References
- Miller, J.D. Aspects of the ecology of Fusarium toxins in cereals. Adv. Exp. Med. Biol. 504, 19-27 (2002). https://doi.org/10.1007/978-1-4615-0629-4_3
- Miller, J.D. Mycotoxins in small grains and maize: old problems, new challenges. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 25, 219-230 (2008). https://doi.org/10.1080/02652030701744520
- Pieters, M.N., Bakker, M. Slob, W. Reduced intake of deoxynivalenol in The Netherlands: a risk assessment update. Toxicol. Lett. 153, 145-153 (2004). https://doi.org/10.1016/j.toxlet.2004.04.029
- Pestka, J.J., Islam, Z.Amuzie, C.J. Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol. Lett. 178, 83-87 (2008). https://doi.org/10.1016/j.toxlet.2008.02.005
- Fiocchi, C. Towards a 'cure' for IBD. Dig. Dis. 30, 428-433 (2012). https://doi.org/10.1159/000338148
- Prelusky, D.B., Veira, D.M., Trenholm, H.L.Foster, B.C. Metabolic fate and elimination in milk, urine and bile of deoxynivalenol following administration to lactating sheep. J. Environ. Sci. Health B. 22, 125-148 (1987). https://doi.org/10.1080/03601238709372550
- Swanson, S.P., Dahlem, A.M., Rood, H.D., Jr., Cote, L.M., Buck, W.B.Yoshizawa, T. Gas chromatographic analysis of milk for deoxynivalenol and its metabolite DOM-1. J. Assoc. Off. Anal. Chem. 69, 41-43 (1986).
- Berthiller, F., Dall'asta, C., Corradini, R., Marchelli, R., Sulyok, M., Krska, R., Adam, G.Schuhmacher, R. Occurrence of deoxynivalenol and its 3-beta-D-glucoside in wheat and maize. Food. Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 26, 507-511 (2009). https://doi.org/10.1080/02652030802555668
- Gratz, S.W., Duncan, G.Richardson, A.J. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3- glucoside and may be responsible for urinary deepoxy-deoxynivalenol. Appl. Environ. Microbiol. 79, 1821-1825 (2013). https://doi.org/10.1128/AEM.02987-12
- Nagl, V., Schwartz, H., Krska, R., Moll, W.D., Knasmuller, S., Ritzmann, M., Adam, G.Berthiller, F. Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats. Toxicol. Lett. 213, 367-373 (2012). https://doi.org/10.1016/j.toxlet.2012.07.024
- Lattanzio, V.M., Solfrizzo, M., De Girolamo, A., Chulze, S.N., Torres, A.M.Visconti, A. LC-MS/MS characterization of the urinary excretion profile of the mycotoxin deoxynivalenol in human and rat. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 879, 707-715 (2011). https://doi.org/10.1016/j.jchromb.2011.01.029
- Meky, F.A., Turner, P.C., Ashcroft, A.E., Miller, J.D., Qiao, Y.L., Roth, M.J.Wild, C.P. Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem. Toxicol. 41, 265-273 (2003). https://doi.org/10.1016/S0278-6915(02)00228-4
- Turner, P.C., Burley, V.J., Rothwell, J.A., White, K.L., Cade, J.E.Wild, C.P. Deoxynivalenol: rationale for development and application of a urinary biomarker. Food. Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 25, 864-871 (2008). https://doi.org/10.1080/02652030801895040
- Warth, B., Sulyok, M., Fruhmann, P., Berthiller, F., Schuhmacher, R., Hametner, C., Adam, G., Frohlich, J.Krska, R. Assessment of human deoxynivalenol exposure using an LCMS/ MS based biomarker method. Toxicol. Lett. 211, 85-90 (2012). https://doi.org/10.1016/j.toxlet.2012.02.023
- Turner, P.C., Burley, V.J., Rothwell, J.A., White, K.L., Cade, J.E.Wild, C.P. Dietary wheat reduction decreases the level of urinary deoxynivalenol in UK adults. J. Expo. Sci. Environ. Epidemiol. 18, 392-399 (2008). https://doi.org/10.1038/sj.jes.7500611
- Turner, P.C., Taylor, E.F., White, K.L., Cade, J.E.Wild, C.P. A comparison of 24 h urinary deoxynivalenol with recent v. average cereal consumption for UK adults. Br. J. Nutr. 102, 1276-1279 (2009). https://doi.org/10.1017/S0007114509990390
- Turner, P.C., Ji, B.T., Shu, X.O., Zheng, W., Chow, W.H., Gao, Y.T.Hardie, L.J. A biomarker survey of urinary deoxynivalenol in China: the Shanghai Women's Health Study. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 28, 1220-1223 (2011). https://doi.org/10.1080/19440049.2011.584070
