Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Synthesis of 125I-Labeled Hyaluronic Acid

방사성 히알루론산 합성

  • Ma, So-Young (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lee, Dong-Eun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute)
  • 마소영 (한국원자력연구원 첨단방사선연구소 생명공학연구부) ;
  • 이동은 (한국원자력연구원 첨단방사선연구소 생명공학연구부) ;
  • 박상현 (한국원자력연구원 첨단방사선연구소 생명공학연구부)
  • Received : 2014.07.17
  • Accepted : 2014.09.08
  • Published : 2014.09.30

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Abstract

Hyaluronic acid is a disaccharide polymer that consists of glucuronic acid and N-acetylglucosamine, and is a glycosaminoglycan. It is widely distributed in animal connective tissue, coexisting with chondroitin sulfate. It forms viscous secretions or gel by bonding to protein in the body, and thus maintains and lubricates tissue structures. In addition, its antibiotic properties are applied to cosmetics and pharmaceuticals. Therefore, it has recently been an object of great interest at cosmetic and pharmaceutical companies. $^{125}I$ has a longer half-life (59.4 days) than many other radioisotopes, and is therefore useful to long-term studies. In this study, a facile and efficient procedure for the synthesis of $^{125}I$-labeled hyaluronic acid has been designed for in vivo imaging and pharmacokinetic studies of hyaluronic acid, which are required for the development of new drugs.

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Acknowledgement

Supported by : 한국연구재단