Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Prevalence of Human Papillomavirus Infection in Oral Squamous Cell Carcinoma: a Case-control Study in Wuhan, China

  • Gan, Li-Li (Hubei-MOST KLOS & KLOBME, School and Hospital of Stomatology, Wuhan University) ;
  • Zhang, Hao (Department of Stomatology, The Central Hospital of Wuhan) ;
  • Guo, Ji-Hua (Hubei-MOST KLOS & KLOBME, School and Hospital of Stomatology, Wuhan University) ;
  • Fan, Ming-Wen (Hubei-MOST KLOS & KLOBME, School and Hospital of Stomatology, Wuhan University)
  • Published : 2014.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

High risk forms of the human papilloma virus (HPV) are generally accepted as necessary causative agents for cervical cancer. Recently, a possible relation between HPV and oral squamous cell carcinoma (OSCC) has also been noticed. The present study was conducted to investigate the prevalence of HPV infection in OSCCs in Wuhan city. DNA samples were collected from fresh tissues in 200 patients with OSCC and 68 normal controls. The polymerase chain reaction and direct sequencing were used to identify the HPV types in the samples. The prevalence of HPV of all types in the OSCC group was higher than in the control group (55/200 vs 2/68, OR=11.5, 95% CI=2.6-50.2). HPV16 and HPV18 were the main types detected, with HPV6 was the only low-risk type identified. High-risk HPV types HPV16 and HPV18 are prevalent in OSCC patients and may participate in the development of OSCC with traditional risk factors, tobacco and alcohol, possibly exerting synergistic effects. The results of multinomial logistic regression showed that those who smoked, consumed alcohol and with HPV infection have the highest risk of developing oral cancer (OR=13.3, 95% CI=3.1-56.8). Adjusted for age, smoking and alcohol use, HPV infection was independently associated with oral squamous cell carcinoma.

