Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Histopathological Outcomes of Women with Abnormal Cervical Cytology: a Review of Literature in Thailand

  • Published : 2014.08.30
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Abstract

Cervical cytology remains the principal screening method to detect pre-invasive and invasive cervical lesions. Management of abnormal cervical cytology depends on the risk of encountering a significant cervical lesion or high-grade cervical disease. These risks may vary in different areas across the country. Thus, determining the rate of significant cervical lesion associated with each type of abnormal cervical cytology in each area is of critical importance for designing area-specific management approach. This review was conducted to evaluate the rate of high-grade cervical disease among Thai women with abnormal cervical cytology. A relatively high incidence of underlying significant lesions including invasive disease was demonstrated even in those having only minimal smear abnormality. This baseline information is crucial and must be taken into consideration in management of women with abnormal cytological screening to achieve the goals of comprehensive cervical cancer control in Thailand.

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References

  1. Adhya AK, Mahesha V, Srinivasan R, et al (2009). Atypical glandular cells in cervical smears: histological correlation and a suggested plan of management based on age of the patient in a low-resource setting. Cytopathology, 20, 375-9. https://doi.org/10.1111/j.1365-2303.2008.00629.x
  2. Alli PM, Ali SZ (2003). Atypical squamous cells of undetermined significance-rule out high-grade squamous intraepithelial lesion: cytopathologic characteristics and clinical correlates. Diagn Cytopathol, 28, 308-12. https://doi.org/10.1002/dc.10286
  3. ASCUS-LSIL Triage Study (ALTS) Group (2003). A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol, 188, 1393-400. https://doi.org/10.1016/S0002-9378(03)00413-7
  4. Aue-Aungkul A, Punyawatanasin S, Natprathan A, et al (2011). "See and treat" approach is appropriate in women with highgrade lesions on either cervical cytology or colposcopy. Asian Pac J Cancer Prev, 12, 1723-6.
  5. Barreth D, Schepansky A, Capstick V, et al (2006). Atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): a result not to be ignored. J Obstet Gynaecol Can, 28, 1095-8.
  6. Behtash N, Nazari Z, Fakhrejahani F, et al (2007). Clinical and histological significance of atypical glandular cell on Pap smear. Aust N Z J Obstet Gynaecol, 47, 46-9. https://doi.org/10.1111/j.1479-828X.2006.00678.x
  7. Berdichevsky L, Karmin R, Chuang L (2004). Treatment of highgrade squamous intraepithelial lesions: a 2- versus 3-step approach. Am J Obstet Gynecol, 190, 1424-6. https://doi.org/10.1016/j.ajog.2004.01.073
  8. Boardman LA, Weitzen S, Stanko C (2006). Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia. J Low Genit Tract Dis, 10, 140-5. https://doi.org/10.1097/00128360-200607000-00004
  9. Boman F, Duhamel A, Trinh DQ, et al (2004). Histological diagnosis after Pap smears detecting cancer or high-grade lesion of the cervix. Gynecol Obstet Fertil, 32, 404-8. https://doi.org/10.1016/j.gyobfe.2004.03.014
  10. Boonlikit S (2008). Prevalence of high-grade cervical lesion in women with LSIL and HSIL cytology and prevalence of invasive cancer in women cytologically positive for malignancy. Asian Pac J Cancer Prev, 9, 715-8.
  11. Charoenkwan K, Srisomboon J, Suprasert P, et al (2006). Histopathological outcomes of women with squamous cell carcinoma on cervical cytology. Asian Pac J Cancer Prev, 7, 403-6.
