Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Protective Effect of Silkworm Hemolymph against Gamma Irradiation Induced Damage in the Liver of Mice

방사선 손상 Balb/C 마우스 모델에서 누에 체액(Silkworm Hemolymph)의 간조직 보호 효과

  • Nam, You Ree (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kang, Jung Ae (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Rho, Jong Kook (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Choi, Mi Hee (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Utami, Hayu Tyas (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Jang, Beom Su (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 남유리 (한국원자력연구원 첨단방사선연구소) ;
  • 강정애 (한국원자력연구원 첨단방사선연구소) ;
  • 노종국 (한국원자력연구원 첨단방사선연구소) ;
  • 최미희 (한국원자력연구원 첨단방사선연구소) ;
  • ;
  • 장범수 (한국원자력연구원 첨단방사선연구소) ;
  • 박상현 (한국원자력연구원 첨단방사선연구소)
  • Received : 2014.04.29
  • Accepted : 2014.05.19
  • Published : 2014.05.31

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Abstract

This study was designed to evaluate the protective effect of silkworm hemolymph against ${\gamma}-irradiation$ induced damage in the liver of mice. Female Balb/C mice (6 weeks old) were exposed to ${\gamma}-irradiation$ (6 Gy) and administered orally to silkworm hemolymph ($5ml\;kg^{-1}$ BW) for 7 days post-irradiation. The body weight, spleen index, plasma aspartate transaminase (AST), plasma alanine transaminase (ALT), and liver malondialdehyde (MDA) levels were determined. Compared with irradiated control mice, the activity of plasma AST and the level of MDA were significantly decreased in mice treated silkworm hemolymph. These results show that silkworm hemolymph is found to have a protective effect against ${\gamma}-irradiation$ induced damage in mice.

Keywords

Acknowledgement

Supported by : 한국연구재단