대한치과교정학회지 (The korean journal of orthodontics)

  • 제44권5호
  • /
  • Pages.263-267
  • /
  • 2014
  • /
  • 2234-7518(pISSN)
  • /
  • 2005-372X(eISSN)
대한치과교정학회 (The Korean Association Of Orthodontists)
권호 표지
DOI QR코드

DOI QR Code

Micro-computed tomography analysis of changes in the periodontal ligament and alveolar bone proper induced by occlusal hypofunction of rat molars

  • Shimizu, Yasuhiro (Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University) ;
  • Hosomichi, Jun (Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University) ;
  • Nakamura, Saeko (Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University) ;
  • Ono, Takashi (Orthodontic Science, Department of Orofacial Development and Function, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University)
  • 투고 : 2013.11.25
  • 심사 : 2014.03.18
  • 발행 : 2014.09.25
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: To three-dimensionally elucidate the effects of occlusal hypofunction on the periodontal ligament and alveolar bone proper of rat molars by micro-computed tomography (micro-CT). Methods: Occlusal function in the molar area was restricted by attaching an anterior bite plate on the maxillary incisors and a metal cap on the mandibular incisors of 5-week-old male Wistar rats for 1 week. The periodontal ligament space and alveolar bone proper around roots of the mandibular first molar were assessed by histology and micro-CT. Results: The periodontal ligament space was narrower and the alveolar bone proper was sparser and less continuous in the hypofunction group than in the control group. Further, both the volume of the periodontal ligament and the volumetric ratio of the alveolar bone proper to the total tissue in the region of interest were significantly lower in the hypofunction group (p < 0.05). Conclusions: Occlusal hypofunction induces atrophic changes in the periodontal ligament and alveolar bone proper of rat molars.

키워드

참고문헌

  1. Gault P, Black A, Romette JL, Fuente F, Schroeder K, Thillou F, et al. Tissue-engineered ligament: implant constructs for tooth replacement. J Clin Periodontol 2010;37:750-8.
  2. Sebaoun JD, Kantarci A, Turner JW, Carvalho RS, Van Dyke TE, Ferguson DJ. Modeling of trabecular bone and lamina dura following selective alveolar decortication in rats. J Periodontol 2008;79:1679-88. https://doi.org/10.1902/jop.2008.080024
  3. Devlin H, Sloan P. Early bone healing events in the human extraction socket. Int J Oral Maxillofac Surg 2002;31:641-5. https://doi.org/10.1054/ijom.2002.0292
  4. Gay IC, Chen S, MacDougall M. Isolation and characterization of multipotent human periodontal ligament stem cells. Orthod Craniofac Res 2007;10: 149-60. https://doi.org/10.1111/j.1601-6343.2007.00399.x
  5. Hayashi Y, Iida J, Warita H, Soma K. Effects of occlusal hypofunction on the microvasculature and endothelin expression in the periodontal ligaments of rat molars. Orthod Waves 2001;60:373-80.
  6. Tanaka A, Iida J, Soma K. Effect of hypofunction on the microvasculature in the periodontal ligament of the rat molar. Orthodontic Waves 1998;57:180-8.
  7. Muramoto T, Takano Y, Soma K. Time-related changes in periodontal mechanoreceptors in rat molars after the loss of occlusal stimuli. Arch Histol Cytol 2000;63:369-80. https://doi.org/10.1679/aohc.63.369
  8. Enokida M, Kaneko S, Yanagishita M, Soma K. Inference of occlusal stimuli on the remodelling of alveolar bone in a rat hypofunction-recovery model. J Oral Biosci 2005;47:321-34. https://doi.org/10.1016/S1349-0079(05)80015-5
  9. Shimomoto Y, Chung CJ, Iwasaki-Hayashi Y, Muramoto T, Soma K. Effects of occlusal stimuli on alveolar/jaw bone formation. J Dent Res 2007;86: 47-51. https://doi.org/10.1177/154405910708600107
  10. Shimizu Y, Hosomichi J, Kaneko S, Shibutani N, Ono T. Effect of sympathetic nervous activity on alveolar bone loss induced by occlusal hypofunction in rats. Arch Oral Biol 2011;56:1404-11. https://doi.org/10.1016/j.archoralbio.2011.05.004
  11. Motokawa M, Terao A, Karadeniz EI, Kaku M, Kawata T, Matsuda Y, et al. Effects of long-term occlusal hypofunction and its recovery on the morphogenesis of molar roots and the periodontium in rats. Angle Orthod 2013;83:597-604. https://doi.org/10.2319/081812-661.1
  12. Watarai H, Warita H, Soma K. Effect of nitric oxide on the recovery of the hypofunctional periodontal ligament. J Dent Res 2004;83:338-42. https://doi.org/10.1177/154405910408300413
  13. Bourrin S, Palle S, Genty C, Alexandre C. Physical exercise during remobilization restores a normal bone trabecular network after tail suspensioninduced osteopenia in young rats. J Bone Miner Res 1995;10:820-8.
  14. Vignery A, Baron R. Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec 1980;196:191-200. https://doi.org/10.1002/ar.1091960210
  15. Johnson RB. Effect of altered occlusal function on transseptal ligament and new bone thicknesses in the periodontium of the rat. Am J Anat 1990;187: 91-7. https://doi.org/10.1002/aja.1001870110
  16. Meeran NA. Cellular response within the periodontal ligament on application of orthodontic forces. J Indian Soc Periodontol 2013;17:16-20. https://doi.org/10.4103/0972-124X.107468
  17. Mayahara K, Yamaguchi A, Takenouchi H, Kariya T, Taguchi H, Shimizu N. Osteoblasts stimulate osteoclastogenesis via RANKL expression more strongly than periodontal ligament cells do in response to PGE(2). Arch Oral Biol 2012;57:1377-84. https://doi.org/10.1016/j.archoralbio.2012.07.009
  18. Krishnan V, Davidovitch Z. Cellular, molecular, and tissue-level reactions to orthodontic force. Am J Orthod Dentofacial Orthop 2006;129:469.e1-32.

피인용 문헌

  1. Intermittent Hypoxia Influences Alveolar Bone Proper Microstructure via Hypoxia-Inducible Factor and VEGF Expression in Periodontal Ligaments of Growing Rats vol.7, pp.None, 2014, https://doi.org/10.3389/fphys.2016.00416
  2. Low-intensity pulsed ultrasound reduces periodontal atrophy in occlusal hypofunctional teeth vol.87, pp.5, 2014, https://doi.org/10.2319/121216-893.1
  3. Dental hypofunction alters subgingival microorganisms: a pilot study vol.68, pp.4, 2014, https://doi.org/10.23736/s0026-4970.19.04245-6