  12. Chatchotikawong U, Ruengkhachorn I,Laiwejpithaya S (2012). Factors predicting pathologic significance among women with atypical glandular cells on liquid-based cytology. Int J Gynaecol Obstet, 119, 30-4. https://doi.org/10.1016/j.ijgo.2012.05.027
  13. Chute DJ, Covell J, Pambuccian SE, et al (2006). Cytologichistologic correlation of screening and diagnostic Papanicolaou tests. Diagn Cytopathol, 34, 503-6. https://doi.org/10.1002/dc.20462
  14. Cooke A, Smith D, Booth A (2012). Beyond PICO: the SPIDER tool for qualitative evidence synthesis. Qual Health Res, 22, 1435-43. https://doi.org/10.1177/1049732312452938
  15. DeSimone CP, Day ME, Tovar MM, et al (2006). Rate of pathology from atypical glandular cell Pap tests classified by the Bethesda 2001 nomenclature. Obstet Gynecol, 107, 1285-91. https://doi.org/10.1097/01.AOG.0000218705.87329.4a
  16. Ekalaksananan T, Pientong C, Kongyingyoes B, et al (2011). Combined p16INK4a and human papillomavirus testing improves the prediction of cervical intraepithelial neoplasia (CIN II-III) in Thai patients with low-grade cytological abnormalities. Asian Pac J Cancer Prev, 12, 1777-83.
  17. Fairman A, Tan J, Quinn M (2004). Women with low-grade abnormalities on Pap smear should be referred for colposcopy. Aust N Z J Obstet Gynaecol, 44, 252-5. https://doi.org/10.1111/j.1479-828X.2004.00223.x
  18. Feng J, Husain M (2007). Outcomes of women with atypical squamous cells of undetermined significance and high-risk human papillomavirus DNA. Acta Cytol, 51, 730-4. https://doi.org/10.1159/000325835
  19. Haidopoulos DA, Stefanidis K, Rodolakis A, et al (2005). Histologic implications of Pap smears classified as atypical glandular cells. J Reprod Med, 50, 539-42.
  20. Ingkapairoj N, Luanratanakorn S, Chumworathayi B, et al (2012). Incidences of cervical intraepithelial neoplasia 2-3 or cancer pathologic diagnoses in patients with a high grade squamous intraepithelial lesion pap smear attending a colposcopy clinic at srinagarind hospital. Asian Pac J Cancer Prev, 13, 6203-6. https://doi.org/10.7314/APJCP.2012.13.12.6203
  21. Jones BA, Davey DD (2000). Quality management in gynecologic cytology using interlaboratory comparison. Arch Pathol Lab Med, 124, 672-81.
  22. Kantathavorn N, Phongnarisorn C, Srisomboon J, et al (2006). Northern Thai women with high grade squamous intraepithelial lesion on cervical cytology have high prevalence of underlying invasive carcinoma. Asian Pac J Cancer Prev, 7, 477-9.
  23. Kantathavorn N, Kietpeerakool C, Suprasert P, et al (2008). Clinical relevance of atypical squamous cells of undetermined significance by the 2001 bethesda system: experience from a cervical cancer high incidence region. Asian Pac J Cancer Prev, 9, 785-8.
  24. Khuakoonratt N, Tangjitgamol S, Manusirivithaya S, et al (2008). Prevalence of high grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer in patients with low grade squamous intraepithelial lesion (LSIL) at cervical pap smear. Asian Pac J Cancer Prev, 9, 253-7.
  25. Kiatiyosnusorn R, Suprasert P, Srisomboon J, et al (2010). Highgrade histologic lesions in women with low-grade squamous intraepithelial lesion cytology from a region of Thailand with a high incidence of cervical cancer. Int J Gynaecol Obstet, 110, 133-6. https://doi.org/10.1016/j.ijgo.2010.03.022
  26. Kiatpongsan S, Niruthisard S, Mutirangura A, et al (2006). Role of human papillomavirus DNA testing in management of women with atypical squamous cells of undetermined significance. Int J Gynecol Cancer, 16, 262-5. https://doi.org/10.1111/j.1525-1438.2006.00342.x
  27. Kietpeerakool C, Cheewakriangkrai C, Suprasert P, et al (2009). Feasibility of the 'see and treat' approach in management of women with 'atypical squamous cell, cannot exclude high-grade squamous intraepithelial lesion' smears. J Obstet Gynaecol Res, 35, 507-13. https://doi.org/10.1111/j.1447-0756.2008.00992.x
  28. Kingnate C, Tangjitgamol S, Khunarong J, et al (2014). Abnormal uterine cervical cytology in a large tertiary hospital in Bangkok metropolis: prevalence, management, and outcomes. Ind J Cancer, [Epub ahead of print].
