Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Clinical Study on Safety of Cantharidin Sodium and Shenmai Injection Combined with Chemotherapy in Treating Patients with Breast Cancer Postoperatively

  • Wang, Lin (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research) ;
  • Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research) ;
  • Cao, Jie (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research)
  • Published : 2014.07.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives: To assess side effects on Cantharidin sodium and Shenmai injection combined with chemotherapy in treating patients with breast cancer postoperatively. Method: Patients with breast cancer receiving postoperative chemotherapy were retrospectively collected, and divided into four groups: group A with cantharidin sodium injection combined with chemotherapy; group B with Shenmai injection combined with chemotherapy; group C with both cantharidin sodium and Shenmai injection combined with chemotherapy; while group D (control group) received chemotherapy alone. All patients were administered docetaxel at a dose of $75mg/m^2$ on day 1, epirubicin hydrochloride at a dose of $60mg/m^2$ on day 1, and cyclophosphamide at a dose of $500mg/m^2$ on day 1 for 3 cycles (repeated at 21 day intervals). After ${\geq}$ three courses of treatment, quality of life and side effects were evaluated. Results: There were a total of 78 patients in this study, and the incidence of leukopenia and gastrointestinal reactions in groups A and B were lower than those in the control group and lowest in group C (p<0.05). Conclusions: Thus cantharidin sodium and Shenmai injection combined with chemotherapy reduce side effects and deserve to be further investigated in randomized clinical control trials.

Keywords

References

  1. Bajsa J, Pan Z, Duke SO (2011). Transcriptional responses to cantharidin, a protein phosphatase inhibitor, in Arabidopsis thaliana reveal the involvement of multiple signaltransduction pathways. Physiol Plant, 143, 188-205. https://doi.org/10.1111/j.1399-3054.2011.01494.x
  2. De Angelis V (2004). Activity, objective response, WHO and RECIST (Response Evaluation Criteria In Solid Tumor)evaluation criteria. Suppl Tumori, 3, 7-9.
  3. Deng QQ, Huang XE, Ye LH, et al (2013). Phase II Trial of $Loubo^{(R)}$ (Lobaplatin) and Pemetrexed for Patients with Metastatic Breast Cancer not Responding to Anthracycline or Taxanes. Asian Pac J Cancer Prev, 14, 413-7. https://doi.org/10.7314/APJCP.2013.14.1.413
  4. Gong P, Huang XE, Chen CY, et al (2012). Comparison oncomplications of peripherally inserted central catheters by ultrasound guide or conventional method in cancer patients. Asian Pac J Cancer Prev, 13, 1873-5. https://doi.org/10.7314/APJCP.2012.13.5.1873
  5. Gupta D, Lis CG, Grutsch JF (2007). The relationship between cancer-related fatigue and patient satisfaction with quality of life in cancer. J Pain Symptom Manage, 34, 40-7. https://doi.org/10.1016/j.jpainsymman.2006.10.012
  6. Hsieh CH, Huang YC, Tsai TH, Chen YJ (2011). Cantharidin modulates development of human monocyte-deriveddendritic cells. Toxicol In Vitro, 25, 1740-7. https://doi.org/10.1016/j.tiv.2011.09.001
  7. Huang SY, Cao KY (2010). Anti-invasive and anti-metastasis effect of norcantharidin on high-metastatic human breast cancer cell lines. J Trop Med, 9, 1034-45.
  8. Huang XE, Wei GL, Huo JG, et al (2013). Intrapleural or intraperitoneal lobaplatin for treatment of patients with malignant pleural effusion or ascites. Asian Pac J Cancer Prev, 14, 2611-4. https://doi.org/10.7314/APJCP.2013.14.4.2611
  9. Huang XE, Tian GY, Cao J, et al (2013). Pemetrexed as a component of first-, second- and third-line chemotherapy in treating patients with metastatic lung adenocarcinoma. Asian Pac J Cancer Prev, 14, 6663-7. https://doi.org/10.7314/APJCP.2013.14.11.6663
  10. Li CG, Huang XE, Xu L, et al (2012). Clinical application of serum tumor associated material (TAM) from non-small celllung cancer patients. Asian Pac J Cancer Prev, 13, 301-4. https://doi.org/10.7314/APJCP.2012.13.1.301
  11. Liu X-Y, Lai S-L, Guo X-F, Lao Y-R (2005). Shen-Mai injectionas an adjunct therapy to tumor chemotherapy a systematic review. Chinese J Evidence-Based Medicine, 1, 22-28.
  12. Liu J, Huang XE, Tian GY, et al (2013). Phase II Study on safetyand efficacy of $Yadanzi^{(R)}$ (Javanica oil emulsion injection) combined with chemotherapy for patients with gastric cancer. Asian Pac J Cancer Prev, 14, 2009-12. https://doi.org/10.7314/APJCP.2013.14.3.2009
  13. Lo LC, Chen CY, Chen ST, et al (2012). Therapeutic efficacy of traditional Chinese medicine, Shen-Mai San, in cancer patients undergoing chemotherapy or radiotherapy: study protocol for a randomized, double-blind, placebo-controlledtrial. Trials, 13, 232. https://doi.org/10.1186/1745-6215-13-232
  14. Qin CY, Maizhi Z (2000). Pattern, Cause, Pulse, and Treatment, Ancient Books of TCM, Beijing, China.
  15. Shi M, Shen Y (2012). Shenmai Injection for treatment of viral myocarditis: a meta-analysis. Chin Trad Patent Med, 10, 1882-6.
  16. Shen B, Zheng MQ, Lu JW, et al (2013). CXCL12-CXCR4 promotes proliferation and invasion of pancreatic cancercells. Asian Pac J Cancer Prev, 14, 5403-8. https://doi.org/10.7314/APJCP.2013.14.9.5403
  17. Shu JZ, Wang QR (2008). Meta analysis of the treatment for acute cerebral infarction with Shenmai injection andcompound salvia miltiorrhiza injection. Mod J Integ Trad Chin West Med, 17, 973-6.
  18. Siegel R, Naishadham D, Jemal A(2013). Cancer statistics, 2013. CA Cancer J Clin, 11, 11.30.
  19. Verma AK, Prasad SB (2012). Bioactive component, cantharidin from Mylabris cichorii and its antitumor activity against Ehrlich ascites carcinoma. Cell Biol Toxicol, 28, 133-47. https://doi.org/10.1007/s10565-011-9206-6
  20. Wang J, Zhang L (2011). The clinical effect of TE chemotherapyregime, with Shenmai injection in the treatment of advancedbreast cancer. J Pharmaceutical Practice, 3, 184-95.
  21. Wang JY, Liu GJ (2009). Eflect of norcantharidin on theexpression of VEGF mRNA in human breast cancer cell lines. Chin Arch Trad Chin Med, 11, 2369-73.
  22. Wang Y, Ma KF, Zhang XG, Hu YZ, Shentu JZ (2011). Shenmai Injection in coronary heart disease patients: a systematicreview and Meta-analysis. Chinese J Hospital Pharmacy, 15, 1314-7.
  23. Wu XY, Huang XE, You SX, et al (2013). Phase II study of pemetrexed as second or third line combined chemotherapy in patients with colorectal cancer. Asian Pac J Cancer Prev, 14, 2019-22. https://doi.org/10.7314/APJCP.2013.14.3.2019
  24. Xia CH, Sun JG, Wang GJ, et al (2010). Herb-drug interactions: in vivo and in vitro effect of shenmai injection, aherbal preparation, on the metabolic activities of hepaticcytochrome P450 3A1/2, 2C6, 1A2 and 2E1 in rats. Plant Medica, 76, 245-50. https://doi.org/10.1055/s-0029-1186082
  25. Yan HA, Shen K, Huang XE (2013). Clinical study on mannan peptide combined with TP regimen in treating patients with non-small cell lung cancer. Asian Pac J Cancer Prev, 14, 4801-4. https://doi.org/10.7314/APJCP.2013.14.8.4801
  26. Yu DS, Huang XE, Zhou JN, et al (2012). A comparative study on the value of anal preserving surgery for aged people with low rectal carcinoma in Jiangsu, China. Asian Pac J Cancer Prev, 13, 2339-40. https://doi.org/10.7314/APJCP.2012.13.5.2339
  27. Zhan YP, Huang XE, Cao J, et al (2012). Clinical study onsafety and efficacy of $Qinin^{(R)}$ (Cantharidin Sodium) injectioncombined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev, 13, 4773-6. https://doi.org/10.7314/APJCP.2012.13.9.4773
  28. Zhang WL, Yan TH, Liu B, et al (2011). Systematic reviews and Meta-analysis of Shenmai injection with chemotherapy on treatment of patients with NSCLC. Practical Pharmacy and Clinical Remedies, 2, 95-101.
  29. Zhang JH, Zhang G (2012). Clinical observation of Fufang Ban mao capsule for breast cancer patients neo-adjuvantchemotherapy. Chin J Clin Oncol Rehabil, 2-0147-03.