Keywords

References

  1. Anantharaman D, Chabrier A, Gaborieau V, et al (2014). Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India. PLoS One, 9, e88240. https://doi.org/10.1371/journal.pone.0088240
  2. Anaya-Saavedra G, Ramirez-Amador V, Irigoyen-Camacho M E, et al (2008). High association of human papillomavirus infection with oral cancer: a case-control study. Arch Med Res, 39, 189-97. https://doi.org/10.1016/j.arcmed.2007.08.003
  3. Argiris A, Karamouzis MV, Raben D, et al (2008). Head and neck cancer. Lancet, 371, 1695-709. https://doi.org/10.1016/S0140-6736(08)60728-X
  4. Chaturvedi AK, Engels EA, Anderson WF, et al (2008). Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States. J Clin Oncol, 26, 612-9. https://doi.org/10.1200/JCO.2007.14.1713
  5. Choi S, Myers JN (2008). Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res, 87, 14-32. https://doi.org/10.1177/154405910808700104
  6. D'Souza G, Kreimer AR, Viscidi R, et al (2007). Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med, 356, 1944-56. https://doi.org/10.1056/NEJMoa065497
  7. Fakhry C, Westra WH, Li S, et al (2008). Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst, 100, 261-9. https://doi.org/10.1093/jnci/djn011
  8. Gillison ML, Alemany L, Snijders PJ, et al (2012). Human papillomavirus and diseases of the upper airway: head and neck cancer and respiratory papillomatosis. Vaccine, 30 Suppl 5, F34-54.
  9. Gillison ML, Koch WM, Capone RB, et al (2000). Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer I, 92, 709-20. https://doi.org/10.1093/jnci/92.9.709
  10. Goot-Heah K, Kwai-Lin T, Froemming GR, et al (2012). Human papilloma virus 18 detection in oral squamous cell carcinoma and potentially malignant lesions using saliva samples. Asian Pac J Cancer Prev, 13, 6109-13. https://doi.org/10.7314/APJCP.2012.13.12.6109
  11. Hennessey PT, Westra WH, Califano JA (2009). Human papillomavirus and head and neck squamous cell carcinoma: recent evidence and clinical implications. J Dent Res, 88, 300-6. https://doi.org/10.1177/0022034509333371
  12. Herrero R, Castellsague X, Pawlita M, et al (2003). Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer I, 95, 1772-83. https://doi.org/10.1093/jnci/djg107
  13. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  14. Jemal A, Simard E P, Dorell C, et al (2013). Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)- associated cancers and HPV vaccination coverage levels. J Natl Cancer I, 105, 175-201. https://doi.org/10.1093/jnci/djs491
  15. Krishna Rao SV, Mejia G, Roberts-Thomson K, et al (2013). Epidemiology of oral cancer in Asia in the past decade--an update (2000-2012). Asian Pac J Cancer Prev, 14, 5567-77. https://doi.org/10.7314/APJCP.2013.14.10.5567
  16. Lace MJ, Anson JR, Klussmann JP, et al (2011). Human papillomavirus type 16 (HPV-16) genomes integrated in head and neck cancers and in HPV-16-immortalized human keratinocyte clones express chimeric virus-cell mRNAs similar to those found in cervical cancers. J Virol, 85, 1645-54. https://doi.org/10.1128/JVI.02093-10
  17. Lacey C J, Lowndes C M, Shah KV (2006). Chapter 4: Burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease. Vaccine, 24 Suppl 3, 35-41. https://doi.org/10.1016/j.vaccine.2006.06.015
  18. Lee LA, Huang CG, Liao CT, et al (2012). Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. PLoS One, 7, e40767. https://doi.org/10.1371/journal.pone.0040767
  19. Lin WJ, Jiang RS, Wu SH, Chen FJ, Liu SA (2011). Smoking, alcohol, and betel quid and oral cancer: a prospective cohort study. J Oncol, 2011, 525976.
  20. Loning T, Ikenberg H, Becker J, et al (1985). Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type related DNA. J Invest Dermatol, 84, 417-20. https://doi.org/10.1111/1523-1747.ep12265517
  21. Maden C, Beckmann AM, Thomas DB, et al (1992). Human papillomaviruses, herpes simplex viruses, and the risk of oral cancer in men. Am J Epidemiol, 135, 1093-102.
  22. Markopoulos AK (2012). Current aspects on oral squamous cell carcinoma. Open Dent J, 6, 126-30. https://doi.org/10.2174/1874210601206010126
  23. Marur S, D'Souza G, Westra WH, et al (2010). HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol, 11, 781-9. https://doi.org/10.1016/S1470-2045(10)70017-6
  24. Mitka M (2013). Evidence lacking for benefit from oral cancer screening. Jama, 309, 1884.
  25. Mondal R, Ghosh SK, Choudhury JH, et al (2013). Mitochondrial DNA copy number and risk of oral cancer: a report from Northeast India. PLoS One, 8, e57771. https://doi.org/10.1371/journal.pone.0057771
  26. Munoz N, Bosch FX, de Sanjose S, et al (2003). Epidemiologic classification of human papillomavirus types associated with cervical cancer. New Engl J Med, 348, 518-27. https://doi.org/10.1056/NEJMoa021641
  27. Pai SI, Westra WH (2009). Molecular pathology of head and neck cancer: implications for diagnosis, prognosis, and treatment. Annu Rev Pathol-Mech, 4, 49-70. https://doi.org/10.1146/annurev.pathol.4.110807.092158
  28. Pintos J, Black MJ, Sadeghi N, et al (2008). Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada. Oral Oncol, 44, 242-50. https://doi.org/10.1016/j.oraloncology.2007.02.005
  29. Psyrri A, DiMaio D (2008). Human papillomavirus in cervical and head-and-neck cancer. Nat Clin Pract Oncol, 5, 24-31. https://doi.org/10.1038/ncponc0984
  30. Schwartz SM, Daling JR, Doody DR, et al (1998). Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J Natl Cancer Inst, 90, 1626-36. https://doi.org/10.1093/jnci/90.21.1626
  31. Smith EM, Ritchie JM, Summersgill KF, et al (2004). Human papillomavirus in oral exfoliated cells and risk of head and neck cancer. J Natl Cancer Inst, 96, 449-55. https://doi.org/10.1093/jnci/djh074
  32. Syrjanen K, Syrjanen S, Lamberg M, et al (1983). Morphological and immunohistochemical evidence suggesting human papillomavirus (HPV) involvement in oral squamous cell carcinogenesis. Int J Oral Surg, 12, 418-24. https://doi.org/10.1016/S0300-9785(83)80033-7
  33. Syrjanen S (2010). The role of human papillomavirus infection in head and neck cancers. Ann Oncol, 21 Suppl 7, 243-5.
  34. Tachezy R, Klozar J, Rubenstein L, et al (2009). Demographic and risk factors in patients with head and neck tumors. J Med Virol, 81, 878-87. https://doi.org/10.1002/jmv.21470
  35. Termine N, Panzarella V, Falaschini S, et al (2008). HPV in oral squamous cell carcinoma vs head and neck squamous cell carcinoma biopsies: a meta-analysis (1988-2007). Ann Oncol, 19, 1681-90. https://doi.org/10.1093/annonc/mdn372
  36. Zhao D, Xu QG, Chen X M, et al (2009). Human papillomavirus as an independent predictor in oral squamous cell cancer. Int J Oral Sci, 1, 119-25. https://doi.org/10.4248/IJOS.09015
  37. Zhu C, Ling Y, Dong C, et al (2012). The relationship between oral squamous cell carcinoma and human papillomavirus: a meta-analysis of a Chinese population (1994-2011). PLoS One, 7, e36294. https://doi.org/10.1371/journal.pone.0036294
  38. Zygogianni AG, Kyrgias G, Karakitsos P, et al (2011). Oral squamous cell cancer: early detection and the role of alcohol and smoking. Head Neck Oncol, 3, 2. https://doi.org/10.1186/1758-3284-3-2