- Awad, W.A., Ghareeb, K., Bohm, J.Zentek, J. Decontamination and detoxification strategies for the Fusarium mycotoxin deoxynivalenol in animal feed and the effectiveness of microbial biodegradation. Food. Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess. 27, 510-520 (2010). https://doi.org/10.1080/19440040903571747
- Schatzmayr, G., Zehner, F., Taubel, M., Schatzmayr, D., Klimitsch, A., Loibner, A.P.Binder, E.M. Microbiologicals for deactivating mycotoxins. Mol. Nutr. Food Res. 50, 543-551 (2006). https://doi.org/10.1002/mnfr.200500181
- Awad, W.A., Bohm, J., Razzazi-Fazeli, E., Ghareeb, K. Zentek, J. Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chickens. Poult. Sci. 85, 974-979 (2006). https://doi.org/10.1093/ps/85.6.974
- Awad, W.A., Bohm, J., Razzazi-Fazeli, E., Hulan, H.W. Zentek, J. Effects of deoxynivalenol on general performance and electrophysiological properties of intestinal mucosa of broiler chickens. Poult. Sci. 83, 1964-1972 (2004). https://doi.org/10.1093/ps/83.12.1964
- Berthiller, F., Krska, R., Domig, K.J., Kneifel, W., Juge, N., Schuhmacher, R.Adam, G. Hydrolytic fate of deoxynivalenol- 3-glucoside during digestion. Toxicol. Lett. 206, 264-267 (2011). https://doi.org/10.1016/j.toxlet.2011.08.006
- Hattori, M.Taylor, T.D. The human intestinal microbiome: a new frontier of human biology. DNA Res. 16, 1-12 (2009). https://doi.org/10.1093/dnares/dsn033
- Maul, R., Warth, B., Kant, J.S., Schebb, N.H., Krska, R., Koch, M.Sulyok, M. Investigation of the hepatic glucuronidation pattern of the Fusarium mycotoxin deoxynivalenol in various species. Chem. Res. Toxicol. 25, 2715-2717 (2012). https://doi.org/10.1021/tx300348x
- Uhlig, S., Ivanova, L.Faeste, C.K. Enzyme-assisted synthesis and structural characterization of the 3-, 8-, and 15-glucuronides of deoxynivalenol. J. Agric. Food Chem. 61, 2006- 2012 (2013). https://doi.org/10.1021/jf304655d
- Kim, E.J., Jeong, S.H., Cho, J.H., Ku, H.O., Pyo, H.M., Kang, H.G.Choi, K.H. Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication. J. Vet. Sci. 9, 257-266 (2008). https://doi.org/10.4142/jvs.2008.9.3.257
- Mikami, O., Kubo, M., Murata, H., Muneta, Y., Nakajima, Y., Miyazaki, S., Tanimura, N.Katsuda, K. The effects of acute exposure to deoxynivalenol on some inflammatory parameters in miniature pigs. J. Vet. Med. Sci. 73, 665-671 (2011). https://doi.org/10.1292/jvms.10-0461
- Moon, Y. Ribosomal alteration-derived signals for cytokine induction in mucosal and systemic inflammation: noncanonical pathways by ribosomal inactivation. Mediators Inflamm. 2014, 708193 (2014).
- Moon, Y., Yang, H.Lee, S.H. Modulation of early growth response gene 1 and interleukin-8 expression by ribotoxin deoxynivalenol (vomitoxin) via ERK1/2 in human epithelial intestine 407 cells. Biochem. Biophys. Res. Commun. 362, 256-262 (2007). https://doi.org/10.1016/j.bbrc.2007.07.168
- Park, S.H., Do, K.H., Choi, H.J., Kim, J., Kim, K.H., Park, J., Oh, C.G.Moon, Y. Novel regulatory action of ribosomal inactivation on epithelial Nod2-linked proinflammatory signals in two convergent ATF3-associated pathways. J. Immunol. 191, 5170-5181 (2013). https://doi.org/10.4049/jimmunol.1301145
- Dewa, Y., Kemmochi, S., Kawai, M., Saegusa, Y., Harada, T., Shimamoto, K., Mitsumori, K., Kumagai, S., Sugita-Konishi, Y.Shibutani, M. Rapid deposition of glomerular IgA in BALB/ c mice by nivalenol and its modifying effect on high IgA strain (HIGA) mice. Exp. Toxicol. Pathol. 63, 17-24 (2011). https://doi.org/10.1016/j.etp.2009.09.002
- Goyarts, T., Danicke, S., Tiemann, U.Rothkotter, H.J. Effect of the Fusarium toxin deoxynivalenol (DON) on IgA, IgM and IgG concentrations and proliferation of porcine blood lymphocytes. Toxicol. In Vitro. 20, 858-867 (2006). https://doi.org/10.1016/j.tiv.2005.12.006
