Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease

  • Yan, Ji-Jing (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Ahn, Won-Gyun (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Jung, Jun-Sub (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Kim, Hee-Sung (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Hasan, Md. Ashraful (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Song, Dong-Keun (Department of Pharmacology, College of Medicine, Hallym University)
  • Received : 2013.08.14
  • Accepted : 2013.12.24
  • Published : 2014.08.01
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Abstract

BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of ${\beta}$-amyloid peptide ($A{\beta}$) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of $A{\beta}1$-42 until evaluation) effectively blocked $A{\beta}1$-42-induced impairment in passive avoidance performance, and $A{\beta}1$-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-$1{\alpha}$ in the hippocampus. In addition, it alleviated the $A{\beta}1$-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-$1{\beta}$ in the brain. CONCLUSIONS: The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.

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