한국방사선학회논문지 (Journal of the Korean Society of Radiology)

  • 제8권4호
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  • Pages.163-170
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  • 2014
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  • 1976-0620(pISSN)
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  • 2384-0633(eISSN)
한국방사선학회 (The Korean Society of Radiology)
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뇌 자기공명영상에서 대뇌 피질 두께 분석법을 이용한 파킨슨병의 경도인지장애 신경심리검사와 신경해부학적 상관관계

Correlation of the Neuropsychological Screening Battery (NSB) and Neuroanatomy for the Parkinson's Disease with Mild Cognitive Impairment by Using the Analysis of Cerebral Cortex Thickness in the Brain MRI

  • 이현용 (인제대학교 부산백병원 영상의학과) ;
  • 박형후 (봉생병원 영상의학과) ;
  • 이재승 (동의대학교 방사선학과) ;
  • 임인철 (동의대학교 방사선학과)
  • Lee, Hyeonyong (Department of Radiology, Inje Univiersity Busan Paik Hospital) ;
  • Park, Hyonghu (Department of Radiology, Bongseng Memorial Hospital) ;
  • Lee, Jaeseung (Department of Radiological Science, Dongeui University) ;
  • Im, Inchul (Department of Radiological Science, Dongeui University)
  • 투고 : 2014.04.30
  • 심사 : 2014.06.25
  • 발행 : 2014.06.30
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초록

본 연구는 경도인지장애가 동반된 환자를 대상으로 뇌 자기공명영상에서 인지 영역에 대한 대뇌 피질 두께를 측정하고 신경심리검사 결과와 비교하여 신경해부학적 상관관계를 규명하고자 하였다. 이를 위하여 파킨슨병으로 최초 진단 받고 신경심리검사를 시행한 78명(경도인지장애군: 39명; 비인지장애군: 39명)과 정상인 그룹 32명을 선정하였다. 신경심리검사에서 경도인지장애군과 비인지장애군의 상관관계와 신경심리검사와 뇌 자기공명영상에서 대뇌 피질 두께의 상관관계는 독립표본 T 검증 또는 피어슨 상관분석을 실시하였으며 수집된 자료의 유의 수준은 p<0.05에서 검증하였다. 결론적으로 경도인지장애를 동반한 파킨슨병 환자는 뇌 자기공명영상에서 양측 쐐기압소엽과 우하측두엽의 대뇌 피질 두께가 통계적으로 유의하게 감소하였으며 인지 기능 평가를 위한 신경심리검사에서 시공간 기능, 언어 및 시각 기억력 기능이 저하되었다. 특히 언어 및 시각 기억력 영역에 대한 신경심리검사와 신경해부학적으로 좌측 쐐기앞소엽에서 상관관계가 있었다.

This study is to investigate neuro-anatomical correlation between neuropsychological results and cerebral cortex thickness of cognitive ability in the brain MRI targeting the patients with mild cognitive impairment. It was that 78 people who were diagnosed as first Parkinson's disease followed by neuropsychological screening battery(Parkinson's disease with mild cognitive impairment: 39 people; Parkinson's disease with normal cognition: 39 people) and 32 people of normal group were selected. Correlation between mild cognitive impairment and normal cognitive impairment and correlation between neuropsychological screening battery and cerebral cortex thickness in the brain MRI were performed by independent sample t-test or Pearson correlation coefficient and then level of significance of collected data was verified in p<0.05. As a result, cerebral cortex thickness of the Parkinson's disease with mild cognitive impairment in both side precuneas and right inferiortemporal lobe had statistically significant decrease. In addition, function of visuospatial ability, verbal and visual memory was reduced in neuropsychological screening battery for cognitive assessment. Especially, there was correlation between neuropsychological screening battery of verbal and visual memory anatomical left precuneus.