  29. Levi AW, Kelly DP, Rosenthal DL, et al (2003). Atypical squamous cells of undetermined significance in liquid-based cytologic specimens: results of reflex human papillomavirus testing and histologic follow-up in routine practice with comparison of interpretive and probabilistic reporting methods. Cancer, 99, 191-7. https://doi.org/10.1002/cncr.11507
  30. Liman AK, Giampoli EJ, Bonfiglio TA (2005). Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing? Cancer, 105, 457-60. https://doi.org/10.1002/cncr.21387
  31. Lojindarat S, Luengmettakul J, Puangsa-Art S (2012). Clinical significance of atypical glandular cells in cervical Papanicolaou smears. J Med Assoc Thai, 95, 975-82.
  32. Louro AP, Roberson J, Eltoum I, et al (2003). Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion. A follow-up study of conventional and liquid-based preparations in a high-risk population. Am J Clin Pathol, 120, 392-7. https://doi.org/10.1309/NPU3WRQCTAB81XLW
  33. Massad LS, Collins YC, Meyer PM (2001). Biopsy correlates of abnormal cervical cytology classified using the Bethesda system. Gynecol Oncol, 82, 516-22. https://doi.org/10.1006/gyno.2001.6323
  34. Massad LS, Einstein MH, Huh WK, et al (2013). 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. Obstet Gynecol, 121, 829-46. https://doi.org/10.1097/AOG.0b013e3182883a34
  35. McHale MT, Souther J, Elkas JC, et al (2007). Is atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion clinically significant? J Low Genit Tract Dis, 11, 86-9. https://doi.org/10.1097/01.lgt.0000245039.45094.9a
  36. Moore MA, Attasara P, Khuhaprema T, et al (2010). Cancer epidemiology in mainland South-East Asia - past, present and future. Asian Pac J Cancer Prev, 11, 67-80.
  37. Numnum TM, Kirby TO, Leath CA 3rd, et al (2005). A prospective evaluation of "see and treat" in women with HSIL Pap smear results: is this an appropriate strategy? J Low Genit Tract Dis, 9, 2-6. https://doi.org/10.1097/00128360-200501000-00002
  38. Poomtavorn Y, Suwannarurk K, Thaweekul Y, et al (2011). Risk factors for high-grade cervical intraepithelial neoplasia in patients with atypical squamous cells of undetermined significance (ASC-US) Papanicolaou smears. Asian Pac J Cancer Prev, 12, 235-8.
  39. Pothisuwan M, Pataradool K, Tangjitgamol S, et al (2011). Visual inspection with acetic acid for detection of high grade lesion in atypical squamous cells and low grade squamous intraepithelial lesions from cervical Pap smear. J Gynecol Oncol, 22, 145-51. https://doi.org/10.3802/jgo.2011.22.3.145
  40. Quddus MR, Sung CJ, Steinhoff MM, et al (2001). Atypical squamous metaplastic cells: reproducibility, outcome, and diagnostic features on ThinPrep Pap test. Cancer, 93, 16-22. https://doi.org/10.1002/1097-0142(20010225)93:1<16::AID-CNCR9002>3.0.CO;2-A
  41. Rattanalappaiboon D, Kietpeerakool C, Kleebkaow P, et al (2014). Factors affecting compliance in the first year of postcolposcopy surveillance among women with a high incidence of cervical cancer. Int J Gynaecol Obstet, 124, 160-3. https://doi.org/10.1016/j.ijgo.2013.07.026
  42. Ruengkhachorn I, Laiwejpithaya S, Leelaphatanadit C, et al (2012). Clinicopathologic importance of women with squamous cell carcinoma cytology on Siriraj liquid-based cervical cytology. Asian Pac J Cancer Prev, 13, 4567-70. https://doi.org/10.7314/APJCP.2012.13.9.4567
  43. Saad RS, Dabbs DJ, Kordunsky L, et al (2006). Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women. Am J Clin Pathol, 126, 381-8. https://doi.org/10.1309/XVB01JQYQNM7MJXU
  44. Sadan O, Yarden H, Schejter E, et al (2007). Treatment of highgrade squamous intraepithelial lesions: a "see and treat" versus a three-step approach. Eur J Obstet Gynecol Reprod Biol, 131, 73-5. https://doi.org/10.1016/j.ejogrb.2005.12.025
