대한불안의학회지 (Anxiety and mood)

  • 제10권1호
  • /
  • Pages.44-51
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  • 2014
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  • 2586-0151(pISSN)
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  • 2586-0046(eISSN)
대한불안의학회 (Korean Academy of Anxiety Disorders)
권호 표지

사회불안장애에서 편도 하위영역의 내재 기능적 연결성의 특성

Characteristics of Intrinsic Functional Connectivity of Amygdalar Subregions in Social Anxiety Disorder

  • 김진성 (연세대학교 의과대학 의학행동과학연구소) ;
  • 윤형준 (연세대학교 의과대학 의학행동과학연구소) ;
  • 박선영 (연세대학교 강남세브란스병원 정신건강의학과) ;
  • 신유빈 (연세대학교 의과대학 의학행동과학연구소) ;
  • 김재진 (연세대학교 의과대학 의학행동과학연구소)
  • Kim, Jinseong (Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Yoon, Hyung-Jun (Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Park, Sunyoung (Department of Psychiatry, Yonsei University Gangnam Severance Hospital) ;
  • Shin, Yu-Bin (Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Kim, Jae-Jin (Institute of Behavioral Science in Medicine, Yonsei University College of Medicine)
  • 투고 : 2014.03.27
  • 심사 : 2014.04.18
  • 발행 : 2014.04.30
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초록

Objective : The amygdala has been considered to be a critical region in the pathophysiology of social anxiety disorder, but subregional connectivity pattern has not been examined yet despite lots of previous functional neuroimaging studies. Methods : Resting-state functional magnetic resonance imaging data was obtained in 19 patients with social anxiety disorder and 20 normal controls, and default mode functional connectivity with each of basolateral, centromedial and superficial areas of the amygdala was measured and compared between the two groups. Results : Differential amygdala-based networks between the two groups were distributed to all over the brain. In particular, however, a bias on the amygdala-cingulate pathway was observed in the superficial amygdala only. Connectivity strengths between the superficial amygdala and perigenual anterior cingulate cortex were correlated with scores of social interaction and avoidance. Conclusion : Our findings provide new insights into understanding of the intrinsic cognitive bias model of social anxiety disorder. An abnormality in superficial amygdala-anterior cingulate connectivity may influence on cognitive processing of socially-relevant information in social anxiety disorder.

키워드

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