DOI QR코드

DOI QR Code

Antibiotics resistance of Helicobacter pylori and treatment modalities in children with H. pylori infection

  • Seo, Ji-Hyun (Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science) ;
  • Woo, Hyang-Ok (Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science) ;
  • Youn, Hee-Shang (Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science) ;
  • Rhee, Kwang-Ho (Department of Microbiology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Science)
  • 투고 : 2013.11.15
  • 심사 : 2014.01.24
  • 발행 : 2014.02.15

초록

Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H. pylori strains be eradicated. Antibiotic drug resistance to H. pylori, which has been reported to vary widely between geographic regions, is mainly associated with treatment failure in these patients. It is therefore imperative that the antibiotic resistance rates of H. pylori in children and adolescents be meticulously monitored across countries and throughout geographic regions. This paper particularly focuses on the antibiotic drug resistance of H. pylori and the thearpy of pediatric H. pylori infection cases.

키워드

참고문헌

  1. Cullen DJ, Collins BJ, Christiansen KJ, Epis J, Warren JR, Surveyor I, et al. When is Helicobacter pylori infection acquired? Gut 1993; 34:1681-2. https://doi.org/10.1136/gut.34.12.1681
  2. Parsonnet J. The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther 1995;9 Suppl 2:45-51.
  3. Megraud F. H. pylori antibiotic resistance: prevalence, importance, and advances in testing. Gut 2004;53:1374-84. https://doi.org/10.1136/gut.2003.022111
  4. You WC, Brown LM, Zhang L, Li JY, Jin ML, Chang YS, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst 2006;98:974-83. https://doi.org/10.1093/jnci/djj264
  5. Zhou LY, Lin SR, Ding SG, Huang XB, Zhang L, Meng LM, et al. The changing trends of the incidence of gastric cancer after Helicobacter pylori eradication in Shandong area. Chin J Dig Dis 2005;6:114-5. https://doi.org/10.1111/j.1443-9573.2005.00204.x
  6. Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA 2004;291:187-94. https://doi.org/10.1001/jama.291.2.187
  7. Bazzoli F, Pozzato P, Rokkas T. Helicobacter pylori: the challenge in therapy. Helicobacter 2002;7 Suppl 1:43-9. https://doi.org/10.1046/j.1523-5378.7.s1.7.x
  8. Bytzer P, O'Morain C. Treatment of Helicobacter pylori. Helicobacter 2005;10 Suppl 1:40-6. https://doi.org/10.1111/j.1523-5378.2005.00333.x
  9. Kim N, Kim JJ, Choe YH, Kim HS, Kim JI, Chung IS, et al. iagnosis and treatment guidelines for Helicobacter pylori infection in Korea. Korean J Gastroenterol 2009;54:269-78. https://doi.org/10.4166/kjg.2009.54.5.269
  10. Wolle K, Malfertheiner P. Treatment of Helicobacter pylori. Best Pract Res Clin Gastroenterol 2007;21:315-24. https://doi.org/10.1016/j.bpg.2006.11.001
  11. Glupczynski Y, Megraud F, Lopez-Brea M, Andersen LP. European multicentre survey of in vitro antimicrobial resistance in Helicobacter pylori. Eur J Clin Microbiol Infect Dis 2001;20:820-3. https://doi.org/10.1007/s100960100611
  12. Eun CS, Han DS, Park JY, Jeon YC, Hahm JS, Kim KS, et al. Changing pattern of antimicrobial resistance of Helicobacter pylori in Korean patients with peptic ulcer diseases. J Gastroenterol 2003;38:436-41. https://doi.org/10.1007/s00535-002-1079-2
  13. Koletzko S, Jones NL, Goodman KJ, Gold B, Rowland M, Cadranel S, et al. Evidence-based guidelines from ESPGHAN and NASPGHAN for Helicobacter pylori infection in children. J Pediatr Gastroenterol Nutr 2011;53:230-43.
