1902/jop.2007.060264
  18. Loe H, Silness J. Periodontal disease in pregnancy: I. prevalence and severity. Acta Odontol Scand 1963;21:533-51. https://doi.org/10.3109/00016356309011240
  19. Silness J, Loe H. Periodontal disease in pregnancy: II. correlation between oral hygiene and periodontal condtion. Acta Odontol Scand 1964;22:121-35. https://doi.org/10.3109/00016356408993968
  20. Tamaki N, Tomofuji T, Ekuni D, Yamanaka R, Yamamoto T, Morita M. Short-term effects of non-surgical periodontal treatment on plasma level of reactive oxygen metabolites in patients with chronic periodontitis. J Periodontol 2009;80:901-6. https://doi.org/10.1902/jop.2009.080640
  21. Agnihotri R, Gaur S. Chemically modified tetracyclines: novel therapeutic agents in the management of chronic periodontitis. Indian J Pharmacol 2012;44:161-7. https://doi.org/10.4103/0253-7613.93841
  22. Singh A, Sharma RK, Siwach RC, Tewari S, Narula SC. Association of bone mineral density with periodontal status in postmenopausal women. J Investig Clin Dent 2013 Jun 14 [Epub]. http://dx.doi.org/10.1111/jicd.12047
  23. Singh N, Chander Narula S, Kumar Sharma R, Tewari S, Kumar Sehgal P. Vitamin E supplementation, superoxide dismutase status, and outcome of scaling and root planing in patients with chronic periodontitis: a randomized clinical trial. J Periodontol 2014;85:242-9. https://doi.org/10.1902/jop.2013.120727
  24. Kim SC, Kim OS, Kim OJ, Kim YJ, Chung HJ. Antioxidant profile of whole saliva after scaling and root planing in periodontal disease. J Periodontal Implant Sci 2010;40:164-71. https://doi.org/10.5051/jpis.2010.40.4.164
  25. Berger MM, Baines M, Raffoul W, Benathan M, Chiolero RL, Reeves C, et al. Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations. Am J Clin Nutr 2007;85:1293-300.
  26. Wang Y, Yang M, Lee SG, Davis CG, Kenny A, Koo SI, et al. Plasma total antioxidant capacity is associated with dietary intake and plasma level of antioxidants in postmenopausal women. J Nutr Biochem 2012;23:1725-31. https://doi.org/10.1016/j.jnutbio.2011.12.004
  27. Huang W, Glass CK. Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance. Arterioscler Thromb Vasc Biol 2010;30:1542-9. https://doi.org/10.1161/ATVBAHA.109.191189
  28. Rizvi M, Pathak D, Freedman JE, Chakrabarti S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med 2008;14:530-8. https://doi.org/10.1016/j.molmed.2008.09.006
  29. Opara EC, Rockway SW. Antioxidants and micronutrients. Dis Mon 2006;52:151-63. https://doi.org/10.1016/j.disamonth.2006.05.002
  30. Bozkurt S, Arikan DC, Kurutas EB, Sayar H, Okumus M, Coskun A, et al. Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation. J Pediatr Surg 2012;47:1735-41. https://doi.org/10.1016/j.jpedsurg.2012.03.053
  31. Chapple IL, Milward MR, Dietrich T. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations. J Nutr 2007;137:657-64. https://doi.org/10.1093/jn/137.3.657
  32. Linden GJ, McClean KM, Woodside JV, Patterson CC, Evans A, Young IS, et al. Antioxidants and periodontitis in 60-70-year-old men. J Clin Periodontol 2009;36:843-9. https://doi.org/10.1111/j.1600-051X.2009.01468.x
  33. Kushiyama M, Shimazaki Y, Murakami M, Yamashita Y. Relationship between intake of green tea and periodontal disease. J Periodontol 2009;80:372-7. https://doi.org/10.1902/jop.2009.080510
  34. Fridovich I. Superoxide anion radical (O2-.), superoxide dismutases, and related matters. J Biol Chem 1997;272:18515-7. https://doi.org/10.1074/jbc.272.30.18515
  35. Wei D, Zhang XL, Wang YZ, Yang CX, Chen G. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust Dent J 2010;55:70-8. https://doi.org/10.1111/j.1834-7819.2009.01123.x
  36. Misaki H, Suzuki M, Yoshie H, Hara K. The effect of superoxide dismutase on the inflammation induced by periodontal pathogenic bacteria and wound healing of gingival incision. Nihon Shishubyo Gakkai Kaishi 1990;32:93-110. https://doi.org/10.2329/perio.32.93
  37. Shingu M, Takahashi S, Ito M, Hamamatu N, Suenaga Y, Ichibangase Y, et al. Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats. Rheumatol Int 1994;14:77-81. https://doi.org/10.1007/BF00300251

피인용 문헌

  1. Trace Mineral Micronutrients and Chronic Periodontitis-a Review vol.176, pp.2, 2017, https://doi.org/10.1007/s12011-016-0832-y
  2. Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis vol.8, pp.None, 2017, https://doi.org/10.3389/fphys.2017.00351