한국수산과학회지 (Korean Journal of Fisheries and Aquatic Sciences)

  • 제47권4호
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  • Pages.363-369
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  • 2014
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  • 0374-8111(pISSN)
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  • 2287-8815(eISSN)
한국수산과학회 (The Korean Society of Fisheries and Aquatic Science)
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효소 처리한 감태(Ecklonia cava) 분획물의 항비만 효과

The Effects of Anti-Obesity on Enzyme-treated Ecklonia cava Extracts

  • Kim, Seul-Young (Department of Food Science and Nutrition, Pukyong National University) ;
  • Yun, In-Jue (Ju Yeong NS Co., Ltd.) ;
  • Kwon, Chang-Ju (Ju Yeong NS Co., Ltd.) ;
  • Choi, Jung-Wook (Department of Food Science and Nutrition, Pukyong National University) ;
  • Kim, Young-Min (Department of Food Science and Nutrition, Pukyong National University) ;
  • Kang, Mi-Hye (Department of Food Science and Nutrition, Pukyong National University) ;
  • Lee, Min-Kyeong (Department of Food Science and Nutrition, Pukyong National University) ;
  • Nam, Taek-Jeong (Department of Food Science and Nutrition, Pukyong National University)
  • 투고 : 2014.07.25
  • 심사 : 2014.08.05
  • 발행 : 2014.08.31
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초록

Obesity is a worldwide problem that contributes to serious diseases, including diabetes, hypertension, and atherosclerosis. Recently, much research has examined functional natural materials and their anti-obesity activity. This study investigated the effect of enzyme-treated Ecklonia cava extracts on mice fed a high fat diet. To test the anti-obesity effects of a diet containing the enzyme-treated E. cava extracts (EEc), C57BL/6NTacSam mice were divided into six groups : normal diet (ND), high-fat diet (HFD), high-fat with Garcinia extract diet (GHD), and three high-fat with EEc diet (EHD250, EHD500, and EHD1000) groups. After 9 weeks, body weight was increased significantly in the HFD group compared to all of the EHD groups, and the weights of the liver, perirenal fat and epididymal fat paralleled the increase in body weight. The serum GOT, GPT, triglyceride, total cholesterol, and LDL-cholesterol levels were lower in the EHD1000 group than in the HFD group. The glucose and leptin concentrations were lowest in the EHD1000 group and C/EBP family expression was decreased in a dose-dependent manner. These results indicate that E. cava extracts not only have anti-oxidation functions but also anti-obesity effects.