  14. Sabbi T, De Angelis P, Dall'Oglio L. Helicobacter pylori infection in children: management and pharmacotherapy. Expert Opin Pharmacother 2008;9:577-85. https://doi.org/10.1517/14656566.9.4.577
  15. Ohkusa T, Miwa H, Endo S, Okayasu I, Sato N. Helicobacter pylori is a fragile bacteria when stored at low and ultra-low temperatures. J Gastroenterol Hepatol 2004;19:200-4. https://doi.org/10.1111/j.1440-1746.2004.03266.x
  16. Meyer JM, Silliman NP, Wang W, Siepman NY, Sugg JE, Morris D, et al. Risk factors for Helicobacter pylori resistance in the United States: the surveillance of H. pylori antimicrobial resistance partnership (SHARP) study, 1993-1999. Ann Intern Med 2002;136:13-24. https://doi.org/10.7326/0003-4819-136-1-200201010-00008
  17. Boyanova L, Nikolov R, Lazarova E, Gergova G, Katsarov N, Kamburov V, et al. Antibacterial resistance in Helicobacter pylori strains isolated from Bulgarian children and adult patients over 9 years. J Med Microbiol 2006;55(Pt 1):65-8. https://doi.org/10.1099/jmm.0.46208-0
  18. Rafeey M, Ghotaslou R, Nikvash S, Hafez AA. Primary resistance in Helicobacter pylori isolated in children from Iran. J Infect Chemother 2007;13:291-5. https://doi.org/10.1007/s10156-007-0543-6
  19. Nguyen TV, Bengtsson C, Yin L, Nguyen GK, Hoang TT, Phung DC, et al. Eradication of Helicobacter pylori in children in Vietnam in relation to antibiotic resistance. Helicobacter 2012;17:319-25. https://doi.org/10.1111/j.1523-5378.2012.00950.x
  20. Zevit N, Levy I, Shmuely H, Samra Z, Yahav J. Antibiotic resistance of Helicobacter pylori in Israeli children. Scand J Gastroenterol 2010;45:550-5. https://doi.org/10.3109/00365521003663688
  21. Oleastro M, Cabral J, Ramalho PM, Lemos PS, Paixao E, Benoliel J, et al. Primary antibiotic resistance of Helicobacter pylori strains isolated from Portuguese children: a prospective multicentre study over a 10 year period. J Antimicrob Chemother 2011;66:2308-11. https://doi.org/10.1093/jac/dkr293
  22. Seo JH, Jun JS, Yeom JS, Park JS, Youn HS, Ko GH, et al. Changing pattern of antibiotic resistance of Helicobacter pylori in children during 20 years in Jinju, South Korea. Pediatr Int 2013;55:332-6. https://doi.org/10.1111/ped.12048
  23. Vecsei A, Kipet A, Innerhofer A, Graf U, Binder C, Gizci H, et al. Time trends of Helicobacter pylori resistance to antibiotics in children living in Vienna, Austria. Helicobacter 2010;15:214-20. https://doi.org/10.1111/j.1523-5378.2010.00753.x
  24. Kim YM, Lee YJ, Oh SH, Sung H, Kim MN, Kim KM. Antimicrobial resistance of Helicobacter pylori Isolated from Korean Children. Korean J Pediatr Gastroenterol Nutr 2011;14:45-51. https://doi.org/10.5223/kjpgn.2011.14.1.45
  25. Kato S, Fujimura S. Primary antimicrobial resistance of Helicobacter pylori in children during the past 9 years. Pediatr Int 2010;52:187-90. https://doi.org/10.1111/j.1442-200X.2009.02915.x
  26. Ogata SK, Godoy AP, da Silva Patricio FR, Kawakami E. High Helicobacter pylori resistance to metronidazole and clarithromycin in Brazilian children and adolescents. J Pediatr Gastroenterol Nutr 2013;56:645-8. https://doi.org/10.1097/MPG.0b013e31828b3669
  27. Liu G, Xu X, He L, Ding Z, Gu Y, Zhang J, et al. Primary antibiotic resistance of Helicobacter pylori isolated from Beijing children. Helicobacter 2011;16:356-62. https://doi.org/10.1111/j.1523-5378.2011.00856.x
  28. Graham DY, Shiotani A. New concepts of resistance in the treatment of Helicobacter pylori infections. Nat Clin Pract Gastroenterol Hepatol 2008;5:321-31. https://doi.org/10.1038/ncpgasthep1138
  29. Koletzko S, Richy F, Bontems P, Crone J, Kalach N, Monteiro ML, et al. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 2006;55:1711-6. https://doi.org/10.1136/gut.2006.091272
