DOI QR코드

DOI QR Code

Factors Affecting Dementia Prevalence in People Aged 60 or Over: A Community based Cross-sectional Study

60세 이상 성인의 치매 관련 영향요인: 지역사회 기반 단면연구

  • Kim, Seong Min (Department of Nursing, Seonam University, Namwon.Graduate school, Chosun University) ;
  • Seo, Hyun-Ju (Department of Nursing, College of Medicine, Chosun University) ;
  • Sung, Mi Ra (Department of Nursing, Yongin Songdam College.Seoul Metropolitan Center for Dementia)
  • 김성민 (서남대학교 의과대학 간호학과.조선대학교 대학원) ;
  • 서현주 (조선대학교 의과대학 간호학과) ;
  • 성미라 (용인송담대학교 간호과.서울특별시 광역치매센터)
  • Received : 2014.04.08
  • Accepted : 2014.06.28
  • Published : 2014.08.29

Abstract

Purpose: This study was done to examine the association between body mass index (BMI) and any type of clinical dementia. Methods: Participants were 60,321 people over 60 years of age enrolled in the Seoul Dementia Management Project in 2011. K-MMSE was used to classify participants as having a cognitive impairment and the Clinical Dementia Rating or DSM-IV by psychiatrists or neurologists to determine whether participants were in the dementia group or the non-dementia group. Descriptive statistics, chi-square test, and binary logistic regression analysis were performed. Results: In the univariate analysis, age, education level, living with spouse, BMI, alcohol consumption, and exercise were significantly associated with dementia. In multivariable analysis, increasing age was positively associated with dementia, and educational level was negatively associated with dementia. The exercise group had a lower prevalence of dementia than the non-exercise group. The odds ratio of dementia in the over-weight and obese groups compared to the normal group was 0.85 (95% CI 0.60, 0.98) and 0.64 (95%CI 0.46, 0.75), respectively. Conclusion: Results indicate that dementia is negatively associated with increasing BMI in people aged 60 years or older, but a prospective cohort study is needed to elucidate the causal effect relationship between BMI and dementia.

