대한본초학회지 (The Korea Journal of Herbology)

  • 제29권3호
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  • Pages.11-17
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  • 2014
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
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마치현(馬齒莧)의 급성 췌장염 보호 효과

Protective effects of Portulaca oleracea against cerulein-induced acute pancreatitis

  • 곽태신 (원광대학교 한의과대학 본초학교실) ;
  • 김동구 (원광대학교 한의과대학 본초학교실) ;
  • 김주영 (계명대학교 의과대학 예방의학과) ;
  • 배기상 (원광대학교 한방체액조절연구센터) ;
  • 최선복 (원광대학교 한의학전문대학원 BK21 plus 사업팀) ;
  • 조일주 (원광대학교 한의과대학 본초학교실) ;
  • 신준연 (원광대학교 한의과대학 본초학교실) ;
  • 이성곤 (원광대학교 한의과대학 본초학교실) ;
  • 김명진 (원광대학교 한의과대학 본초학교실) ;
  • 김민준 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실) ;
  • 박성주 (원광대학교 한의과대학 본초학교실)
  • Gwak, Tae-Sin (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Dong-Goo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Ju-Young (Dept. of Preventive Medicine, School of Medicine, Keimyung University) ;
  • Bae, Gi-Sang (Hanbang Body-fluid Research Center, Wonkwang University) ;
  • Choi, Sun-Bok (BK21 plus team, Professional graduate school of Oriental medicine, Wonkwang University) ;
  • Jo, Il-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Joon-Yeon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Sung-Kon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Myoung-Jin (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Min-Jun (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
  • Park, Sung-Joo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
  • 투고 : 2014.04.25
  • 심사 : 2014.05.14
  • 발행 : 2014.05.30
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초록

Objective : Portulaca oleracea (PO) has been used as an important traditional medicine for inflammatory and bacterial diseases in East Asia. However, the protective effects of PO on acute pancreatitis (AP) is not well-known. Therefore, this study was performed to identify the anti-inflammatory and prophylactic effects of PO on cerulein-induced AP. Methods : AP was induced in mice via intraperitoneal injection of supramaximal concentrations of the stable cholecystokinin analogue cerulein ($50{\mu}g/kg$) given every hour for 6 times. Water extracts of PO (100, 300, or 500 mg/kg) was administrated intra-peritoneally 1 h prior to the first injection of cerulein. The mice were killed at 6 h after the final cerulein injection. Pancreas and lung were rapidly removed for morphologic and histochemical examination, myeloperoxidase (MPO) assay. Blood samples were taken to determine serum amylase and lipase activities. Results : Administration of PO significantly inhibited pancreatic weight/body weight ratio, pancreas and lung histological injury. And MPO activity which indicates neutrophil infiltration was inhibited by PO extracts on cerulein-induced pancreatitis. In addition, PO administration inhibited digestive enzymes such as serum amylase and lipase activity on cerulein-induced pancreatitis. Conclusion : Our results could suggest that pre-treatment of PO reduces the severity of cerulein-induced AP, thereby, PO could be used as a protective agent against AP. Also, this study could give a clinical basis that PO could be a drug or agent to prevent AP.

키워드

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