Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage

  • Kim, Ki Cheon (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Piao, Mei Jing (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Zheng, Jian (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Yao, Cheng Wen (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Cha, Ji Won (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Kumara, Madduma Hewage Susara Ruwan (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Han, Xia (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Kang, Hee Kyoung (School of Medicine and Institute for Nuclear Science and Technology) ;
  • Lee, Nam Ho (Department of Chemistry, College of Natural Sciences, Jeju National University) ;
  • Hyun, Jin Won (School of Medicine and Institute for Nuclear Science and Technology)
  • Received : 2014.04.16
  • Accepted : 2014.06.11
  • Published : 2014.07.31
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Abstract

Fucodiphlorethol G (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from Ecklonia cava, a brown alga that is widely distributed offshore of Jeju Island. This study investigated the protective effects of fucodiphlorethol G against oxidative damage-mediated apoptosis induced by ultraviolet B (UVB) irradiation. Fucodiphlorethol G attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in response to UVB irradiation. Fucodiphlorethol G suppressed the inhibition of human keratinocyte growth by UVB irradiation. Additionally, the wavelength of light absorbed by fucodiphlorethol G was close to the UVB spectrum. Fucodiphlorethol G reduced UVB radiation-induced 8-isoprostane generation and DNA fragmentation in human keratinocytes. Moreover, fucodiphlorethol G reduced UVB radiation-induced loss of mitochondrial membrane potential, generation of apoptotic cells, and active caspase-9 expression. Taken together, fucodiphlorethol G protected human keratinocytes against UVB radiation-induced cell damage and apoptosis by absorbing UVB radiation and scavenging reactive oxygen species.

Keywords

References

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