The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Glycyrrhiza uralensis Fisch (GUF) Extract on the Ovalbumin-Induced Allergid Asthma in Mice

감초 추출물 투여가 Ovalbumin으로 유발된 마우스 알레르기성 천식에 미치는 영향

  • Jo, Eun-Hee (Dep. of Acupuncture and Moxibustion, Wonkwang University) ;
  • Jo, Il-Joo (Dep. of Herbology, Wonkwang University) ;
  • Park, Seong-Ju (Dep. of Herbology, Wonkwang University) ;
  • Jo, So-Hyun (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University) ;
  • Park, Min-Cheol (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Wonkwang University)
  • 조은희 (원광대학교 한의과대학 침구과) ;
  • 조일주 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 조소현 (원광대학교 한의과대학 안이비인후피부과) ;
  • 박민철 (원광대학교 한의과대학 안이비인후피부과)
  • Received : 2014.07.02
  • Accepted : 2014.08.15
  • Published : 2014.08.25
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Abstract

Objective : Glycyrrhiza uralensis Fisch (GUF) has been used as remedy of allergic diseases for a long time in Korea. In the present study, we investigated the anti-allergic effects of GUF on experimental allergic asthma mouse model using ovalbumin (OVA). Methods : BALB/c mice were sensitized and challenged with 100 ug of OVA and 1 mg of aluminum potassium sulfate of 0.2 ml phosphate-buffered saline (PBS) intraperitoneally on day 1 and 15. Mice were challenged on 3 consecutive days with 5% OVA and AHR was assessed 24 hrs after the last challenge. We examined total inflammatory cell number in bronchoaveloar lavage fluid (BALF), Th2-associated cytokine productions and lung histology. Results : GUF potently inhibited the development of airway hypersensitivity and also reduced the number of BAL cells during OVA-induced allergic asthma. GUF also inhibited cytokine productions such as IL-4, IL-13 in lung tissue. Furthermore, GUF treatment inhibited allergic airway inflammation. Conclusion : These results suggest that GUF may inhibit the production of IL-4, IL-13 and infiltration of inflammatory cell and be beneficial oriental medicine for allergic asthma.

Keywords

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