Journal of Digestive Cancer Research

Korean Society of Gastrointestinal Cancer Research (대한소화기암연구학회)
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A Case of Intraductal Papillary Neoplasm of the Bile Duct with 8 Years of Follow Up

담관의 관내 유두상 종양에서 발생한 간 내 담관암 1예: 8년 간의 경과관찰

  • Hye Kyung Jeon (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Dong Uk Kim (Department of Internal Medicine, Pusan National University School of Medicine)
  • 전혜경 (부산대학교 의학전문대학원 내과학교실) ;
  • 김동욱 (부산대학교 의학전문대학원 내과학교실)
  • Received : 2014.12.22
  • Accepted : 2014.12.29
  • Published : 2014.12.31
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Abstract

Intraductal papillary neoplasm of the bile duct (IPN-B) is a rare disease characterized by multicentric proliferation of adenomatous epithelium within the bile ducts. It has better prognosis because of slow disease progression and high probability of early diagnosis, but also has potential for malignant transformation. Therefore early treatment such as surgical resection has been recommended. There are few reports about nature course of IPN-B without treatment. We report a case of papillary adenoma of intrahepatic duct that transformed into intrahepatic cholangiocarcinoma with 8 years of follow up.

담관암은 예후가 불량한 암으로 전암성 병변의 병리, 임상적 특징, 예후 등의 이해가 중요할 것으로 생각된다. 관내 유두상 종양은 드문 질환으로 만성적인 담관의 염증이 동반되어 있는 환자에서 발생 위험이 증가하며 비교적 느리게 성장하고 덜 침습적인 특징이 있으나 악성 전환 가능성이 높은 질병이므로 첫 진단 시 조직학적으로 양성이라 하더라도 적극적인 치료를 고려하도록 권고하고 있다. 이에 질병의 자연경과에 대한 보고는 적어, 저자들은 치료없이 8년간 경과 관찰하여 담관암으로 진행한 담관내 유두상 종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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