Asian Pacific Journal of Cancer Prevention

  • 제15권14호
  • /
  • Pages.5701-5707
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Histopathological Diversity in Parotidectomy Materials in Turkish Population: Clinicopathologic Analysis and Demographic Features of 136 Cases in a Tertiary Care Hospital

  • Altinay, Serdar (Department of Pathology, Bagcilar Training and Research Hospital) ;
  • Taskın, Umit (Department of Ear-Nose-Throat Surgery, Bagcilar Training and Research Hospital) ;
  • Sar, Mehmet (Department of Pathology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital) ;
  • Aydin, Salih (Department of Ear-Nose-Throat Surgery, Bagcilar Training and Research Hospital) ;
  • Oktay, Mehmet Faruk (Department of Ear-Nose-Throat Surgery, Bagcilar Training and Research Hospital)
  • 발행 : 2014.07.30
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초록

Background: Salivary gland tumours, which account for approximately 3% of head-neck cancers, are a heterogeneous group and thus it is difficult to identify their epidemiological characteristics. The aim of this study is to determine demographic features and histopathologic distribution of parotid neoplasms in a large sample from Turkey. Materials and Methods: This study was conducted retrospectively on 136 parotidectomy materials from operations between May 2009-May 2013. Age, gender, tumor diameter, histopathological diagnosis and surgical margin status were recorded. Results: The benign cases were 112 (82.4%), while the malignancies were 24 (17.6%). The accuracy rate of FNAC was 91%. There were 46 (33.8%) male and 90 (66.2%) female patients. Female/male ratio (M/F=0.5) was two, the Warthin (WT) tumor being more apparent in males (p<0.05). Pleomorphic adenoma (PA) was detected most frequently among benign pathologies at 61.6% (69/112), while the Warthin Tumor (WT) was detected as the second most frequent tumor at 20.5% (23/112). Mucoepidermoid carcinoma (MEC) and carcinoma ex pleomorphic adenoma (Ca ex PA) were detected at equal frequency at 20.8% (5/24) among malign tumors. These were followed by acinic cell carcinoma at 16.7% (4/24). While the surgical margin was positive in ten patients with malignant tumors (41.7%), all of the benign tumors were negative (p<0.01). No significant difference was detected in the age-gender of patients, tumor size and distribution of sites among benign and malignant groups (p>0.05). Conclusions: Pleomorphic adenoma is the most frequently reported benign tumor almost in all global literature. Yet, the distribution of malignant tumors displays geographical differences. Based on these data, we believe that our findings will provide a significant contribution to future epidemiological studies. We think that it will be beneficial to generate awareness on parotid tumors and ensure a fight against smoking as with all head-neck cancers.