Cited by

  1. Expression of Vimentin and Ki-67 Proteins in Cervical Squamous Cell Carcinoma and their Relationships with Clinicopathological Features vol.16, pp.10, 2015, https://doi.org/10.7314/APJCP.2015.16.10.4271
  2. Saliva-Based Screening of High-Risk Human Papillomavirus Strains: Detection in Female Indonesian and Thai Dental Students vol.16, pp.13, 2015, https://doi.org/10.7314/APJCP.2015.16.13.5525
  3. Roles of Human Papillomaviruses and p16 in Oral Cancer vol.16, pp.15, 2015, https://doi.org/10.7314/APJCP.2015.16.15.6193
  4. Do Human Papilloma Viruses Play Any Role in Oral Squamous Cell Carcinoma in North Indians? vol.16, pp.16, 2015, https://doi.org/10.7314/APJCP.2015.16.16.7077
  5. Head and Neck Squamous Cell Carcinoma - Comparative Evaluation of Pathological Parameters in Young and Old Patients vol.16, pp.9, 2015, https://doi.org/10.7314/APJCP.2015.16.9.4061
  6. Absence of high-risk HPV 16 and 18 in Chinese patients with oral squamous cell carcinoma and oral potentially malignant disorders vol.13, pp.1, 2016, https://doi.org/10.1186/s12985-016-0526-2
  7. Oropharyngeal and laryngeal but not oral cancers are strongly associated with high-risk human papillomavirus in 172 Greek patients vol.89, pp.1, 2016, https://doi.org/10.1002/jmv.24614
  8. Human Papillomavirus in Head and Neck Squamous Cell Carcinoma vol.80, pp.4, 2018, https://doi.org/10.1007/s12262-016-1585-8
  9. Prevalence of human papillomavirus type-18 in head and neck cancer among the Chinese population vol.98, pp.8, 2019, https://doi.org/10.1097/MD.0000000000014551