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참고문헌

  1. L. M. de Lau, M. M. Breteler, "Epidemiology of Parkinson's disease", Lancet. Neurology, Vol. 5, No. 6, pp. 525-535, 2006. https://doi.org/10.1016/S1474-4422(06)70471-9
  2. A. Schrag, Y. Ben-Shlomo, N. P. Quinn, "Cross sectional prevalence survey of idiopathic Parkinson's disease and Parkinsonism in London", BMJ, Vol.321, No.7252, pp. 21-22, 2000. https://doi.org/10.1136/bmj.321.7252.21
  3. Health Insurance Review & Assessment Service, "Ministry for health, welfare and family affairs", 2010 (http://www.mw.go.kr).
  4. A. W. Willis, M. Schootman, N. Kung, B. A. Evanoff, J. S. Perlmutter, B. A. Racette, "Predictors of survival in patients with Parkinson disease", Arch. Neurol., Vol. 69, No. 5, pp. 601-607, 2012. https://doi.org/10.1001/archneurol.2011.2370
  5. K. R. Chaudhuri, D. G. Healy, A. H. Schapira, "Non-motor symptoms of Parkinson's disease: diagnosis and management", Lancet. Neurol., Vol. 5, No. 2, pp. 235-245, 2006. https://doi.org/10.1016/S1474-4422(06)70373-8
  6. A. Sauerbier, K. Ray Chaudhuri, "Non-motor symptoms: the core of multi-morbid Parkinson's disease", Br. J. Hosp. Med., Vol. 75, No. 1, pp. 18-24, 2014. https://doi.org/10.12968/hmed.2014.75.1.18
  7. M. W. Bondi, G. E. Smith, "Mild cognitive impairment: a concept and diagnostic entity in need of input from neuropsychology", J. Int. Neuropsychol. Soc., Vol. 20, No. 2, pp. 129-134, 2014. https://doi.org/10.1017/S1355617714000010
  8. K. Matsuura, M. Maeda, K. Yata, Y. Ichiba, T. Yamaguchi, K. Kanamaru, H. Tomimoto, "Neuromelanin magnetic resonance imaging in Parkinson's disease and multiple system atrophy", Eur. Neurol., Vol. 70, No. 1-2, pp. 70-77, 2013. https://doi.org/10.1159/000350291
  9. H. J. Ahn, J. Chin, A. Park, B. H. Lee, S. W. Seo, D. L. Na, "Seoul Neuropsychological Screening Battery-dementia version (SNSB-D): a useful tool for assessing and monitoring cognitive impairments in dementia patients", J. Korean Med. Sci., Vol. 25, No. 7, pp. 1071-1076, 2010. https://doi.org/10.3346/jkms.2010.25.7.1071
  10. A. Gmitrowicz, A. Kucharska, "Developmental disorders in the fourth edition of the American classification: diagnostic and statistical manual of mental disorders (DSM IV - optional book)", Psychiatr. Pol., Vol. 28, No. 5, pp. 509-521, 1994.
  11. D. A. Regier, W. E. Narrow, M. B. First, T. Marshall, "The APA classification of mental disorders: future perspectives", Psychopatholog, yVol. 35, No. 2-3, pp. 166-170, 2002. https://doi.org/10.1159/000065139
  12. C. G. Goets, W. Poewe, O. Rascol, C. Sampaio, G. T. Stebbins, C. Counsell, N. Giladi, R. G. Holloway, C. G. Moore, G. K. Wenning, M. D. Yahr, L. Seidl; Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease, "The Unified Parkinson's Disease Rating Scale (UPDRS): Status and recommendations", Mov. Disord., Vol. 18, No. 7, pp. 738-750, 2003. https://doi.org/10.1002/mds.10473
  13. M. J. Falvo, B. K. Schilling, G. M. Earhart, "Parkinson's disease and resistive exercise: rationale, review, and recommendations", Mov. Disord., Vol. 23, No. 1, pp. 1-11, 2008. https://doi.org/10.1002/mds.21690
  14. S. A. Choi, J. H. Kim, M. S. Lee, "Status of Korea patients with Parkinson's disease before diagnosis", J. Korean Neurol. Assoc., Vol. 18, No. 6, pp. 687-693, 2000.
  15. Korean Neurological Association, "Neurology" 2nd Edition, Panmun Education, p. 452, 2012.
  16. A. J. Yarnall, L. Rochester, D. J. Burn, "Mild cognitive impairment in Parkinson's disease", Age. Ageing, Vol. 42, No. 5, pp. 567-576, 2013. https://doi.org/10.1093/ageing/aft085
  17. H. Hildebrandt, F. Fink, A. Kastrup, M. Haupts, P. Eling, "Cognitive profiles of patients with mild cognitive impairment or dementia in Alzheimer's or Parkinson's disease", Dement. Geriatr. Cogn. Dis. Extra., Vol. 3, No. 1, pp. 102-112, 2013. https://doi.org/10.1159/000348350
  18. S. H. Choi, "Cognitive Function and MRI Parameters in Mild Cognitive Impairment Subjects", University of Ulsan graduate school, 2007.
  19. J. E. Lee, "Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease", Yonsei University graduate school, 2010.
  20. P. C. Fletcher, C. D. Frith, S. C. Baker, T. Shallice, R. S. Frackowiak, R. J. Dolan, "The mind's eye-precuneus activation in memory-related imagery", Neuroimage, Vol. 2, No. 3, pp. 195-200, 1995. https://doi.org/10.1006/nimg.1995.1025
  21. T. W. Kjaer, M. Nowak, H. C. Lou, "Reflective self-awareness and conscious states: PET evidence for a common midline parietofrontal core", Neuroimage, Vol. 17, No. 2, pp. 1080-1086, 2002. https://doi.org/10.1006/nimg.2002.1230
  22. H. C. Lou, B. Luber, M. Crupain, et. al., "Parietal cortex and representation of the mental Self", Proc. Natl. Acad. Sci. USA., Vol. 101, No. 17, pp. 6827-6832, 2004. https://doi.org/10.1073/pnas.0400049101