Journal of the Korean Wood Science and Technology

The Korean Society of Wood Science & Technology (한국목재공학회)
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Inhibitory Effects of Camellia sinensis Extract on the Development of Atopic Dermatitis-like Lesions in NC/Nga Mice

  • Kim, Tae Hong (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Ha, Si Young (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University) ;
  • Yang, Jae-Kyung (Department of Environmental Materials Science, Institute of Agriculture & Life Science, Gyeongsang National University)
  • Received : 2014.02.13
  • Accepted : 2014.04.01
  • Published : 2014.09.25
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Abstract

Atopic dermatitis (AD) syndrome is one of the most common and severe skin diseases in Korea; a large population has this disease. We examined the effects of the extract from the leaf and sprig of Camellia sinensis on the development of AD by using NC mice as a model of atopic dermatitis. Oral administration of the extract to NC/Nga mice treated with 2,4?dinitrochlorobenzene (DNCB) inhibited the development of AD-like skin lesions as shown by a significant decrease in the skin symptoms of the disease and a decrease in ear thickness and levels of immunoglobulin E (IgE) and thymus-and activation-regulated chemokine (TARC) level in the skin. Administration of the extract markedly suppressed the DNCB-induced mRNA expression of interleukin 4 (IL-4) and tumor necrosis factor ${\alpha}$ (TNF-${\alpha}$). The findings suggest that transdermal application of the extract may modulate in the skin of NC/Nga mice. The extract was effective for the prevention and treatment of AD.

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References

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