Cited by

  1. Irinotecan as a Palliative Therapy for Metastatic Breast Cancer Patients after Previous Chemotherapy vol.15, pp.24, 2014, https://doi.org/10.7314/APJCP.2014.15.24.10745
  2. Cantharidin Combined with Chemotherapy for Chinese Patients with Metastatic Colorectal Cancer vol.15, pp.24, 2014, https://doi.org/10.7314/APJCP.2014.15.24.10977
  3. Ginsenoside Rh2 differentially Mediates microRNA Expression to Prevent Chemoresistance of Breast Cancer vol.16, pp.3, 2015, https://doi.org/10.7314/APJCP.2015.16.3.1105
  4. Cantharidin Induced Oral Squamous Cell Carcinoma Cell Apoptosis via the JNK-Regulated Mitochondria and Endoplasmic Reticulum Stress-Related Signaling Pathways vol.11, pp.12, 2016, https://doi.org/10.1371/journal.pone.0168095
  5. Safety and Efficacy of a Mouth-Rinse with Granulocyte Colony Stimulating Factor in Patients with Chemotherapy-Induced Oral Mucositis vol.17, pp.1, 2016, https://doi.org/10.7314/APJCP.2016.17.1.413
  6. A Clinical Study on Juheli (Recombinant Human Interleukin - 11) in the Second Prevention of Chemotherapy Induced Thrombocytopenia vol.17, pp.2, 2016, https://doi.org/10.7314/APJCP.2016.17.2.485
  7. Shenmai injection enhances the cytotoxicity of chemotherapeutic drugs against colorectal cancers via improving their subcellular distribution vol.38, pp.2, 2017, https://doi.org/10.1038/aps.2016.99
  8. Cancer Chemotherapy Specific to Acidic Nests vol.9, pp.4, 2017, https://doi.org/10.3390/cancers9040036
  9. Effects of Shenmai injection on the values of CO, SV, and EF in patients undergoing off-pump coronary artery bypass graft vol.97, pp.10, 2018, https://doi.org/10.1097/MD.0000000000010085
  10. Shenmai injection improves the postoperative immune function of papillary thyroid carcinoma patients by inhibiting differentiation into Treg cells via miR-103/GPER1 axis pp.02724391, 2018, https://doi.org/10.1002/ddr.21459
  11. Ginseng: A Qualitative Review of Benefits for Palliative Clinicians pp.1938-2715, 2019, https://doi.org/10.1177/1049909118822704