Asian Pacific Journal of Cancer Prevention

  • 제15권15호
  • /
  • Pages.6103-6108
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

  • Zeng, Rong (Evidence-Based Medicine Center of Lanzhou University) ;
  • Duan, Lei (Evidence-Based Medicine Center of Lanzhou University) ;
  • Kong, Yu-Ke (The Second Hospital of Lanzhou University) ;
  • Wu, Xiao-Lu (The Second Hospital of Lanzhou University) ;
  • Wang, Ya (The Second Hospital of Lanzhou University) ;
  • Xin, Gang (The Second Hospital of Lanzhou University) ;
  • Yang, Ke-Hu (Evidence-Based Medicine Center of Lanzhou University)
  • 발행 : 2014.08.15
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초록

Many studies have reported ${\beta}$-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of ${\beta}$-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95%CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of ${\beta}$-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of ${\beta}$-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of ${\beta}$-catenin could be a predicative factor of poor prognosis for EC patients.

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피인용 문헌

  1. Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer vol.14, pp.1, 2016, https://doi.org/10.1186/s12957-016-0956-8