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Comparing High-Intensity Versus Low-to Moderate-Intensity Statin Therapy in Korean Patients with Acute Myocardial Infarction

한국인 심근경색증 환자에서 고강도 및 저·중강도 스타틴 치료에 따른 임상경과

  • Kim, Minah (Department of Cardiology, Chonnam National University Hospital) ;
  • Kim, Hyun Kuk (Department of Cardiology, Chonnam National University Hospital) ;
  • Ahn, Youngkeun (Department of Cardiology, Chonnam National University Hospital) ;
  • Park, Hyukjin (Department of Cardiology, Chonnam National University Hospital) ;
  • Jeong, Myung Ho (Department of Cardiology, Chonnam National University Hospital) ;
  • Cho, Jeong Gwan (Department of Cardiology, Chonnam National University Hospital) ;
  • Park, Jong Chun (Department of Cardiology, Chonnam National University Hospital) ;
  • Kim, Young Jo (Department of Cardiology, Yeungnam University Hospital) ;
  • Cho, Myeong Chan (Department of Cardiology, Chungbuk National University Hospital) ;
  • Kim, Chong Jin (Department of Cardiology, Kyunghee University Hospital)
  • 김민아 (전남대학교병원 순환기내과) ;
  • 김현국 (전남대학교병원 순환기내과) ;
  • 안영근 (전남대학교병원 순환기내과) ;
  • 박혁진 (전남대학교병원 순환기내과) ;
  • 정명호 (전남대학교병원 순환기내과) ;
  • 조정관 (전남대학교병원 순환기내과) ;
  • 박종춘 (전남대학교병원 순환기내과) ;
  • 김영조 (영남대학교병원 순환기내과) ;
  • 조명찬 (충북대학교병원 순환기내과) ;
  • 김종진 (경희대학교병원 순환기내과)
  • Received : 2014.12.05
  • Accepted : 2014.12.26
  • Published : 2014.06.30

Abstract

Objective: The aim of this study is to compare the clinical benefits between high-intensity and low-to moderate-intensity statin therapy in patients with acute myocardial infarction (AMI). Methods: A total of 1,230 patients in the Korea AMI Registry (KAMIR) were enrolled. Patients were divided into two groups according to the dosage of statin for the secondary prevention after AMI. The primary endpoint was composite of major adverse cardiac events (MACEs) including cardiac death, non-fatal MI, repeat revascularization during the 12 months of clinical follow-up. Result: The primary endpoint occurred in 101 patients (11.3%) from the low-to moderate-intensity statin group and 45 patients (13.4%) from the high-intensity statin group. The cumulative incidence of MACEs during 12-month follow-up was not significantly different between the two groups (p=0.323). After multi-variate analysis, MACEs-free survival rate was not significantly different between the two groups. Conclusion: High-intensity statin therapy did not show additional clinical benefit over low-to moderate-intensity statin therapy after AMI.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea, Ministry of Health & Welfare

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