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참고문헌

  1. Ali NS, Nawaz A, Rajput S, Ikram M (2012). Parotidectomy: a review of 112 patients treated at a teaching hospital in Pakistan. Asian Pac J Cancer Prev, 11, 1111-3.
  2. Barnes L, Eveson JW, Reichart P, Sidransky D (2005). WHO Classification of Tumours. Pathology&Genetics of Head and Neck Tumours. In "Salivary Glands", eds Eveson JW, Auclair P, Gnepp DR, El-Naggar AK. IARC Press, Lyon, 209-281.
  3. Ellis GL, Auclair PL (2008). Tumors of the salivary glands. (AFIP Atlas of Tumor Pathology: Series 4) 4th ed. American Registry of Pathology, Washington.
  4. Flynn MB, Maguire S, Martinez S, Tesmer T (1999). Primary squamous cell carcinoma of the parotid gland: the importance of correct histological diagnosis. Ann Surg Oncol, 6, 768-70. https://doi.org/10.1007/s10434-999-0768-y
  5. Guintinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E (2006). Parotidectomy for benign parotid disease at a university teaching hospital: outcome of 963 operations. Laryngoscope, 116, 534-40. https://doi.org/10.1097/01.mlg.0000200741.37460.ea
  6. Gunizi H, Guney K (2013). Our surgical approach to parotid masses: an analysis of 130 patients. Kulak Burun Bogaz Ihtis Derg, 23, 85-9.
  7. Iqbal H, Bhatti AB, Hussain R, Jamshed A (2014). Ten year experience with surgery and radiation in the management of malignant major salivary gland tumors. Asian Pac J Cancer Prev, 15, 2195-9. https://doi.org/10.7314/APJCP.2014.15.5.2195
  8. Jaafari-Ashkavandi Z, Ashraf MJ, Moshaverinia M (2013). Salivary gland tumors: a clinicopathologic study of 366 cases in southern Iran. Asian Pac J Cancer Prev, 14, 27-30. https://doi.org/10.7314/APJCP.2013.14.1.27
  9. Kawata R, Lee K, Yoshimura K, Nishimawa S, Araki M (2012). Review of 300 cases of parotidectomy for benign parotid tumors. Nihon Jibiinkoka Gakkai Kaiho, 115, 618-24. https://doi.org/10.3950/jibiinkoka.115.618
  10. Kizil Y, Aydil U, Ekinci O, et al (2013). Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian J Otolaryngol Head Neck Surg, 65, 112-20. https://doi.org/10.1007/s12070-012-0594-6
  11. Lee YM, Choi HJ, Kim JW, Kim JH (2012). Parotid gland tumors in a Korean population. J Craniofac Surg, 23, 205-9. https://doi.org/10.1097/SCS.0b013e31824de357
  12. Lima RA, Tavares MR, Dias FL, et al (2005). Clinical prognostic factors in malignant parotid gland tumors. Otolaryngol Head Neck Surg, 133, 702-8. https://doi.org/10.1016/j.otohns.2005.08.001
  13. Lin CC, Tsai MH, Huang CC, et al (2008). Parotid tumors: a 10-year experience. Am J Otolaryngology-Head&Neck Med and Surg, 29, 94-100. https://doi.org/10.1016/j.amjoto.2007.03.002
  14. Maasland DH, van den Brandt PA, Kremer B, Goldbohm RA, Schouten LJ (2014). Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study. BMC Cancer, 14, 187. https://doi.org/10.1186/1471-2407-14-187
  15. Nouraei SA, Hope KL, Kelly CG, McLean NR, Soames JV (2005). Carcinoma ex benign pleomorphic adenoma of the parotid gland. Plast Reconstr Surg, 116, 1206-13. https://doi.org/10.1097/01.prs.0000181654.68120.0f
  16. Nguansangiam S, Jesdapatarakul S, Dhanarak N, Sosrisakorn K (2012). Accuracy of fine needle aspiration cytology of salivary gland lesions: routine diagnostic experience in Bangkok, Thailand. Asian Pac J Cancer Prev, 13, 1583-8. https://doi.org/10.7314/APJCP.2012.13.4.1583
  17. Salgarelli AC, Cappare P, Bellini P, et al (2009). Usefulness of fine-needle aspiration in parotid diagnostics. Oral Maxillofac Surg, 13, 185-90. https://doi.org/10.1007/s10006-009-0182-4
  18. Spiro RH (1986). Salivary neoplasms. Overview of a 35-year experience with 2807 patients. Head Neck Surg, 8, 177-84. https://doi.org/10.1002/hed.2890080309
  19. Sungur N, Akan IM, Ulusoy MG, et al (2002). Clinicopathological evaluation of parotid gland tumors: a retrospective study. J Craniofac Surg, 13, 26-30. https://doi.org/10.1097/00001665-200201000-00004
  20. Upton DC, McNamar JP, Connor NP, Harari PM, Hartig GK (2007). Parotidectomy: ten-year review of 237 cases at a single institution. Otolaryngol Head Neck Surg, 136, 788-92. https://doi.org/10.1016/j.otohns.2006.11.037
  21. Vargas PA, Gerhard R, Araujo Filho VJ, de Castro IV (2002). Salivary gland tumors in a Brazilian population: a retrospective study of 124 cases. Rev Hosp Clin Fac Med Sao Paulo, 57, 271-6.
  22. von Stritzky M, Wereldsma JC, Pegels JG (1998). Parotid mass as first symptom of a malignant lymphoma. J Surg Oncol, 67, 25-7. https://doi.org/10.1002/(SICI)1096-9098(199801)67:1<25::AID-JSO5>3.0.CO;2-O
  23. Wahlberg P, Anderson H, Biorklund A, Moller T, Perfekt R (2002). Carcinoma of the parotidand submandibular glands - a study of survival in 2465 patients. Oral Oncol, 38, 706-13. https://doi.org/10.1016/S1368-8375(02)00007-6
  24. Watanabe Y, Ishikawa M, Hojaku H, Mizukoshi K (1993). Facial nerve palsy as a complication of parotid gland surgery and its prevention. Acta Otolaryngologica, 504, 137-9.