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참고문헌

  1. Athukorala Y, Kim KN and Jeon YJ. 2006. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem Toxicol 44, 1065-1074. http://dx.doi.org/10.1016/j.fct.2006.01.011.
  2. Cho YM, Lee SM, Kim YH, Jeon GU, Sung JH, Jeong HS and Lee JS. 2010. Defatted grape seed extracts suppress adipogenesis in 3T3-L1 preadipocytes. J Korean Soc Food Sci Nutr 39, 927-931. https://doi.org/10.3746/jkfn.2010.39.6.927
  3. Cowherd RM, Lyle RE and McGehee Jr RE. 1999. Molecular regulation of adipocyte differentiation. Semin Cell Dev Biol 10, 3-10. https://doi.org/10.1006/scdb.1998.0276
  4. David LN and Michael MC. 2004. Principles of biochemistry, 4th edition, W.H. Freeman and Company, New York, U.S.A., 910-917.
  5. Friedman SF, Martin P and Munoz JS. 2003. Laboratory evaluation of the patient with liver disease. In: Hepatology, a textbook of liver disease. Zakim D and Boyer TD, eds. Saunders publication, Philadelphia, U.S.A., 661-709.
  6. Hong JH, Kim BK, Son BS, Chee HY, Lee BH, Shin HC, Lee KB and Song KS. 2006. Antihypertensive effect of Ecklonia cava extract. Kor Soc Pharm 37, 200-205
  7. Hong KH, Kang SA and Kim SH. 2001. Effects of high fat diet on serum leptin and insulin level and brown adipose tissue UCP1 expression in rats. Korean J Nutr 34, 865-871.
  8. Hong SY, Park JY, Sohn JS, Kim JH and Kim MK. 2009. Effects of garcinia cambogia extract feeding on body weight and lipid profiles in rats fed a high-carbohydrate or high-fat diet. Food Sci Biotechnol 18, 649-654.
  9. Imano H, Noda H, Kitamura A, Sato S, Kiyama M, Sankai T, Ohira T, Nakamura M, Yamagishi K, Ikeda A, Shimamoto T and Iso H. 2011. Low-density lipoprotein cholesterol and risk of coronary heart disease among Japanese men and women: the circulatory risk in communities study (CIRCS). Prev Med 52, 381-386. http://dx.doi.org/10.1016/j.ypmed.2011.02.019.
  10. Jang JY and Choi HJ. 2003. Effects of Artemisia Iwayomogi oligosaccharide on the blood Lipids, abdominal adipose tissues and leptin levels in the obese rats. Korean J Nutr 36, 437-445.
  11. Jung JY, Kim KBWR, Lee CJ, Kwak JH, Kim MJ, Kim DH, Sunwoo C, Kim TW and Ahn DH. 2011. Inhibitory effect of Ecklonia cava extracts against lipase activity and stability effect of temperature and pH on their activity. J Korean Soc Food Sci Nutr 40, 969-974. https://doi.org/10.3746/jkfn.2011.40.7.969
  12. Kang SR and Kim MY. 2009. The effect of Ecklonia cava extracts on bone turnover markers in ovariectomized rats. J Life Sci 19, 1841-1846. https://doi.org/10.5352/JLS.2009.19.12.1841
  13. Ko DU. 2004. Effect of Job's tears on the obesity range of rat. Ph.D. Thesis, Graduate School of Yongin University, Gyeonggi-do, Korea, 1-6.
  14. Kwon HJ. 2013. Biological activities and anti-obesity effect of Gam-Tae (Ecklonia cava). M.S. Thesis, Graduate School of Gyeongsang National University, Gyeongsangnam-do, Korea, 33-51.
  15. Lee HS, Choi JH, Kim YG and Lee CH. 2012. Effect of dietary intake of Salicornia herbacea L. hot water extract on anti-obesity in diet-induced obese rats. J Korea Soc Food Sci Nutr 41, 950-956. https://doi.org/10.3746/jkfn.2012.41.7.950
  16. Lee JJ, Park MR, Kim AR and Lee MY. 2011. Effects of ramie leaves on improvement of lipid metabolism and anti-obesity effect in rats fed a high fat/high cholesterol diet. Korean J Food Sci Technol 43, 83-90. https://doi.org/10.9721/KJFST.2011.43.1.083
  17. Lee KS, Choi YS and Seo JS. 2004. Sea tangle supplementation lowers blood glucose and support antioxidant systems in streptozotocin-induced diabetic rats. J Med Food 7, 130-135. https://doi.org/10.1089/1096620041223996
  18. Lee KS and Lee KY. 2011. Effect of Lotus (Nelumbo nucifera) leaf extract on serum and liver lipid levels of rats fed a high fat diet. J Korean Soc Food Sci Nutr 40, 1544-1547. https://doi.org/10.3746/jkfn.2011.40.11.1544
  19. Meier CA. 1995. Advances in the understanding of the molecular basis of obesity. Eur J Endocrinol 133, 761-763. https://doi.org/10.1530/eje.0.1330761
  20. Park JA, Park C, Han MH, Kim BW, Chung YH and Choi YH. 2011. Inhibition of adipocyte differentiation and adipogenesis by aged black garlic extracts in 3T3-L1 preadipocytes. J Life Sci 21, 720-728. https://doi.org/10.5352/JLS.2011.21.5.720
  21. Pi-Sunyer FX. 1991. Health implications of obesity. Am Soc Nutr 53, 15955-16035.
  22. Shin HC. 2011. Nutraceutical application of seanol. Food Industry and Nutrition 16, 5-11.
  23. Shin HC, Hwang HJ, Kang KJ and Lee BH. 2006. An anti-oxidative and antiinflammatory agent for potential treatment of osteoarthritis from Ecklonia cava. Arch pharm Res 29, 165-171. https://doi.org/10.1007/BF02974279
  24. Shin MK and Han SH. 2006. Effects of Lotus (Nelumbo Nucifera Gaertner) leaf powder on lipid concentrations in rats fed high fat diet rats. Korean Food Culture 21, 202-208.
  25. Sim JM. 2003. Studies on the nutritional evaluation of Ecklonia cava kjellman and Ecklonia Residues and their dietary effects on immunocompetence and productivity in chicken. Ph.D. Thesis, Graduate School of Konkuk University, Seoul, Korea, 1-20.
  26. Wi MY, Hwang EK, Kim SC, Hwang MS, Baek JM and Park CS. 2008. Regeneration and maturation induction for the free-living gametophytes of Ecklonia cava kjellman. J Korea Fish Soc 41, 381-388. https://doi.org/10.5657/kfas.2008.41.5.381

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