The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지
DOI QR코드

DOI QR Code

The Effect of Nutritional Management and Exercise on Serum Homocystein Level and Antioxidant Intake in Middle Aged Obese Women

영양관리와 운동이 중년 비만여성의 혈중 호모시스테인 수준과 항산화 영양소 섭취에 미치는 영향

  • Han, Jung-Soon (Dokhaksa College in Lifelong Center of Seoul National University of Education) ;
  • Kim, Ae-Jung (Dept. of Alternative Medicine, Kyonggi University)
  • 한정순 (서울교육대학교 평생교육원 독학사칼리지) ;
  • 김애정 (경기대학교 대체의학대학원)
  • Received : 2014.03.19
  • Accepted : 2014.06.13
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the association of homocysteine and antioxidant nutrients with obesity in Korean middle aged women. The study subjects included were middle-aged obese women (n=36) whose body mass index (BMI) was greater than $25kg/m^2$. A total of 36 participants were randomly divided into two groups. They were assigned to either the Nutritional Management and Exercise (NME) program or the Exercise Management (EM) program, which were both conducted for 3 months. We measured serum homocysteine, total cholesterol and HDL cholesterol levels of the participant. We also measured the dietary intakes of antioxidant nutrient, cholesterol, body weight, body mass index, blood pressure, and $VO_2$. At the end of both programs, please confirm this change. It was unclear when these measurements were shown to have decreased. The body weight and BMI of NME group were decreased compared to those of EM group. The serum total cholesterol levels of the participants in NME group were significantly decreased, in contrast to EM group. Also, serum homocysteine levels of NME group participants were decreased compared to EM group, but the difference was not statistically significant. In the NME group, there were significant differences in the change of dietary cholesterol and vitamin C intake. These results showed that participating NME program will continuously promote the healthy status of the middle aged obese women, compared to participating only in the EM program.

Keywords

References

  1. Boushey CJ, Shirley RD, Beresford AA. 1995. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intake. JAMA 274:1049-1057 https://doi.org/10.1001/jama.1995.03530130055028
  2. Christensen JR, Faber A, Ekner D, Overgaard K, Holtermann A, Sogaard K. 2011. Diet, physical exercise and cognitive behavioral training as a combined workplace based intervention to reduce body weight and increase physical capacity in health care workers - a randomized controlled trial. BMC Public Health 11:671-678 https://doi.org/10.1186/1471-2458-11-671
  3. Hahn D, Payne W, Lucas E. 2013. Focus on Health. 11th ed. New York: McGrow Hill Humanities
  4. Jacobsen DW, Gatautis VJ, Green R, Robinson K, Savon SR, Secic M, Ji J, Otto JM, Taylor LM Jr. 2009. Total plasma homocysteine: the mediator/marker controversy continues. Clin Chem 55:1742-1743 https://doi.org/10.1373/clinchem.2009.128744
  5. Julve J, Escola-Gil JC, Rodriguez-Millan E, Martin-Campos JM, Jauhiainen M, Quesada H, Renteria-Obregon IM, Osada J, Sanchez-Quesada JL, Blanco-Vaca F. 2013. Methionine-induced hyperhomocysteinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo macrophagespecific reverse cholesterol transport. Mol Nutr Food Res 57:1814-1824
  6. Kim MS, Ahn HS. 2003. Dietary intakes and serum component in middle aged abdominal obese women. Korean J Obes 12:124-136
  7. Korea Center for Disease Control and Prevention. 2010. Korea Health Statistics 2009 Quality control and analysis support on nutrition survey of KNHANES IV. Seoul: Korea Center for Disease Control and Prevention
  8. Korea Institute for Health and Social Affairs. 2004. Korean Women's Health Statistics. Seoul: Korea Institute for Health and Social Affairs
  9. Lee JH, Jang YS, Park HY, Kim OY, Ryu HJ, Chae JS. 1999. Beneficial effect of weight reduction in overweight middle aged men. The J of Obesity 8:154-163
  10. Lee JK, Yu BY, Choi DY. 2000. Relations between obesity indices and smoking, alcohol, lipid, blood glucose and blood pressure. The Kon-Kuk J of Medical Sci 10:111-118
  11. Lemieux I, Pascot A, Prud'homme D, Almeras N, Bogaty P, Nadeau A. 1982. Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity. Arterioscler Thromb Vasc Biol 21:961-967
  12. Mehlig K, Leander K, de Faire U, Nyberg F, Berg C, Rosengren A, Bjorck L, Zetterberg H, Blennow K, Tongnon G, Torin K, Strdhagen E, Liesser L, Thelle D. 2013. The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism. Heart 99:1761-1765 https://doi.org/10.1136/heartjnl-2013-304460
  13. Mehmetoglu I, Yerlikaya FH, Kurban S, Polat H. 2012 Plasma ${\omega}$-3 fatty acid levels negatively and ${\omega}$-6 fatty acid levels positively associated with other cardiovascular risk factors including homocysteine in severe obese subjects. Asia Pac J Clin Nutr 21:519-25
  14. Oh KW, Lee WY, Ahn YB, Song KH, Yoo SJ, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK 1999. Homocysteine, folate, and methylenetetrahydrofolate reductase polymorphism in Korean normal subjects. Korean J Med 57:1030-1033
  15. Otsuji S, Shibata H, Umeda M. 1982. Turbidimetric immunoassay of serum C-reactive protein. Clin Chem 28:2121-2124
  16. Reeves WG. 1983 Insulin antibody determination : theoretical and practical considerations. Diabetologia 24:399-403
  17. Sengwayo D, Moraba M, Motaung S. 2013. Association of homocysteinaemia with hyperglycemia, dyslipidaemia, hypertension and obesity. Cardiovasc J Afr 24:265-269 https://doi.org/10.5830/CVJA-2013-059
  18. Simonetta F, Paul F, Jacques P, Wilson W, Irwin H, Rosenberg, Jacob S. 2001. Low circulating vitamin $B_6$ is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 103:2788-2791 https://doi.org/10.1161/01.CIR.103.23.2788
  19. Sonia SA, Daniel GH. 2003. Emerging risk factors for atherosclerotic vascular disease. JAMA 290:932-940 https://doi.org/10.1001/jama.290.7.932
  20. Ueland PM. 1995. Homocysteine species as component of plasma redox thio status. Clini Chem 41:340-342
  21. Yi KN, Kwon OH. 2000. Clinical Pathology File. 3rd ed. pp. 14-62. Seoul: Medrang, Inforang