Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Inhalation of Carbon Black Nanoparticles Aggravates Pulmonary Inflammation in Mice

  • Saputra, Devina (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Yoon, Jin-Ha (Institute for Occupational Health, Yonsei University College of Medicine) ;
  • Park, Hyunju (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Heo, Yongju (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Yang, Hyoseon (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Lee, Eun Ji (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Lee, Sangjin (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Song, Chang-Woo (Inhalation Toxicology Center, Korea Institute of Toxicology) ;
  • Lee, Kyuhong (Inhalation Toxicology Center, Korea Institute of Toxicology)
  • Received : 2014.03.14
  • Accepted : 2014.06.15
  • Published : 2014.06.30
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Abstract

An increasing number of recent studies have focused on the impact of particulate matter on human health. As a model for atmospheric particulate inhalation, we investigated the effects of inhaled carbon black nanoparticles (CBNP) on mice with bleomycin-induced pulmonary fibrosis. The CNBPs were generated by a novel aerosolization process, and the mice were exposed to the aerosol for 4 hours. We found that CBNP inhalation exacerbated lung inflammation, as evidenced by histopathology analysis and by the expression levels of interleukin-6 protein, fibronectin, and interferon-${\gamma}$ mRNAs in lung tissues. Notably, fibronectin mRNA expression showed a statistically significant increase in expression after CBNP exposure. These data suggest that the concentration of CBNPs delivered (calculated to be $12.5{\mu}g/m^3$) can aggravate lung inflammation in mice. Our results also suggest that the inhalation of ultrafine particles like PM 2.5 is an impactful environmental risk factor for humans, particularly in susceptible populations with predisposing lung conditions.

Keywords

References

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