The Korean journal of internal medicine

  • 제29권2호
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  • Pages.176-182
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  • 2014
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  • 1226-3303(pISSN)
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  • 2005-6648(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Urokinase, urokinase receptor, and plasminogen activator inhibitor-1 expression on podocytes in immunoglobulin A glomerulonephritis

  • Lee, Ji-Hye (Department of Pathology, Soonchunhyang University College of Medicine) ;
  • Oh, Mee-Hye (Department of Pathology, Soonchunhyang University College of Medicine) ;
  • Park, Jae-Seok (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Na, Gyoung-Jae (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Gil, Hye-Wook (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Yang, Jong-Oh (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Lee, Eun-Young (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Hong, Sae-Yong (Department of Internal Medicine, Soonchunhyang University College of Medicine)
  • 투고 : 2012.10.09
  • 심사 : 2013.05.23
  • 발행 : 2014.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: The purpose of this study was to investigate the expression of urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), and plasminogen activator inhibitor (PAI)-1 on podocytes in immunoglobulin A (IgA) glomerulonephritis (GN). Methods: Renal biopsy specimens from 52 IgA GN patients were deparaffinized and subjected to immunohistochemical staining for uPA, PAI-1, and uPAR. The biopsies were classified into three groups according to the expression of uPA and uPAR on podocytes: uPA, uPAR, and a negative group. The prevalences of the variables of the Oxford classification for IgA GN were compared among the groups. Results: On podocytes, uPA was positive in 11 cases and uPAR was positive in 38 cases; by contrast, PAI-1 was negative in all cases. Expression of both uPA and uPAR on podocytes was less frequently accompanied by tubulointerstitial fibrosis. Conclusions: Our results suggest a possible protective effect of podocyte uPA/uPAR expression against interstitial fibrosis.

키워드

참고문헌

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피인용 문헌

  1. Urokinase-type plasminogen activator receptor in IgA nephropathy vol.29, pp.2, 2014, https://doi.org/10.3904/kjim.2014.29.2.166
  2. Plasma Soluble Urokinase Receptor Level Is Correlated with Podocytes Damage in Patients with IgA Nephropathy vol.10, pp.7, 2014, https://doi.org/10.1371/journal.pone.0132869
  3. Functional networks of aging markers in the glomeruli of IgA nephropathy: a new therapeutic opportunity vol.7, pp.23, 2014, https://doi.org/10.18632/oncotarget.9033