Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Inhibitory Effects of Filiform Acupuncture and Laser Acupuncture at the Points of Zhongzhu($TE_3$).Zulinqi($GB_{41}$) on Neuropathic Pain in the Tibial and Sural Nerve Injury-induced Rats

중저(中渚)($TE_3$).임입(臨泣)($GB_{41}$) 침자 및 레이저침이 백서의 Tibial Nerve와 Sural Nerve 유발 동통 억제에 미치는 영향

  • Lee, Ju Hee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Lee, Dong Geun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Lee, Ook Jae (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Lee, Sang Hyun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Lee, Jung Hun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Jeong, Joo Yong (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Cheong, Min Seong (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Yang, Tae Jun (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Kim, Seon Wook (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University) ;
  • Cho, Myoung Rae (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Dongshin University)
  • 이주희 (동신대학교 한의과대학 침구의학교실) ;
  • 이동근 (동신대학교 한의과대학 침구의학교실) ;
  • 이욱재 (동신대학교 한의과대학 침구의학교실) ;
  • 이상현 (동신대학교 한의과대학 침구의학교실) ;
  • 이정훈 (동신대학교 한의과대학 침구의학교실) ;
  • 정주용 (동신대학교 한의과대학 침구의학교실) ;
  • 정민성 (동신대학교 한의과대학 침구의학교실) ;
  • 양태준 (동신대학교 한의과대학 침구의학교실) ;
  • 김선욱 (동신대학교 한의과대학 침구의학교실) ;
  • 조명래 (동신대학교 한의과대학 침구의학교실)
  • Received : 2014.05.26
  • Accepted : 2014.05.28
  • Published : 2014.06.20
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Abstract

Objectives : The purpose of this study was to investigate the analgesic effects of filiform acupuncture and laser acupuncture at the points of $TE_3{\cdot}GB_{41}$ in neuropathic pain induced rats. Methods : Neuropathic pain in rats was induced by partial resection of the tibial and sural nerves. Three weeks after the neuropathic surgery, each of the experimental groups(AT, LAT, AT + LAT and LAT + AT) was injected at the $TE_3{\cdot}GB_{41}$ twice per week for three weeks. Results : 1. All of the experimental groups(AT, LAT, AT + LAT and LAT + AT) showed a significant decrease in the plantar withdrawal response of allodynia and the thermal allodynia as compared with the control group. During the early phase, the AT and AT + LAT groups have been marked as more significant than the LAT + AT and LAT groups. 2. The expression of c-Fos significantly decreased in the LAT and LAT + AT groups as compared with the control group. 3. The LAT + AT group showed a significant decrease in Bax as compared with the control group. In each experimental groups(AT, LAT, AT + LAT and LAT + AT), Bcl-2 increased and Bax/Bcl-2 ratio decreased as compared with the control group. 4. The LAT, AT + LAT and LAT + AT groups showed a significant increase in mGluR5 as compared with the control group. Conclusions : These results represented that the filiform acupuncture and laser acupuncture at the $TE_3{\cdot}GB_{41}$ exerted anti-apoptotic and neuroprotective effects on the model of neuropathic pain, thereby suggesting that they should be available for decreasing mechanical allodynia.

Keywords

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