Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes

  • Yu, Eun-Ah (Tongyeong National Quarantine Station, Ministry of Health & Welfare) ;
  • Cha, Chun-Nam (Department of Industrial Systems Engineering, Engineering Research Institute, Gyeongsang National University) ;
  • Park, Eun-Kee (Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University) ;
  • Yoo, Chang-Yeul (Department of Computer Information, Gyeongnam Provincial Namhae College) ;
  • Kim, Suk (College of Veterinary Medicine, Research Institute of Live Sciences, Gyeongsang National University) ;
  • Lee, Hu-Jang (Graduate School of Public Health, Gyeongsang National University)
  • Received : 2014.07.04
  • Accepted : 2014.09.05
  • Published : 2014.09.30
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Abstract

This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1 : 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were $20{\mu}g/mL$. Based on the time-kill curves for S. pyogenes, SGE was effective at $4{\times}$ MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.

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References

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