Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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The Effect of Hoelen Herbal-acupuncture at $KI_{10}$ on Lipopolysaccharide Induced Nephritis in Rats

음곡(陰谷) 백복령(白茯苓)약침이 Lipopolysaccharide로 유도된 흰쥐의 염증성 신(腎) 손상에 미치는 영향

  • Kim, Min Sik (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University) ;
  • Kim, Byung Soo (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University) ;
  • Yim, Yun Kyoung (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
  • 김민식 (대전대학교 한의과대학 한의학과 경락경혈학교실) ;
  • 김병수 (대전대학교 한의과대학 한의학과 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 한의학과 경락경혈학교실)
  • Received : 2014.05.13
  • Accepted : 2014.06.03
  • Published : 2014.06.20
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Abstract

Objectives : The purpose of this study is evaluating the effect of Hoelen Herbal-acupuncture (HO-HA) at $KI_{10}$(Umgok) on Lipopolysaccharide(LPS) induced nephritis in rats. Methods : The experimental rats were assigned to four groups; normal, LPS, saline, HO-HA groups. LPS(2 mg/kg) was administered to the rats in LPS, saline and HO-HA groups to induce acute inflammatory kidney damage. Saline injection and HO-HA were administered at $KI_{10}$ three times a week. Blood samples were taken from the rats for analysis of white blood cell(WBC), neutrophil, blood urea nitrogen(BUN), creatinine TNF-${\alpha}$, CINC-1. Urine samples were taken from the rats for analysis of urinal volume, creatinine and total protein. The kidney samples were taken from the rats for analysis of renal myeloperoxIdase(MPO). Results : HO-HA suppressed the increases of WBC and neutrophils in blood, BUN, creatinine, TNF-${\alpha}$ and CINC-1 in serum, and MPO in kidney of LPS-stimulated rats. In addition, HO-HA inhibited the decrease of urinary volume in LPS-stimulated rats. Conclusions : HO-HA has therapeutic effects on LPS-induced inflammatory kidney damage in rats. Further studies may be needed for clinical use of HO-HA.

Keywords

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