Prevalence and Genotype Distribution of Human Papillomavirus among Women from Henan, China

  • Wang, Xiao-Chuan (Department of Clinical Laboratory, No. 150 Central Hospital of PLA) ;
  • Sun, Liang-Qi (Department of Clinical Laboratory, No. 150 Central Hospital of PLA) ;
  • Ma, Li (Department of Clinical Laboratory, No. 150 Central Hospital of PLA) ;
  • Li, Hua-Xin (Department of Clinical Laboratory, No. 150 Central Hospital of PLA) ;
  • Wang, Xiu-Li (Department of Clinical Laboratory, No. 150 Central Hospital of PLA) ;
  • Wang, Xin (Department of Obstetrics and Gynecology, No. 150 Central Hospital of PLA) ;
  • Yun, Tian (Department of pathology, No. 150 Central Hospital of PLA) ;
  • Meng, Nian-Long (Department of pathology, No. 150 Central Hospital of PLA) ;
  • Lv, Da-Le (Department of Clinical Laboratory, No. 150 Central Hospital of PLA)
  • Published : 2014.09.15


Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (${\chi}^2$=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).


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