Keywords

References

  1. Statistics Korea. Elderly statistics 2010. Daejeon: Author; 2010.
  2. Cho MJ. The prevalence and risk factors of dementia in the Korean elderly. Health and Welfare Policy Forum. 2009;156:43-48.
  3. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: A systematic review and metaanalysis. Alzheimer's & Dementia. 2013;9(1):63-75. http://dx.doi.org/10.1016/j.jalz.2012.11.007
  4. Ministry of Health and Welfare. 2012 survey of dementia prevalence [Internet]. Seoul: Author; 2013 [cited 2013 August 16]. Available from: http://www.mw.go.kr/front_new/al/sal0301vw.jsp?PAR_MENU_ ID=04&MENU_ID=0403&page=1&CONT_SEQ=286138&SEARC HKEY=TITLE&SEARCHVALUE=dementia.
  5. Lee CN, Park KW. Risk factors of dementia. The Journal of Korean Diabetes. 2012;13(3):129-132. http://dx.doi.org/10.4093/jkd.2012.13.3.129
  6. Johnson DK, Wilkins CH, Morris JC. Accelerated weight loss may precede diagnosis in Alzheimer disease. Archives of Neurology. 2006;63(9):1312-1317. http://dx.doi.org/10.1001/archneur.63.9.1312
  7. Albanese E, Taylor C, Siervo M, Stewart R, Prince MJ, Acosta D. Dementia severity and weight loss: A comparison across eight cohorts. The 10/66 study. Alzheimer's & Dementia. 2013;9(6):649-656. http://dx.doi.org/10.1016/j.jalz.2012.11.014
  8. Gao S, Nguyen JT, Hendrie HC, Unverzagt FW, Hake A, Smith-Gamble V, et al. Accelerated weight loss and incident dementia in an elderly African-American cohort. Journal of the American Geriatrics Society. 2011;59(1):18-25. http://dx.doi.org/10.1111/j.1532-5415.2010.03169.x
  9. Xu WL, Atti AR, Gatz M, Pedersen NL, Johansson B, Fratiglioni L. Midlife overweight and obesity increase late-life dementia risk: A population- based twin study. Neurology. 2011;76(18):1568-1574. http://dx.doi.org/10.1212/WNL.0b013e3182190d09
  10. Ghaderpanahi M, Fakhrzadeh H, Sharifi F, Mirarefin M, Badamchizade Z, Larijani B, et al. Association between late-life body mass index, waist circumference, and dementia: Kahrizak elderly study. Journal of the American Geriatrics Society. 2012;60(1):173-174. http://dx.doi.org/10.1111/j.1532-5415.2011.03751.x
  11. Benito-Leon J, Mitchell AJ, Hernandez-Gallego J, Bermejo-Pareja F. Obesity and impaired cognitive functioning in the elderly: A population- based cross-sectional study (NEDICES). European Journal of Neurology. 2013;20(6):899-906. http://dx.doi.org/10.1111/ene.12083
  12. Anstey KJ, Cherbuin N, Budge M, Young J. Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies. Obesity Reviews. 2011;12(5):e426-e437. http://dx.doi.org/10.1111/j.1467-789X.2010.00825.x
  13. Kang Y, Na DL, Hahn S. A validity study on the Korean mini-mental state examination (K-MMSE) in dementia patients. Journal of the Korean Neurological Association. 1997;15(2):300-308.
  14. Lee YK, Sung MR, Lee DY. Comorbidity and health habits of Seoul city elders with dementia. Journal of Korean Academy of Nursing. 2011;41(3):411-422. http://dx.doi.org/10.4040/jkan.2011.41.3.411
  15. Lee JH, Lee KU, Lee DY, Kim KW, Jhoo JH, Kim JH, et al. Development of the Korean version of the consortium to establish a registry for Alzheimer's disease assessment packet (CERAD-K): Clinical and neuropsychological assessment batteries. The Journals of Gerontology Series B, Psychological Sciences and Social Sciences. 2002;57(1):P47-P53. https://doi.org/10.1093/geronb/57.1.P47
  16. Kang Y, Na DL. Seoul neuropsychological screening battery (SNSB) manual. Seoul: Human Brain Research & Consulting Co; 2003.
  17. Choi SH, Na DL, Lee BH, Hahm DS, Jeong JH, Yoon SJ, et al. Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale. Journal of the Korean Neurological Association. 2001;19(6):585-591.
  18. Chang WS, Won KH, Lee JY, Kim ET, Kweon HJ. The relationship between obesity and the high probability of dementia based on the body mass index and waist circumference. Korean Journal of Family Medicine. 2012;33(1):17-24. http://dx.doi.org/10.4082/kjfm.2012.33.1.17
  19. McDowell I, Xi G, Lindsay J, Tierney M. Mapping the connections between education and dementia. Journal of Clinical and Experimental Neuropsychology. 2007;29(2):127-141. http://dx.doi.10.1080/13803390600582420
  20. Sharp ES, Gatz M. Relationship between education and dementia: An updated systematic review. Alzheimer Disease and Associated Disorders. 2011;25(4):289-304. http://dx.doi.org/10.1097/WAD.0b013e318211c83c
  21. Lautenschlager NT, Cox KL, Flicker L, Foster JK, van Bockxmeer FM, Xiao J, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial. JAMA: the Journal of the American Medical Association. 2008;300(9):1027-1037. http://dx.doi.org/10.1001/jama.300.9.1027
  22. Forbes D, Thiessen EJ, Blake CM, Forbes SC, Forbes S. Exercise programs for people with dementia. Cochrane Database of Systematic Reviews. 2013;12:CD006489. http://dx.doi.org/10.1002/14651858.CD006489.pub3
  23. Gillette Guyonnet S, Abellan Van Kan G, Alix E, Andrieu S, Belmin J, Berrut G, et al. IANA (International Academy on Nutrition and Aging) expert group: Weight loss and Alzheimer's disease. The Journal of Nutrition, Health & Aging. 2007;11(1):38-48.
  24. Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus DH, Kukull W, et al. Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer Disease and Associated Disorders. 2014;28(1):36-43. http://dx.doi.org/10.1097/wad.0000000000000005

Cited by

  1. 지역사회 재가 노인의 인지수준에 영향을 미치는 신체상태와 기능 및 활동의 융합요인 vol.6, pp.6, 2015, https://doi.org/10.15207/jkcs.2015.6.6.153
  2. 독거노인의 치매 위험인자 보유상태가 인지기능 저하에 미치는 영향 vol.9, pp.8, 2018, https://doi.org/10.15207/jkcs.2018.9.8.265
  3. Associations Among Health Insurance Type, Cardiovascular Risk Factors, and the Risk of Dementia: A Prospective Cohort Study in Korea vol.16, pp.14, 2014, https://doi.org/10.3390/ijerph16142616