Journal of Digestive Cancer Research

  • 제2권1호
  • /
  • Pages.24-27
  • /
  • 2014
  • /
  • 2950-9394(pISSN)
  • /
  • 2950-9505(eISSN)
대한소화기암연구학회 (Korean Society of Gastrointestinal Cancer Research)
권호 표지

동시에 발견된 위장관 간질 종양과 점막하 종양 형태의 MALT 림프종의 내시경 치료

Endoscopic Submucosal Dissection for Simultaneous Presence of GIST and Submucosal Tumor Type MALT-Lymphoma on the Stomach ?

  • 유인경 (고려대학교 의과대학 내과학교실) ;
  • 전훈재 (고려대학교 의과대학 내과학교실) ;
  • 진윤태 (고려대학교 의과대학 내과학교실) ;
  • 금보라 (고려대학교 의과대학 내과학교실) ;
  • 김은선 (고려대학교 의과대학 내과학교실) ;
  • 최혁순 (고려대학교 의과대학 내과학교실) ;
  • 남승주 (고려대학교 의과대학 내과학교실)
  • In Kyung Yoo (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Hoon Jai Chun (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Yoon Tae Jeen (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Bora Keum (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Eun Sun Kim (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Hyuk Soon Choi (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital) ;
  • Seung Joo Nam (Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Anam Hospital)
  • 투고 : 2014.05.15
  • 심사 : 2014.05.31
  • 발행 : 2014.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 증례에서는 우연히 한 환자에서 위장관 간질 종양과 점막하 종양 형태의 MALT 림프종을 동시에 발견하였고, 이를 내시경적 절제술로 치료한 사례이다. 현재 환자는 절제술 후 2년 동안 질병의 진행 없이 외래에서 경과 관찰 중이다. 아직 MALT 림프종과 위장관 간질종양에서 내시경적 점막하 절제술은 정립된 치료 방법이 아니지만, 본 증례처럼 성공적으로 치료될 수 있음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. 아직은 내시경적 절제술로 치료한 사례가 적지만, 향후 내시경적 절제술 후 긴 기간 동안 추적 관찰된 증례들이 모인다면 조기위암처럼 표준화된 치료법으로 시행될 수 있기를 기대한다.

A 42-year-old female was referred to our department after find out submucosal tumor type lesion on cardia at local clinics. She experienced no specific symptom. On gastroscopy, two distinct neoplasms were detected. One of which was located in the cardia anterior wall of the stomach with the size of 2.0×1.1 cm, and the other one was localized in the cardia posterior wall of the stomach and its size was 1.5×1.2 cm. We performed endoscopic submucosal dissection. Pathological evaluation revealed the diagnosis of gastrointestinal stromal tumor (GIST) at the cardia anterior wall and malignant lymphoma from the mass localized cardia posterior wall of the stomach. We would like to report these rare synchronous tumors which were successfully treated by endoscopic resection in the same patient

키워드

참고문헌

  1. Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Annals of oncology: official journal of the European Society for Nedical Oncology/ ESMO. 2008;19(12):1992-1999.
  2. Sircar K, Hewlett B, Huizinga J, Chorneyko K, Berezin I, Riddell R. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. The American journal of surgical pathology. 1999;23(4):377-389.
  3. Burnming P, Andersson J, Meis-Kindblom J, Klingenstierna H, Engstrom K, Stierner U, et al. Neoadjuvant, adjuvant and palliative treatment of gastrointestinal stromal tumours (GIST) with imatinib: a centre-based study of 17 patients. British journal of cancer. 2003;89(3) :460-464.
  4. Kaffes A, Hughes L, Hollinshead J, Katelaris P. Synchronous primary adenocarcinoma, mucosa-associated lymphoid tissue lymphoma and a stromal tumor in a Helicobacter pylori-infected stomach. Journal of gastroenterology and hepatology. 2002;17(9):1033-1036.
  5. Salar A, Ramon JM, Barranco C, Nieto M, Prats M, Serrano S, et al. Double diagnosis in cancer patients and cutaneous reaction related to gemcitabine: CASE 1. Synchronous mucosa-associated lymphoid tissue lymphoma and gastrointestinal stromal tumors of the stomach. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2005;23(28):7221-72213.
  6. Dematteo RP, Heinrich MC, El-Rifai WeM, Demetri G. Clinical management of gastrointestinal stromal tumors: before and after STI-571. Human pathology. 2002;33(5):466-77.
  7. Davila RE, Faigel DO. GI stromal tumors. Gastrointestinal endoscopy. 2003;58(1):80-88.
  8. Lee IL, Lin PY, Tung SY, Shen CH, Wei KL, Wu CS. Endoscopic submucosal dissection for the treatment of intraluminal gastric subepithelial tumors originating from the muscularis propria layer. Endoscopy. 2006;38(10): 1024-8.
  9. Sun S, Ge N, Wang C, Wang M, Lu Q. Endoscopic band ligation of small gastric stromal tumors and follow-up by endoscopic ultrasonography. Surgical endoscopy. 2007;21(4):574-578.
  10. Bai J, Wang Y, Guo H, Zhang P, Ung X, Zhao X. Endoscopic resection of small gastrointestinal stromal tumors. Digestive diseases and sciences. 2010;55(7): 1950-1954.
  11. Choi MK, Kim GH. Diagnosis and treatment of gastric MALT lymphoma. The Korean Journal of Gastroenterology. 2011;57(5):272-280.
  12. Wotherspoon M, AC. Gastric lymphoma of mucosa-associated lymphoid tissue and Helicobacter pylori. Annual review of medicine. 1998;49(1):289-299.
  13. Nobre-Leitao C, Lage P, Cravo M, Cabecadas J, Chaves P, Alberto-Santos A, et al. Treatment of gastric MALT lymphoma by Helicobacter pylori eradication: a study controlled by endoscopic ultrasonography. The American journal of gastroenterology. 1998;93(5):732-736.
  14. Min SY, Lee JH, Rhee PL A polypoid mucosa-assodated lymphoid tissue lymphoma of the stomach treated with endoscopic polypectomy. Clinical endoscopy. 2013;46(6):647-650.
  15. Youn JC, Lee YC, Youn YH, Kim JH, Yang WI, Chung JB. Two cases of low grade gastric-mucosa-associated lymphoid tissue lymphoma treated by EMR. Gastrointestinal endoscopy. 2006;64(3):456-460.