- Pestka, J.J., Moorman, M.A.Warner, R.L. Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin. Food Chem. Toxicol. 27, 361-368 (1989). https://doi.org/10.1016/0278-6915(89)90141-5
- Flannery, B.M., Wu, W.Pestka, J.J. Characterization of deoxynivalenol- induced anorexia using mouse bioassay. Food Chem. Toxicol. 49, 1863-1869 (2011). https://doi.org/10.1016/j.fct.2011.05.004
- Wu, W., Flannery, B.M., Sugita-Konishi, Y., Watanabe, M., Zhang, H.Pestka, J.J. Comparison of murine anorectic responses to the 8-ketotrichothecenes 3-acetyldeoxynivalenol, 15-acetyldeoxynivalenol, fusarenon X and nivalenol. Food Chem. Toxicol. 50, 2056-2061 (2012). https://doi.org/10.1016/j.fct.2012.03.055
- Girardet, C., Bonnet, M.S., Jdir, R., Sadoud, M., Thirion, S., Tardivel, C., Roux, J., Lebrun, B., Mounien, L., Trouslard, J., Jean, A., Dallaporta, M.Troadec, J.D. Central inflammation and sickness-like behavior induced by the food contaminant deoxynivalenol: a PGE2-independent mechanism. Toxicol. Sci. 124, 179-191 (2011). https://doi.org/10.1093/toxsci/kfr219
- Prelusky, D.B. The effect of low-level deoxynivalenol on neurotransmitter levels measured in pig cerebral spinal fluid. J. Environ. Sci. Health B. 28, 731-761 (1993). https://doi.org/10.1080/03601239309372851
- Prelusky, D.B. The effect of deoxynivalenol on serotoninergic neurotransmitter levels in pig blood. J Environ Sci Health B. 29, 1203-1218 (1994). https://doi.org/10.1080/03601239409372923
- Prelusky, D.B., Rotter, B.A., Thompson, B.K.Trenholm, H.L. Effect of the appetite stimulant cyproheptadine on deoxynivalenol- induced reductions in feed consumption and weight gain in the mouse. J. Environ. Sci. Health B. 32, 429-448 (1997). https://doi.org/10.1080/03601239709373096
- Gaige, S., Bonnet, M.S., Tardivel, C., Pinton, P., Trouslard, J., Jean, A., Guzylack, L., Troadec, J.D.Dallaporta, M. c-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons. Neurotoxicology. 34, 135-149 (2013). https://doi.org/10.1016/j.neuro.2012.10.020
- Wu, W., Bates, M.A., Bursian, S.J., Flannery, B., Zhou, H.R., Link, J.E., Zhang, H.Pestka, J.J. Peptide YY3-36 and 5- hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin). Toxicol. Sci. 133, 186- 195 (2013). https://doi.org/10.1093/toxsci/kft033
- Widestrand, J., Lundh, T., Pettersson, H.Lindberg, J.E. Cytotoxicity of four trichothecenes evaluated by three colorimetric bioassays. Mycopathologia. 147, 149-155 (1999). https://doi.org/10.1023/A:1007127919901
- Shi, Y., Porter, K., Parameswaran, N., Bae, H.K.Pestka, J.J. Role of GRP78/BiP degradation and ER stress in deoxynivalenol- induced interleukin-6 upregulation in the macrophage. Toxicol. Sci. 109, 247-255 (2009). https://doi.org/10.1093/toxsci/kfp060
- Yang, H., Park, S.H., Choi, H.J., Do, K.H., Kim, J., An, T.J., Lee, S.H.Moon, Y. Mechanism-based alternative monitoring of endoplasmic reticulum stress by 8-keto-trichothecene mycotoxins using human intestinal epithelial cell line. Toxicol. Lett. 198, 317-323 (2010). https://doi.org/10.1016/j.toxlet.2010.07.008
- Diesing, A.K., Nossol, C., Danicke, S., Walk, N., Post, A., Kahlert, S., Rothkotter, H.J.Kluess, J. Vulnerability of polarised intestinal porcine epithelial cells to mycotoxin deoxynivalenol depends on the route of application. PLoS One. 6, e17472 (2011). https://doi.org/10.1371/journal.pone.0017472
- Akbari, P., Braber, S., Gremmels, H., Koelink, P.J., Verheijden, K.A., Garssen, J.Fink-Gremmels, J. Deoxynivalenol: a trigger for intestinal integrity breakdown. Faseb J. 28, 2414-2429 (2014). https://doi.org/10.1096/fj.13-238717
- Grenier, B.Applegate, T.J. Modulation of intestinal functions following mycotoxin ingestion: meta-analysis of published experiments in animals. Toxins (Basel). 5, 396-430 (2013). https://doi.org/10.3390/toxins5020396
- Huh, D., Kim, H.J., Fraser, J.P., Shea, D.E., Khan, M., Bahinski, A., Hamilton, G.A.Ingber, D.E. Microfabrication of human organs-on-chips. Nat. Protoc. 8, 2135-2157 (2013). https://doi.org/10.1038/nprot.2013.137