  30. Versalovic J, Osato MS, Spakovsky K, Dore MP, Reddy R, Stone GG, et al. Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance. J Antimicrob Chemother 1997;40:283-6. https://doi.org/10.1093/jac/40.2.283
  31. Ko JS, Yang HR, Seo JK. Detection of 23S rRNA mutation associated with clarithromycin resistance in children with Helicobacter pylori infection. Korean J Pediatr Gastroenterol Nutr 2004;7:137-42.
  32. Kato S, Fujimura S, Udagawa H, Shimizu T, Maisawa S, Ozawa K, et al. Antibiotic resistance of Helicobacter pylori strains in Japanese children. J Clin Microbiol 2002;40:649-53. https://doi.org/10.1128/JCM.40.2.649-653.2002
  33. Rhee HS, Kim HS, Jang JJ, Seo JK. Endoscopic and pathologic analysis of pediatric Helicobacter pylori gastritis. Korean J Gastroenterol 2000;36:10-9.
  34. Gottrand F, Cullu F, Turck D, Vincent P, Michaud L, Husson MO, et al. Normal gastric histology in Helicobacter pylori-infected children. J Pediatr Gastroenterol Nutr 1997;25:74-8. https://doi.org/10.1097/00005176-199707000-00012
  35. Choe YH. Helicobacter pylori Infection in children: recommendations for diagnosis and treatment. Korean J Pediatr 2004;47:235-9.
  36. Bae SH, Koh JS, Seo JK. Therapeutic efficacy of dual therapy and triple therapy for Helicobacter pylori Infection in children. J Korean Pediatr Soc 1998;41:323-30.
  37. Choi IK, Lee SY, Chung KS. Effect of one- or two-week triple therapy with omeprazole, amoxicillin, and clarithromycin on eradication of Helicobacter pylori infection in children. Korean J Pediatr Gastroenterol Nutr 2002;5:19-25.
  38. Choi J, Jang JY, Kim JS, Park HY, Choe YH, Kim KM. Efficacy of two triple eradication regimens in children with Helicobacter pylori infection. J Korean Med Sci 2006;21:1037-40. https://doi.org/10.3346/jkms.2006.21.6.1037
  39. Hong J, Yang HR. Efficacy of proton pump inhibitor-based triple therapy and bismuth-based quadruple therapy for Helicobacter pylori eradication in Korean children. Pediatr Gastroenterol Hepatol Nutr 2012;15:237-42. https://doi.org/10.5223/pghn.2012.15.4.237
  40. Nguyen TV, Bengtsson C, Nguyen GK, Hoang TT, Phung DC, Sorberg M, et al. Evaluation of two triple-therapy regimens with metronidazole or clarithromycin for the eradication of H. pylori infection in Vietnamese children: a randomized, double-blind clinical trial. Helicobacter 2008;13:550-6. https://doi.org/10.1111/j.1523-5378.2008.00628.x
  41. Schwarzer A, Urruzuno P, Iwanczak B, Martinez-Gomez MZ, Kalach N, Roma-Giannikou E, et al. New effective treatment regimen for children infected with a double-resistant Helicobacter pylori strain. J Pediatr Gastroenterol Nutr 2011;52:424-8. https://doi.org/10.1097/MPG.0b013e3181fc8c58
  42. Iwanczak F, Iwanczak B. Treatment of Helicobacter pylori infection in the aspect of increasing antibiotic resistance. Adv Clin Exp Med 2012;21:671-80.
  43. Gotteland M, Brunser O, Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori? Aliment Pharmacol Ther 2006;23:1077-86. https://doi.org/10.1111/j.1365-2036.2006.02868.x

피인용 문헌

  1. Helicobacter pyloricolonization of the oral cavity: A milestone discovery vol.22, pp.2, 2014, https://doi.org/10.3748/wjg.v22.i2.641
  2. Increasing metronidazole and rifampicin resistance of Helicobacter pylori isolates obtained from children and adolescents between 2002 and 2015 in southwest Germany vol.22, pp.1, 2014, https://doi.org/10.1111/hel.12327
  3. Eradication Therapy for PediatricHelicobacter pyloriInfection vol.17, pp.1, 2014, https://doi.org/10.7704/kjhugr.2017.17.1.16