The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Ifosfamide-induced Fanconi syndrome with diabetes insipidus

  • Leem, Ah Young (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Kim, Han Sang (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Yoo, Byung Woo (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Kang, Beo Deul (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Kim, Min Hwan (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Rha, Sun Young (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Kim, Hyo Song (Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine)
  • Received : 2012.12.02
  • Accepted : 2014.01.04
  • Published : 2014.03.01
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Abstract

Ifosfamide-induced Fanconi syndrome is a rare complication that typically occurs in young patients due to a cumulative dose of ifosfamide > $40-60g/m^2$, a reduction in kidney mass, or concurrent cisplatin treatment. It is usually characterized by severe and fatal progression accompanied by type II proximal renal tubular dysfunction, as evidenced by glycosuria, proteinuria, electrolyte loss, and metabolic acidosis. Diabetes insipidus is also a rare complication of ifosfamide-induced renal disease. We herein describe a case involving a 61-year-old man who developed ifosfamide-induced Fanconi syndrome accompanied by diabetes insipidus only a few days after the first round of chemotherapy. He had no known risk factors. In addition, we briefly review the mechanisms and possible therapeutic options for this condition based on other cases in the literature. Patients who receive ifosfamide must be closely monitored for renal impairment to avoid this rare but fatal complication.

Keywords

References

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