Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Mammalian RNA Granules

  • Jayabalan, Aravinth Kumar (Department of Cellular and Molecular Medicine, College of Medicine, Chosun University) ;
  • Ohn, Takbum (Department of Cellular and Molecular Medicine, College of Medicine, Chosun University)
  • Received : 2014.02.20
  • Accepted : 2014.03.13
  • Published : 2014.03.31
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Abstract

RNA granules such as Stress Granules (SG) and P-Bodies (PB) are aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes induced by a wide range of stresses. Over the past decade, extensive studies described key components of RNA granules, their molecular interactions and signaling pathways require for their assembly and disassembly. However, researches defining their exact roles under stress conditions have not been performed so far, although several studies suggested their roles in neurodegenerative diseases recently. In this review, we provide an introduction about their basic properties, key components, and the dynamic nature for their assembly.

Keywords

References

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