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Degradation Efficiency and Characterization of Lincomycin by Electron Beam Irradiation

  • Received : 2014.07.17
  • Accepted : 2014.09.13
  • Published : 2014.09.30

Abstract

Lincomycin is one of the major species among the Pharmaceuticals and Personal Care Products (PPCPs) detected from the four major rivers in Korea. The structure characterization was performed of six degradation products of lincomycin formed under the irradiation of electron beam, and the degradation efficiency as a function of the various irradiation dose and sample concentration was investigated. Electron beam (10 MeV, 0.5 mA and 5 kW) experiments for the structural characterization of degradation products that are fortified with lincomycin, were performed at the dose of 10 kGy. The separation of degradation products and lincomycin was carried out using a C18 column ($2.1{\times}100$ mm, $3.5{\mu}m$), using gradient elution with 20 mM ammonium acetate and acetonitrile. The structures of six degradation products of lincomycin were proposed by interpretation of mass spectra and chromatograms by LC-MS/MS. The mass fragmentation pathways of mass spectra in tandem mass spectrometry were also proposed. Experiments were performed of the degradation efficiency as a function of the irradiation dose intensity and the initial concentration of lincomycin in an aqueous environment. In addition, increased degradation efficiency was observed with a higher dose of electron beam and lower concentration.

Keywords

References

  1. Wu, X.; Conkle, J. L.; Gan, J., J. Chromatogr. A 2012, 1254, 78. https://doi.org/10.1016/j.chroma.2012.07.041
  2. Richardson, S. D.; Ternes, T. A., Anal. Chem. 2005, 77, 3807. https://doi.org/10.1021/ac058022x
  3. Papich, M. G.; Riviere, J. E., Veterinary Pharmacology and Therapeutics, 9th Edn, Blackwell, US, 2009, 963.
  4. Albarellos, G. A.; Montoya, L.; Denamiel, G. A. A.; Velo, M. C.; Landoni, M. F., J. Vet. Pharmacol. Ther. 2012, 35, 534. https://doi.org/10.1111/j.1365-2885.2011.01355.x
  5. National Institute of Environmental Research: An investigation of pharmaceuticals exposure and health influences in environment, Kyonggi University, 2006.
  6. National Institute of Environmental Research: An investigation of pharmaceuticals exposure and health influences in environment (II), Kyonggi University, 2007.
  7. National Institute of Environmental Research: An analytical method development and monitoring of pharmaceuticals andpersonal care products (II), Kyonggi University, 2009.
  8. Ternes, T. A.; Joss, A.; Siegrist, H., Environ. Sci. Technol. 2004, 38, 392. https://doi.org/10.1021/es040639t
  9. Fent, K.; Escher, C.; Caminada, D., Reprod. Toxicol. 2006, 22, 175. https://doi.org/10.1016/j.reprotox.2006.04.010
  10. Kolpin, D. W.; Furlong, E. T.; Meyer, M. T.; Thurman, E. M.; Zaugg, S. D.; Barber, L. B.; Buxton, Environ. Sci. Technol. 2002, 36, 1202. https://doi.org/10.1021/es011055j
  11. Snyder, S. A.; Westerhoff, P.; Yoon, Y.; Sedlak, D. L., Environ. Sci. Technol. 2003, 20, 449.
  12. Krasner, S. W.; Westerhoff, P.; Chen, B.; Amy, A.; Nam, S. -N.; Chowdhury, Z. K.; Sinha, S.; Rittmann, B. E., Awwa Research Foundation 2008.
  13. Guo, Y. C.; Krasner, S. W., JAWRA 2009, 45, 58.
  14. Daughton, C. G.; Ternes, T. A., Environ. Health Persp. 1999, 107, 907 https://doi.org/10.1289/ehp.99107s6907
  15. Yu, C. -P.; Chu, K. -H., Chemosphere 2009, 75, 1281. https://doi.org/10.1016/j.chemosphere.2009.03.043
  16. Reyes-Contreras, C.; Matamoros, V.; Riuz, I.; Soto, M.; Bayona, J. M., Chemosphere 2011, 84, 1200. https://doi.org/10.1016/j.chemosphere.2011.06.003
  17. Kwon, M.; Yoon, Y.; Cho, E.; Jung, Y.; Lee, B. -C.; Paeng, K. -J, Kang, J. -W., J. Hazard. Mater. 2012, 126, 227.
  18. Wang, S. -M.; Bu, S. -S.; Liu, H. -M.; Li, H. -Y.; Liu, W.; Wang, Y. -D., Rapid Commun. Mass Spectrom. 2009, 23, 899. https://doi.org/10.1002/rcm.3935

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