  45. Safaeian M, Solomon D, Wacholder S, et al (2007). Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance. Obstet Gynecol, 109, 1325-31. https://doi.org/10.1097/01.AOG.0000263461.71732.40
  46. Sawangsang P, Sae-Teng C, Suprasert P, et al (2011). Clinical significance of atypical glandular cells on Pap smears: experience from a region with a high incidence of cervical cancer. J Obstet Gynaecol Res, 37, 496-500. https://doi.org/10.1111/j.1447-0756.2010.01387.x
  47. Scheungraber C, Kleekamp N, Schneider A (2004). Management of low-grade squamous intraepithelial lesions of the uterine cervix. Br J Cancer, 90, 975-8. https://doi.org/10.1038/sj.bjc.6601415
  48. Schnatz PF, Sharpless KE, O'Sullivan DM (2009). Use of human papillomavirus testing in the management of atypical glandular cells. J Low Genit Tract Dis, 13, 94-101. https://doi.org/10.1097/LGT.0b013e318183a438
  49. Selvaggi SM (2003). Reporting of atypical squamous cells, cannot exclude a high-grade squamous intraepithelial lesion (ASC-H) on cervical samples: is it significant? Diagn Cytopathol, 29, 38-41. https://doi.org/10.1002/dc.10303
  50. Selvaggi SM (2006). ASC-US and high-risk HPV testing: performance in daily clinical practice. Diagn Cytopathol, 34, 731-3. https://doi.org/10.1002/dc.20547
  51. Sherman ME, Solomon D, Schiffman M (2001). Qualification of ASCUS. A comparison of equivocal LSIL and equivocal HSIL cervical cytology in the ASCUS LSIL Triage Study. Am J Clin Pathol, 116, 386-94 https://doi.org/10.1309/JM3V-U4HP-W8HJ-68XV
  52. Sherman ME, Castle PE, Solomon D (2006). Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes. Cancer, 108, 298-305. https://doi.org/10.1002/cncr.21844
  53. Siddiqui MT, Hornaman K, Cohen C, et al (2008). ProEx C immunocytochemistry and high-risk human papillomavirus DNA testing in papanicolaou tests with atypical squamous cell (ASC-US) cytology: correlation study with histologic biopsy. Arch Pathol Lab Med, 132, 1648-52.
  54. Solomon D, Nayar R (2004). The Bethesda system for reporting cervical cytology (second ed.). New York: Springer-Verlage.
  55. Sripipattanakul M (2011). The see and treat approach in women with high-grade squamous intraepthelial lesion on Pap smear. Khon Kaen Med J, 35, 30-5.
  56. Srodon M, Parry Dilworth H, Ronnett BM (2006). Atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion: diagnostic performance, human papillomavirus testing, and follow-up results. Cancer, 108, 32-8.
  57. Suntornlimsiri W (2010). Women in a region with high incidence of cervical cancer warrant immediate colposcopy for atypical squamous cells of undetermined significance on cervical cytology. J Med Assoc Thai, 93, 676-681.
  58. Szurkus DC, Harrison TA (2003). Loop excision for high-grade squamous intraepithelial lesion on cytology: correlation with colposcopic and histologic findings. Am J Obstet Gynecol, 188, 1180-2. https://doi.org/10.1067/mob.2003.282
  59. Westin MC, Derchain SF, Rabelo-Santos SH, et al (2008). Atypical glandular cells and adenocarcinoma in situ according to the Bethesda 2001 classification: cytohistological correlation and clinical implications. Eur J Obstet Gynecol Reprod Biol, 139, 79-85. https://doi.org/10.1016/j.ejogrb.2007.08.017
  60. Zhao C, Florea A, Onisko A, et al (2009). Histologic follow-up results in 662 patients with Pap test findings of atypical glandular cells: results from a large academic womens hospital laboratory employing sensitive screening methods. Gynecol Oncol, 114, 383-9. https://doi.org/10.1016/j.ygyno.2009.05.019

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