Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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Facial Transplantation Surgery

  • Eun, Seok Chan (Department of Plastic and Reconstructive Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine)
  • Received : 2013.12.26
  • Accepted : 2013.12.26
  • Published : 2014.03.15
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Abstract

It is well known that patients with severe facial injuries accompanied by facial disfiguration are vulnerable to a poor quality of life. With the help of facial transplantation, it has become possible to achieve an optimal anatomical reconstruction. As compared to conventional methods, it can provide more desirable functional, aesthetic, and psychosocial outcomes. Face transplantation surgeons need to consider many problems associated with the criteria for selecting patients, techniques for harvesting the donor tissue, prediction of the expected functional outcomes, limitations in obtaining written informed consent for conducting the procedure, evaluation of the post-transplant immunological response and postoperative immunosuppressant requirements, psychological and social outcomes for the patients, and other concerns about funding and ethical issues.

Keywords

References

  1. Siemionow M, Ozturk C. Face transplantation: outcomes, concerns, controversies, and future directions. J Craniofac Surg 2012;23:254-9. https://doi.org/10.1097/SCS.0b013e318241b920
  2. Brandacher G. Composite tissue transplantation. Methods Mol Biol 2013;1034:103-15. https://doi.org/10.1007/978-1-62703-493-7_5
  3. Lantieri L. Face transplant: a paradigm change in facial reconstruction. J Craniofac Surg 2012;23:250-3. https://doi.org/10.1097/SCS.0b013e318241c10b
  4. Gordon CR, Siemionow M, Papay F, et al. The world's experience with facial transplantation: what have we learned thus far? Ann Plast Surg 2009;63:572-8. https://doi.org/10.1097/SAP.0b013e3181ba5245
  5. Giuglea C, Coman C, Marinescu S, et al. Transplantation of composite tissue allograft: scientific bases and clinical applications. J Med Life 2013;6:40-4.
  6. Shanmugarajah K, Hettiaratchy S, Butler PE. Facial transplantation. Curr Opin Otolaryngol Head Neck Surg 2012; 20:291-7. https://doi.org/10.1097/MOO.0b013e3283552cc5
  7. Pomahac B, Pribaz J. Facial composite tissue allograft. J Craniofac Surg 2012;23:265-7. https://doi.org/10.1097/SCS.0b013e318241b8b8
  8. Pomahac B, Nowinski D, Diaz-Siso JR, et al. Face transplantation. Curr Probl Surg 2011;48:293-357. https://doi.org/10.1067/j.cpsurg.2011.01.003
  9. Ruegg EM, Hivelin M, Hemery F, et al. Face transplantation program in France: a cost analysis of five patients. Transplantation 2012;93:1166-72. https://doi.org/10.1097/TP.0b013e31824e75fa
  10. Siemionow M, Gatherwright J, Djohan R, et al. Cost analysis of conventional facial reconstruction procedures followed by face transplantation. Am J Transplant 2011;11:379-85. https://doi.org/10.1111/j.1600-6143.2010.03373.x
  11. Bueno EM, Diaz-Siso JR, Pomahac B. A multidisciplinary protocol for face transplantation at Brigham and Women's Hospital. J Plast Reconstr Aesthet Surg 2011;64:1572-9. https://doi.org/10.1016/j.bjps.2011.07.008
  12. Billington D, Chard PS, Clayton M. Effects of butylated hydroxytoluene upon protein transport in the isolated perfused rat liver. Biochem Pharmacol 1990;39:1624-7. https://doi.org/10.1016/0006-2952(90)90532-P
  13. Singhal D, Pribaz JJ, Pomahac B. The Brigham and Women's Hospital face transplant program: a look back. Plast Reconstr Surg 2012;129:81e-8e. https://doi.org/10.1097/PRS.0b013e31823621db
  14. Pomahac B. Establishing a composite tissue allotransplantation program. J Reconstr Microsurg 2012;28:3-6. https://doi.org/10.1055/s-0031-1285823
  15. Lantieri L, Hivelin M, Audard V, et al. Feasibility, reproducibility, risks and benefits of face transplantation: a prospective study of outcomes. Am J Transplant 2011;11:367-78. https://doi.org/10.1111/j.1600-6143.2010.03406.x
  16. Pomahac B, Bueno EM, Sisk GC, et al. Current principles of facial allotransplantation: the Brigham and Women's Hospital Experience. Plast Reconstr Surg 2013;131:1069-76. https://doi.org/10.1097/PRS.0b013e3182865cd3
  17. Sedaghati-nia A, Gilton A, Liger C, et al. Anaesthesia and intensive care management of face transplantation. Br J Anaesth 2013;111:600-6. https://doi.org/10.1093/bja/aet159
