Asian Pacific Journal of Cancer Prevention

  • 제15권10호
  • /
  • Pages.4207-4210
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Analysis of Common Genetic Variations in MUC5AC Gene with the Risk of Non-cardia Gastric Cancer in a Chinese Population

  • Zhou, Cheng-Jiang (School of Basic Medicine, Baotou Medical College) ;
  • Zhang, Liu-Wei (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) ;
  • Gao, Fang (School of Basic Medicine, Baotou Medical College) ;
  • Zhang, Bin (School of Basic Medicine, Baotou Medical College) ;
  • Wang, Ying (School of Basic Medicine, Baotou Medical College) ;
  • Chen, Da-Fang (Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center) ;
  • Jia, Yan-Bin (School of Basic Medicine, Baotou Medical College)
  • 발행 : 2014.05.30
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초록

Several lines of evidence suggest that genetic variation in MUC5AC gene might contribute to the risk of gastric cancer. We conducted a case-control study to evaluate the relationship between common genetic variations in MUC5AC gene and non-cardia gastric cancer using an LD-based tagSNP approach in Baotou, north-western China. We genotyped 12 tagSNPs by TaqMan method among 288 cases with non-cardia gastric cancer and 281 normal controls. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for non-cardia gastric cancer risk in association with alleles, genotypes and haplotypes. We observed that the frequencies of rs3793964 C allele and rs11040869 A allele were significantly lower in cases than in controls. Meanwhile, minor allele homozygotes of rs3793964 and rs11040869 were significantly associated with a decreased risk of non-cardia gastric cancer when compared with their major allele homozygotes. Furthermore, a statistically significantly protective effect of rs885454 genotypes on non-cardia gastric cancer was also observed (for CT vs. CC: OR=0.581, 95%CI=0.408-0.829; for CT/TT vs. CC: OR=0.623, 95%CI=0.451-0.884). Our results indicated that some common genetic variations in the MUC5AC gene might have effects on the risk of non-cardia gastric cancer in our studied population.

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피인용 문헌

  1. Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status vol.15, pp.24, 2015, https://doi.org/10.7314/APJCP.2014.15.24.10719
  2. Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases vol.32, pp.8, 2015, https://doi.org/10.1007/s10719-015-9606-6
  3. MUC1, MUC5AC, and MUC6 polymorphisms, Helicobacter pylori infection, and gastric cancer pp.0959-8278, 2017, https://doi.org/10.1097/CEJ.0000000000000348