  18. Caterson EJ, Diaz-Siso JR, Shetye P, et al. Craniofacial principles in face transplantation. J Craniofac Surg 2012;23: 1234-8. https://doi.org/10.1097/SCS.0b013e318252d406
  19. Lohn JW, Penn JW, Norton J, et al. The course and variation of the facial artery and vein: implications for facial transplantation and facial surgery. Ann Plast Surg 2011;67:184-8. https://doi.org/10.1097/SAP.0b013e31822484ae
  20. Gordon CR, Susarla SM, Peacock ZS, et al. Le Fort-based maxillofacial transplantation: current state of the art and a refined technique using orthognathic applications. J Craniofac Surg 2012;23:81-7. https://doi.org/10.1097/SCS.0b013e318240ca77
  21. Pomahac B, Pribaz JJ, Bueno EM, et al. Novel surgical technique for full face transplantation. Plast Reconstr Surg 2012; 130:549-55. https://doi.org/10.1097/PRS.0b013e31825dc25c
  22. Siemionow M, Ozturk C. Donor operation for face transplantation. J Reconstr Microsurg 2012;28:35-42. https://doi.org/10.1055/s-0031-1272963
  23. Chandawarkar AA, Diaz-Siso JR, Bueno EM, et al. Facial appearance transfer and persistence after three-dimensional virtual face transplantation. Plast Reconstr Surg 2013;132: 957-66. https://doi.org/10.1097/PRS.0b013e3182a0143b
  24. Audolfsson T, Rodriguez-Lorenzo A, Wong C, et al. Nerve transfers for facial transplantation: a cadaveric study for motor and sensory restoration. Plast Reconstr Surg 2013;131: 1231-40. https://doi.org/10.1097/PRS.0b013e31828bd394
  25. Siemionow M, Ozturk C. An update on facial transplantation cases performed between 2005 and 2010. Plast Reconstr Surg 2011;128:707e-20e. https://doi.org/10.1097/PRS.0b013e318230c77b
  26. Shanmugarajah K, Hettiaratchy S, Clarke A, et al. Clinical outcomes of facial transplantation: a review. Int J Surg 2011; 9:600-7. https://doi.org/10.1016/j.ijsu.2011.09.005
  27. Petruzzo P, Kanitakis J, Badet L, et al. Long-term follow-up in composite tissue allotransplantation: in-depth study of five (hand and face) recipients. Am J Transplant 2011;11: 808-16. https://doi.org/10.1111/j.1600-6143.2011.03469.x
  28. Siemionow M, Gharb BB, Rampazzo A. Pathways of sensory recovery after face transplantation. Plast Reconstr Surg 2011;127:1875-89. https://doi.org/10.1097/PRS.0b013e31820e90c3
  29. Gharb BB, Rampazzo A, Altuntas SH, et al. Effectiveness of topical immunosuppressants in prevention and treatment of rejection in face allotransplantation. Transplantation 2013; 95:1197-203. https://doi.org/10.1097/TP.0b013e31828bca61
  30. Ravindra KV, Xu H, Bozulic LD, et al. The need for inducing tolerance in vascularized composite allotransplantation. Clin Dev Immunol 2012;2012:438078.
  31. Leonard DA, Cetrulo CL Jr, McGrouther DA, et al. Induction of tolerance of vascularized composite allografts. Transplantation 2013;95:403-9. https://doi.org/10.1097/TP.0b013e31826d886d
  32. Siemionow M, Madajka M, Cwykiel J. Application of cellbased therapies in facial transplantation. Ann Plast Surg 2012; 69:575-9. https://doi.org/10.1097/SAP.0b013e31824803a5
  33. Radu CA, Horn D, Kiefer J, et al. Donor-derived transplant acceptance-inducing cells in composite tissue allotransplantation. J Plast Reconstr Aesthet Surg 2012;65:1684-91. https://doi.org/10.1016/j.bjps.2012.07.003
  34. Eun SC. Composite tissue allotransplantation immunology. Arch Plast Surg 2013;40:141-53. https://doi.org/10.5999/aps.2013.40.2.141
  35. Siemionow M. Impact of reconstructive transplantation on the future of plastic and reconstructive surgery. Clin Plast Surg 2012;39:425-34. https://doi.org/10.1016/j.cps.2012.07.011
  36. Ren X, Laugel MC. The next frontier in composite tissue allotransplantation. CNS Neurosci Ther 2013;19:1-4. https://doi.org/10.1111/cns.12029
  37. Murphy BD, Zuker RM, Borschel GH. Vascularized composite allotransplantation: an update on medical and surgical progress and remaining challenges. J Plast Reconstr Aesthet Surg 2013;66:1449-55. https://doi.org/10.1016/j.bjps.2013.06.037
  38. Cornell C. Tuberculosis in hospital employees. Am J Nurs 1988;88:484-6. https://doi.org/10.2307/3426015
  39. Lantieri LA. Face transplant: learning from the past, facing the future. Proc Am Philos Soc 2011;155:23-8.
  40. Pomahac B, Diaz-Siso JR, Bueno EM. Evolution of indications for facial transplantation. J Plast Reconstr Aesthet Surg 2011;64:1410-6. https://doi.org/10.1016/j.bjps.2011.06.024

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